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Regulation of Aromatase in Normal and Malignant Breast Tissues: The Role of the Immune System

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Hormonal Carcinogenesis III

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Abstract

The crucial role that the aromatase enzyme complex has in regulating the synthesis of estrogens (E) in breast tumors has stimulated research to identify factors that regulate its activity. Es are the main hormones that support the growth of breast tumors and a number of potent aromatase inhibitors are currently being evaluated in clinical trials (1–3). Some years ago, it was discovered that concentrations of estrone and estradiol were much higher in normal and malignant breast tissues than in blood (4–6). Surprisingly, while blood E concentrations decrease at the menopause, breast tissue E concentrations are similar in pre- and postmenopausal women (7).

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Authors
  1. A. Singh
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  2. A. Purohit
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  3. M. W. Ghilchik
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  4. M. J. Reed
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Editor information

Editors and Affiliations

  1. Division of Etiology & Prevention of Hormonal Cancers Kansas Cancer Intitute, University of Kansas Medical Center, Kansas City, Kansas, 66160, USA

    Jonathan J. Li Ph.D. (Professor of Pharmacology, Toxicology, and Therapeutics Director) & Sara Antonia Li Ph.D. (Associate Professor of Pharmacology, Toxicology, and Therapeutics) (Professor of Pharmacology, Toxicology, and Therapeutics Director) &  (Associate Professor of Pharmacology, Toxicology, and Therapeutics)

  2. Division of Public Health Sciences Fred Hutchinson Cancer Research Center, University of Washington, Seattle, Washington, 98101, USA

    Janet R. Daling Ph.D.

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© 2001 Springer-Verlag New York, Inc.

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Singh, A., Purohit, A., Ghilchik, M.W., Reed, M.J. (2001). Regulation of Aromatase in Normal and Malignant Breast Tissues: The Role of the Immune System. In: Li, J.J., Li, S.A., Daling, J.R. (eds) Hormonal Carcinogenesis III. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2092-3_27

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  • DOI: https://doi.org/10.1007/978-1-4612-2092-3_27

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7411-7

  • Online ISBN: 978-1-4612-2092-3

  • eBook Packages: Springer Book Archive

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