Abstract
Heterogeneity in the performance of persons affected with schizophrenia or schizotypy psychopathology on laboratory tasks has long been recognized for the challenges it poses for experimental psychopathology, genetic, and other investigations. Traditional techniques such as factor analysis, discriminant function analysis, and cluster analysis have all been deemed inadequate for resolving heterogeneity due to one or another statistical shortcoming or limitation. A group of experimental subjects was initially identified as schizotypic using the well-known Perceptual Aberration Scale. We present a Bayesian approach, computationally implemented using a Gibbs sampling strategy, that enables one to effectively parse this experimental group in a manner that reduces heterogeneity and allows for the separation of what are termed true schizotypes and false-positives. This approach is complemented by maximum likelihood estimation, based on the expectation-maximization (EM) algorithm. The validity of our parsing strategy is supported by reference to other laboratory indexes of relevance to schizophrenia and schizotypy that were not included in the initial analyses.
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References
Bleuler, E. (1911/1950). Dementia praecox or the group of schizophrenias. (J. Zinkin, Trans.). New York: International Universities Press.
Chapman, LJ., and Chapman, JP. (1977). Selection of subjects in studies of schizophrenic cognition,Journal of Abnormal Psychology86, 10–15.
Chapman, LJ., and Chapman, JP. (1985). Psychosis proneness. In M. Alpert (Ed.), Controversies in schizophrenia: Changes and constancies (pp. 157–172 ). New York: Guilford Press. indexChapman, L.J.
Chapman, L.J., and Chapman, J.P. (1989). Strategies for resolving the het-erogeneity of schizophrenics and their relatives using cognitive measures,Journal of Abnormal Psychology98, 357 – 366.
Chapman, J.P., Chapman, L.J., and Kwapil, T.R. (1995). Scales for the measurement of schizotypy. In A. Raine, T. Lencz, & S. Mednick, (Eds.), Schizotypal personality (pp. 79 – 106 ). New York: Cambridge University Press.
Chapman, L.J., Chapman, J.P., and Raulin, M.L. (1978). Body-image aberration in schizophrenia,Journal of Abnormal Psychology87, 399 – 407.
Cornblatt, B.A., and Keilp, J.G. (1994). Impaired attention, genetics, and the pathophysiology of schizophrenia,Schizophrenia Bulletin20, 31 – 46.
Dempster, AP., Laird, NM., and Rubin, DB. (1997). Maximum likelihood from incomplete data via the EM algorithm (with discussion).Journal of the Royal Statistical SocietyB 39, 1–38.
Gelman, A. and Rubin, D. (1992). Inference from iterative simulation using multiple sequences,Statistical Science7, 457 – 511.
Geman, S. and Geman, D. (1984). Stochastic relaxation, Gibbs distributions, and the Bayesian restoration of images,IEEE Transactions on Pattern Analysis and Machine Intelligence6, 721 – 741.
Golden, R. and Meehl, P. (1980). Detection of biological sex: an empirical test of cluster methods,Multivariate Behavioral Research15, 475 – 496.
Harris, ME . (1988). Wisconsin Card Sorting Test: computer version, research edition. Odessa, FL: Psychological Assessment Resources, Inc.
Heaton, RK . (1981). Wisconsin Card Sorting Test Manual. Odessa, FL: Psychological Assessment Resources, Inc.
Kraepelin, E. (1919/1971). Dementia praecox and paraphrenia (R.M. Barclay, Trans: G.M. Robertson, Ed.). Huntington, NY: Krieger. (Original work published 1909–1913; original translation of selected portions published 1919 ).
Lenzenweger, M.F. (1998). Schizotypy and schizotypic psychopathology: Mapping an alternative expression of schizophrenia liability. In M.F. Lenzenweger & R.H. Dworkin (Eds.), Origins and development of schizophrenia: Advances in experimental psychopathology (pp. 93 – 121 ). Washington, DC: American Psychological Association.
Lenzenweger, M.F., Jensen, S.T., and Rubin, D.B. (2001). Finding the “true” schizotype: On resolving heterogeneity in performance on bio-behavioral laboratory measures. Submitted toJournal of Abnormal Psychology.
Lenzenweger, M.F., and Korfine, L. (1994). Perceptual aberrations, schizotypy and the Wisconsin Card Sorting Test.Schizophrenia Bulletin20, 345 – 357.
Lenzenweger, M.F., Loranger, A.W., Korfine, L., and Neff, C. (1997). Detecting personality disorders in a nonclinical population: Application of a two-stage procedure for case identification.Archives of General Psychiatry54, 345 – 351.
Levy, DL., Holzman, PS., Matthysse. S., and Mendell, R. (1993). Eye tracking dysfunction and schizophrenia: A critical perspective. Schizophrenia Bulletin 19, 461–536.
O’Driscoll, G., Lenzenweger, M.F., and Holzman, P.S. (1998). Antisaccades and smooth pursuit eye tracking and schizotypy.Archives of General Psychiatry55, 837–843.
Park, S., Holzman, P.S., and Lenzenweger, M.F. (1995). Individual differ¬ences in working memory in relation to schizotypy.Journal of Abnormal Psychology104, 355–363.
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Jensen, S.T., Lenzenweger, M.F., Rubin, D.B. (2002). A Bayesian Approach to Reducing Heterogeneity in Laboratory Measures: An Illustration from Schizophrenia Research. In: Gatsonis, C., et al. Case Studies in Bayesian Statistics. Lecture Notes in Statistics, vol 167. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-2078-7_12
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DOI: https://doi.org/10.1007/978-1-4612-2078-7_12
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