Regulation of Apoptosis Versus Mitosis in Immature Granulosa Cells

  • David W. Schomberg
  • Jonathan L. Tilly
Part of the Proceedings in the Serono Symposia USA Series book series (SERONOSYMP)


Recent advances in the study of growth regulation at the cellular and molecular level have made it clear that “growth” of a tissue is the result of a tightly monitored and regulated balance between the processes of mitosis and apoptosis. Prior to this, studies of cell growth regulation in the ovarian follicle, as in other systems, emphasized the regulation of mitosis. Now, however, with the realization that apotosis is the fundamental cellular mechanism underlying the process of follicular atresia (1, 2), it is readily apparent that in order to understand the process of follicle selection we need to understand more about the regulation of both apoptosis and mitosis. In this chapter, studies will be reviewed that address both issues in the context of ovarian follicular growth. The focus will be to review the information relevant to the premise that regulatory hormones and growth factors act more effectively in combination to stimulate mitosis and to attenuate apoptosis.


Granulosa Cell Follicular Atresia Culture Granulosa Cell Porcine Granulosa Cell Mitotic Regulation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media New York 1997

Authors and Affiliations

  • David W. Schomberg
  • Jonathan L. Tilly

There are no affiliations available

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