Abstract
The controlled clinical trial is the most rigorous method we have to evaluate and compare alternative treatments. During the past three decades, controlled trials have almost replaced historical reviews or extensive personal experience as the basis for choosing treatment strategies.
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References
Butcher HR, Seaman WB, Eckert C, Saltzstein S. An Assessment of Radical Mastectomy and Postoperative Irradiation Therapy in the Treatment of Mammary Cancer. Cancer 1964;17:480–485
Paterson R, Russel MH. iClinical Trials in Malignant Disease: III. Breast Cancer: Evaluation of Postoperative Cadiotherapy. J Fac Radiol 1959;10:175–180
Balch CM, Murad TM, Soong S-J, Ingalls AL, Halpern NB, Maddox WA. A Multifactorial Analysis of Melanoma: Prognostic Histopathological Features Comparing Clark’s and Breslow’s Staging Methods. Ann Surg 1978;188:732–742
Balch CM. The Role of Elective Lymph Node Dissection in Melanoma: Rationale, Results, and Controversies. J Clin Oncol 1988;6:163–272
Chalmers TC, Block JB, Lee S. Controlled Studies in Clinical Cancer Research. New Engl J Med 1972; 287:75–78
Moertel CG. Improving the Efficiency of Clinical Frials: A Medical Perspective. Stat Med 1984;3:455–468
Gilbert JP, McPeek B, Mosteller F. Statistics and Ethics in Surgery and Anesthesia. Science 1977; 198: 684–689
Richardson WC. The Appropriate Scale of the Health Sciences Enterprise. Daedalus 1993;122:179–195
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Pollock, R.G., Balch, C.M., Holmes, E.C. (1998). Multicenter Collaborative Clinical Trials. In: Troidl, H., McKneally, M.F., Mulder, D.S., Wechsler, A.S., McPeek, B., Spitzer, W.O. (eds) Surgical Research. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1888-3_27
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DOI: https://doi.org/10.1007/978-1-4612-1888-3_27
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