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Inhibin, Activin and Follistatin pp 151–161Cite as

Evaluation of Maternal Serum Inhibin as a Marker for Complicated Pregnancy

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Part of the book series: Serono Symposia USA ((SERONOSYMP))

Abstract

Inhibin is a gonadal glycoprotein hormone composed of two dissimilar disulfide-linked subunits that inhibits preferentially the secretion and production of follicle-stimulating hormone (FSH) (1,2). Recent studies have revealed that in pregnant women immunoreactive and bioactive inhibin levels in the serum increased throughout pregnancy and decreased immediately after delivery (3–5). Gene expression and messenger RNA of inhibin have been detected in the human placenta (6,7), and high levels of immunoreactive and bioactive inhibin have been found in placenta cells and in placenta extracts (4,8,9). These results indicate that the placenta is an important source of inhibin in pregnancy.

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Authors
  1. Hideki Mizunuma
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  2. Yoshihisa Hasegawa
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  3. Yumiko Abe
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  4. Hiroko Nagatake
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  5. Yoshito Ibuki
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Editor information

Editors and Affiliations

  1. Department of Obstetrics and Gynecology School of Medicine, The University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima, 770, Japan

    Toshihiro Aono M.D., Ph.D. (Professor and Chairman) (Professor and Chairman)

  2. Division of Enzyme Cytology Institute for Enzyme Research, The University of Tokushima, 3-18-15, Kuramoto-cho, Tokushima, 770, Japan

    Hiromu Sugino Ph.D.

  3. The Clayton Foundation Laboratories for Peptide Biology, The Salk Institute, 10010 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Wylie W. Vale Ph.D.

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© 1997 Springer Science+Business Media New York

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Mizunuma, H., Hasegawa, Y., Abe, Y., Nagatake, H., Ibuki, Y. (1997). Evaluation of Maternal Serum Inhibin as a Marker for Complicated Pregnancy. In: Aono, T., Sugino, H., Vale, W.W. (eds) Inhibin, Activin and Follistatin. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1874-6_14

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  • DOI: https://doi.org/10.1007/978-1-4612-1874-6_14

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7320-2

  • Online ISBN: 978-1-4612-1874-6

  • eBook Packages: Springer Book Archive

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