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Biochemical Messengers in Postsurgical Repair and Adhesion Formation

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Pelvic Surgery

Abstract

Adhesion formation may be the result of prolonged deposition of excess fibrin, which is produced during coagulation and restoration of vascular hemostasis.1 The ability to remove deposited fibrin is dependent on the postsurgical environment and the cellular milieu. At surgery, multifaceted insults may be delivered to the tissue that will modulate the process of postsurgical fibrinolysis and repair. These may include (1) the disruption of the tissue architecture; (2) removal of cells from the surface of tissues by abrasion or drying; (3) disruption of vascular integrity; and (4) the introduction of foreign bodies. However, as a result of any surgical injury, an inflammatory response is initiated that allows the deposition of fibrin and may modulate the removal of the deposited fibrin.

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  1. Kathleen E. Rodgers
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Editors and Affiliations

  1. Department of Obstetrics and Gynecology, Livingston Laboratories, University of Southern California, 90033, Los Angeles, CA, USA

    Gere S. diZerega M.D.

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Rodgers, K.E. (1997). Biochemical Messengers in Postsurgical Repair and Adhesion Formation. In: diZerega, G.S., et al. Pelvic Surgery. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1864-7_2

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  • DOI: https://doi.org/10.1007/978-1-4612-1864-7_2

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7316-5

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