“Each man in this room is half the man his grandfather was.” These were the words recently quoted during a Congressional hearing reporting the startling and controversial finding that a serious decline in the quality and quantity of human spermatozoa has occurred over the past 50 years.1 Another report from Scotland revealed that men born after 1970 had a sperm count 25% lower than those born before 1959—an average decline of 2.1% a year. The lower sperm count was also associated with poor semen quality.2 In contrast, Olsen et al,3 using several statistical models, found an actual increase in average sperm number. These data have led some scientists and environmentalists to believe that the human species is approaching a fertility crisis, but others think that the available data are insufficient to deduce worldwide conclusions.4,5 Nevertheless, the topic of gonadotoxicity remains a real challenge and concern to almost everyone.


Germ Cell Sertoli Cell Leydig Cell Male Infertility Semen Quality 
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© Springer Science+Business Media New York 1997

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  • Suresh C. Sikka

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