Skip to main content

Part of the book series: Contemporary Endocrinology ((COE,volume 7))

Abstract

Gastrointestinal symptoms are common among diabetic patients (1), although this is also true for the general population. In fact, it is not established by appropriate population studies whether the prevalence of gastrointestinal symptoms in diabetic patients is actually increased. What is clear is that a segment of the diabetic population presents gastrointestinal symptoms that can be related to specific physiologic gut dysfunctions. Interestingly, some diabetic patients without gastrointestinal symptoms may sometimes evidence physiological abnormalities (such as gastric stasis or anorectal dysfunction) at the subclinical level (2). One reason why it is so difficult to ascertain whether diabetic patients have more symptoms referable to the digestive tract than the general population is because the nature of the symptomatology, which coincides with that of individuals with common functional-type abdominal disorders. Only when gastrointestinal symptoms in a diabetic can be attached to a specific physiological abnormality caused by neuromuscular dysfunction is the clinician reasonably certain that he or she is dealing with a gut diabetic syndrome. Unfortunately this is not usually the case for most diabetic patients complaining about gastrointestinal symptoms in whom the relation between the diabetes and their digestive ailment remains presumptive at best, since physiological studies are only undertaken in patients with severe and disabling symptoms. Clinicians should, therefore, refrain from ascribing digestive symptoms to diabetes without further evidence than simple association.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Feldman M, Schiller LR. Disorders of gastrointestinal motility associated with diabetes mellitus. Ann Intern Med 1983;98:378.

    PubMed  CAS  Google Scholar 

  2. Kassander P. Asymptomatic gastric retention in diabetes (gastroparesis diabeticorum). Ann Intern Med 1958;48:797.

    PubMed  CAS  Google Scholar 

  3. Wald A, Tunuguntla AK. Anorectal sensorimotor dysfunction in fecal incontinence and diabetes mellitus. Modification with biofeedback therapy. N Engl J Med 1984;310:1282.

    Google Scholar 

  4. Whalen GE, Soergel KH, Geenen JE. Diabetic diarrhoea. A clinical and pathological study. Gastroenterology 1969;56:1021.

    PubMed  CAS  Google Scholar 

  5. Lincoln J, Bokor JT, Crowe R, Griffith SG, Haven AJ, Burnstock G. Myenteric plexus in streptozotocin-treated rats. Neurochemical and histochemical evidence for diabetic neuropathy in the gut. Gastroenterology 1984;86:654.

    CAS  Google Scholar 

  6. Russell COH, Gannon R, Coatsworth J, et al. Relationship among esophageal dysfunction, diabetic gastroenteropathy, and peripheral neuropathy. Dig Dis Sci 1983;28:289

    Article  PubMed  CAS  Google Scholar 

  7. Stewart IM, Hosking DG, Preston BJ, Atkinson M. Esophageal motor changes in diabetes mellitus. Thorax 1976;31:278.

    Article  PubMed  CAS  Google Scholar 

  8. Clouse RE, Reidel WL, Lustman PJ. Correlation of esophageal motility abnormalities with neuropsychiatric states in diabetic patients (abstract). Gastroenterology 1985;88:1351.

    Google Scholar 

  9. Hollis JB, Castell DO, Braddom RL. Esophageal function in diabetes mellitus and its relation to peripheral neuropathy. Gastroenterology 1977;73:1098.

    PubMed  CAS  Google Scholar 

  10. Abrahamsson H. Gastrointestinal motility disorders in patients with diabetes mellitus. J Intern Med 1995;237(4):403–409.

    Article  PubMed  CAS  Google Scholar 

  11. Zitomer BR, Gramm HF, Kozak GP. Gastric neuropathy in diabetes mellitus: clinical and radiologie observations. Metabolism 1968; 17:199.

    Article  PubMed  CAS  Google Scholar 

  12. Camilleri M, Malagelada J-R. Abnormal intestinal motility in diabetic patients with the gastroparesis syndrome. Eur J Clin Invest 1984; 14:420.

    Article  PubMed  CAS  Google Scholar 

  13. Malagelada J-R, Rees WDR, Mazzotta LJ, Go VLW. Gastric motor abnormalities in diabetic and postvagotomy gastroparesis: effect of metoclopramide and bethanechol. Gastroenterology 1980;78:286.

    PubMed  CAS  Google Scholar 

  14. Malagelada J-R, Stanghellini V. Manometric evaluation of upper gut symptoms. Gastroenterology 1985;88:1223.

    PubMed  CAS  Google Scholar 

  15. Undeland KA, Hausken T, Svebak S, Aanderud S, Berstad A. Wide gastric antrum and low vagal tone in patients with diabetes mellitus type I compared to patients with functional dyspepsia and healthy individuals. Dig Dis Sci 1996;41(1):9–16.

    Article  PubMed  CAS  Google Scholar 

  16. Jenkinson KM, Reid JJ. Effect of diabetes on relaxations to nonadrenergic, noncholinergic nerve stimulation in longitudinal muscle of the rat gastric fundus. Br J Pharmacol 1995; 116(1): 1551–1556.

    Article  PubMed  CAS  Google Scholar 

  17. Jebbink HJA, Bruijs PPM, Bravenboer B, Akkermans LMA, Vanberge-Henegouwen, GP, Smout AJPM. Gastric myoelectrical activity in patients with type I diabetes mellitus and autonomic neuropathy. Dig Dis Sci 1994;39(11):2376–2383.

    Article  PubMed  CAS  Google Scholar 

  18. Samson M, Salet GAM, Roelofs JMM, Akkermans LMA, Vanberge-Henegouwen GP, Smout AJPM. Compliance of the proximal stomach and dyspeptic symptoms in patients with type I diabetes mellitus. Dig Dis Sci 1995;40(9):2037–2042.

    Article  Google Scholar 

  19. Thomforde GM, Brown ML, Malagelada J-R. Practical solid and liquid phase markers for studying gastric emptying in man. J Nucl Med Technol 1985; 13:11.

    Google Scholar 

  20. Frank JW, Saslow SB, Camilleri M, Thomforde GM, Dinnen S, Rizza, RA. Mechanism of accelerated gastric emptying of liquids and hyperglycemia in patients with type II diabetes mellitus. Gastroenterology 1995;109(3):755–765.

    Article  PubMed  CAS  Google Scholar 

  21. Wright RA, Clemente R, Wathen R. Diabetic gastroparesis: an abnormality of gastric emptying of solids. Am J Med Sci 1985;289:240.

    Article  PubMed  CAS  Google Scholar 

  22. Nowak TV, Johnson CP, Kalbfleisch JH, Roza AM, Wood CM, Weisbruch JP, Soergel KH. Highly variable gastric emptying in patients with insulin dependent diabetes mellitus. Gut 1995;37(1):23–29.

    Article  PubMed  CAS  Google Scholar 

  23. Abell TL, Camilleri M, Malagelada J-R. High prevalence of gastric electrical dysrhythmias in diabetic gastroparesis (abstract). Gastroenterology 1985;88:1299.

    Google Scholar 

  24. Low PA, Walsh JC, Huang CY, McLeod JC. The sympathetic nervous system in diabetic neuropathy: a clinical and pathological study. Brain 1975;98:341.

    Article  PubMed  CAS  Google Scholar 

  25. Hensley GT, Soergel KH. Neuropathologic findings in diabetic diarrhoea. Arch Pathol 1968;85:587.

    PubMed  CAS  Google Scholar 

  26. Schmidt RE, Nelson JS, Johnson EM. Experimental diabetic autonomie neuropathy. Am J Pathol 1981;103:210.

    PubMed  CAS  Google Scholar 

  27. Schmidt H, Riemann JF, Schmid A, Sailer D. Ultrastructure of diabetic microangiopathy and autonomic neuropathy of the gut (abstract). Gastroenterology 1984;86:1236.

    Google Scholar 

  28. Bo-Linn G, Fordtran JS. Fecal fat concentration in patients with steatorrhea. Gastroenterology 1984;87:319.

    PubMed  CAS  Google Scholar 

  29. Battle WM, Snape WJ, Alavi A, Cohen S, Braunstein S. Colonie dysfunction in diabetes mellitus. Gastroenterology 1980;79:1217.

    PubMed  CAS  Google Scholar 

  30. Katz LA, Spiro HM. Gastrointestinal manifestations of diabetes. N Engl J Med 1966;275:1350.

    Article  PubMed  CAS  Google Scholar 

  31. Schiller LR, Santa Ana CA, Schmulen AC, Hendler RS, Harford WV, Fordtran, JS. Pathogenesis of fecal incontinence in diabetes mellitus. Evidence for internal anal sphincter dysfunction. N Engl J Med 1982;307:1666.

    Article  PubMed  CAS  Google Scholar 

  32. Read NW, Haynes WG, Bartolo DCC, et al. Use of anorectal manometry during rectal infusion of saline to investigate sphincteric function in incontinent patients. Gastroenterology 85:105.

    Google Scholar 

  33. Wald A. Biofeedback therapy for fecal incontinence. Ann Intern Med 1981;95:146.

    PubMed  CAS  Google Scholar 

  34. Desautels SG, Hutson WR, Christian PE, Moore JG, Datz FL. Gastric emptying response to variable oral erythromycin dosing in diabetic gastroparesis. Dig Dis Sci 1995;40(l):141–146.

    Article  PubMed  CAS  Google Scholar 

  35. Mansi C, Savarino V, Vigneri S, Perilli D, Melga P, Sciabè L, De Martini D, Mela GS. Gastrokinetic effects of levosulpiride in dyspeptic patients with diabetic gastroparesis. Am J Gastroenterol 1995;90(11):1989–1993.

    PubMed  CAS  Google Scholar 

  36. Fontana RJ, Barnett JL. Jejunostomy tube placement in refractory diabetic gastroparesis: a retrospective review. Am J Gastroenterol 1996;91(10):2174–2178.

    PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1998 Springer Science+Business Media New York

About this chapter

Cite this chapter

Malagelada, JR. (1998). Gastrointestinal Disorders. In: Veves, A. (eds) Clinical Management of Diabetic Neuropathy. Contemporary Endocrinology, vol 7. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-1816-6_15

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-1816-6_15

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-7296-0

  • Online ISBN: 978-1-4612-1816-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics