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Clues from Experimental Models

  • Daniel S. Longnecker

Abstract

Selecting or creating an animal model of carcinoma of the pancreas is a complex process. One must ask what is being modeled. The reflex response is “ductal adenocarcinoma,” because this is the most common histologic type of pancreatic cancer. However, a recently revised classification of neoplasms of the exocrine pancreas in humans lists 17 major types and 11 subtypes (1). These are grouped into three categories according to clinical behavior (benign, borderline, and malignant). The complexity is reduced somewhat by the fact that several histologic phenotypes have benign or borderline and malignant counterparts that apparently represent sequential steps in the development of a fully malignant phenotype. For example, one group includes mucinous cystadenoma, mucinous cystic tumor with moderate dysplasia, and mucinous cystadenocarcinoma. In such cases, one might anticipate that a single animal model would cover the spectrum of several types of human tumors.

Keywords

Acinar Cell Pancreatic Carcinoma Acinar Cell Carcinoma Mucinous Cystic Tumor Syrian Golden Hamster 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 1998

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  • Daniel S. Longnecker

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