Primary Biliary Cirrhosis and Primary Sclerosing Cholangitis

  • Edward P. Toffolon
Part of the Current Clinical Practice book series (CCP)


Cholestasis (literally the stoppage of bile) has a variety of operational definitions. To the clinician, it is the jaundiced patient with marked elevations of alkaline phosphatase and minimally elevated aminotransferases. To the physiologist, it is the measurable decrease in hepatic secretion of water and solutes. To the histopathologist, it is the identification of bile pigment in the canaliculi, bile ducts or hepatocytes. Cholestasis results from an interference in normal bile flow. This interference may occur at any point from the canalicular membrane of the hepatocyte to the ampulla of Vater in the duodenal wall. Clinical manifestations of cholestasis range from asymptomatic abnormalities in liver function tests to fatigue, pruritus, jaundice, and right upper quadrant pain.


Bile Duct Bile Acid Ulcerative Colitis Primary Biliary Cirrhosis Primary SCLEROSING Cholangitis 
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Suggested Reading

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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Edward P. Toffolon

There are no affiliations available

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