Ultrastructure of the Striated Muscle Cell

  • Robert G. McCord
  • Allen W. Clark
Part of the Pathology and Laboratory Medicine book series (PLM)


The succeeding chapters deal with the biochemistry and clinical utilization of cardiac markers. This chapter deals with the source of these markers as they are released into the blood following injury. To appreciate this, a knowledge of cell anatomy at the ultrastructural level is necessary. Over the past 50 yr, two technologies have evolved that have enabled us to understand cell structure by providing details not possible with the light microscope. These investigative tools are the electron microscope (EM*) and X-ray diffraction. The former has elucidated the substructure of muscle fibers as seen with routine histology (or polarizing optics), whereas the latter has given us knowledge about the molecular structure of the muscular contractile apparatus (1,2).


Thin Filament Glycogen Phosphorylase Thick Filament Intercalate Disk Myosin Molecule 
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  1. 1.
    Fawcett DW (1994) Bloom and Fawcett: A Textbook of Histology, Chapman & Hall, New York.Google Scholar
  2. 2.
    Squire J (1981) The Structural Basis of Muscular Contraction, Plenum Press, New York.CrossRefGoogle Scholar
  3. 3.
    Cormack DH (1993) Essential Histology, J. B. Lippincott Company, Philadelphia, PA.Google Scholar
  4. 4.
    Junqueira LC et al. (1995) Basic Histology, Appleton & Lange, Stamford, CT.Google Scholar
  5. 5.
    Ventura-Clapier R, Veksler V, and Hoerter JA (1994) Myofibrillar creatine kinase and cardiac contraction. Mol. Cell Biochem. 133/134:125–144.PubMedCrossRefGoogle Scholar
  6. 6.
    Franchi LL, Murdoch A, Brown WE, et al. (1990) Subcellular localisation of newly incorporated myosin in rabbit fast skeletal muscle undergoing stimulation-induced type transformation. J. Musc. Res. Cell. Motil. 11:227–239.CrossRefGoogle Scholar
  7. 7.
    Huxley AF and Nierdergerke R (1954) Structural changes in muscle during contraction. Interference microscopy of living muscle fibers. Nature 173:971–973.PubMedCrossRefGoogle Scholar
  8. 8.
    Jorgensen AO, Shen ACY, Campbell KP, and MacClennan DH (1983) Ultrastructural localization of calsequestrin in rat skeletal muscle by immunoferritin labeling of ultrathin frozen selections. J. Cell Biol. 97:1573–1581.PubMedCrossRefGoogle Scholar
  9. 9.
    Cuenda A, Nogues M, Gutierrez-Merino C, and de Meis L (1993) Glycogen phospho-rolysis can form a metabolic shuttle to support Ca2+ uptake by sarcoplasmic reticulum membranes in skeletal muscle. Biochem. Biophys. Res. Commun. 196:1127–1132.PubMedCrossRefGoogle Scholar
  10. 10.
    Cuenda A, Henao F, Nogues M, and Gutierrez-Merino C (1994) Quantification and removal of glycogen phosphorylase and other enzymes associated with sarcoplasmic reticulum membrane preparations. Biochim. Biophys. Acta. 1194:35–43.PubMedCrossRefGoogle Scholar
  11. 11.
    Ganong WF (1995) Review of Medical Physiology, Appleton & Lange, Stamford, CT.Google Scholar
  12. 12.
    Ebashi S, Endo M, and Ohtsuki I (1969) Control of muscle contraction. Q. Rev. Biophys. 2:351–384.PubMedCrossRefGoogle Scholar
  13. 13.
    Block BA, Imagawa T, Campbell KP, and Franzini-Armstrong C (1988) Structural evidence for direct interaction between the molecular components of the transverse tubule/sarcoplasmic reticulum junction in skeletal muscle. J. Cell Biol. 107: 2587–2600.PubMedCrossRefGoogle Scholar
  14. 14.
    Goodman, SR (1994) Medical Cell Biology, J. B. Lippincott Company, New York.Google Scholar
  15. 15.
    Kawai H, Nishino H, Nishida Y, et al. (1987) Localization of myoglobin in human muscle cells by immunoelectron microscopy. Muscle & Nerve 10:144–149.CrossRefGoogle Scholar
  16. 16.
    Widnell CC and Pfenninger KH (1990) Essential Cell Biology, Williams & Wilkins, Baltimore, MD.Google Scholar
  17. 17.
    Willerson JT (1995) Cardiovascular Medicine, Churchill Livingstone, New York.Google Scholar

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© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Robert G. McCord
  • Allen W. Clark

There are no affiliations available

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