The Rodent Placental Prolactin Family and Pregnancy

  • Michael J. Soares
  • Guoli Dai
  • Christopher B. Cohick
  • Heiner Müller
  • Kyle E. Orwig
Part of the Contemporary Endocrinology book series (COE, volume 9)

Abstract

Endocrine signals produced by the placenta have a pivotal role in the establishment and maintenance of pregnancy. These signals include hormones, cytokines, and growth factors that act to coordinate events in maternal, extraembryonic, and embryonic compartments. Among the various regulatory signals secreted by the placenta are a prominent family of proteins related to pituitary prolactin (PRL). These proteins have amassed a rich history of investigation in several species.

Keywords

Carbohydrate Estrogen Cysteine Glucocorticoid Progesterone 

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References

  1. 1.
    Ogren L, Talamantes F (1988) Prolactins of pregnancy and their cellular source. Int Rev Cytol 112:1–65.PubMedCrossRefGoogle Scholar
  2. 2.
    Soares MJ, Faria TN, Roby KF, Deb S (1991) Pregnancy and the prolactin family of hormones: coordination of anterior pituitary, uterine, and placental expression. Endocr Rev 12:402–423.PubMedCrossRefGoogle Scholar
  3. 3.
    Soares MJ, Faria TN, Hamlin GP, Lu XJ, Deb S (1993) Trophoblast cell differentiation: expression of the placental prolactin family, In: Trophoblast Cells: Pathways for Maternal-Embryonic Communication (Soares MJ, Handwerger S, Talamantes F, eds.), Springer-Verlag, New York, pp. 45–67.Google Scholar
  4. 4.
    Soares MJ, Chapman BM, Rasmussen CA, Dai G, Kamei T, Orwig KE (1996) Differentiation of trophoblast endocrine cells. Placenta 17:277–289.PubMedCrossRefGoogle Scholar
  5. 5.
    Orwig KE, Rasmussen CA, Soares MJ (1997) Decidual signals in the establishment of pregnancy: the prolactin family. Trophoblast Res 10:329–343.Google Scholar
  6. 6.
    Duckworth ML, Robertson MC, Schroedter IC, Szpirer C, Friesen HG (1993) Molecular genetics and biology of the rat placental prolactin family, In: Trophoblast Cells: Pathways for Maternal-Embryonic Communication (Soares MJ, Handwerger S, Talamantes F, eds.), Springer-Verlag, New York, pp. 169–190.Google Scholar
  7. 7.
    Nicoll CS, Mayer GL, Russell SM (1986) Structural features of prolactins and growth hormones that can be related to their biological properties. Endocr Rev 7:169–203.PubMedCrossRefGoogle Scholar
  8. 8.
    Shiu RPC, Kelly PA, Friesen HG (1973) Radioreceptor assay for prolactin and other lactogenic hormones. Science 180:968–971.PubMedCrossRefGoogle Scholar
  9. 9.
    Tanaka T, Shiu RPC, Gout PW, Beer CT, Noble RL, Friesen HG (1980) A new sensitive and specific bioassay for lactogenic hormones: measurement of prolactin and growth hormone in human serum. J Clin Endocrinol Metab 51:1058–1062.PubMedCrossRefGoogle Scholar
  10. 10.
    Southard JN, Talamantes F (1991) Placental prolactin-like proteins in rodents: variations on a structural theme. Mol Cell Endocrinol 79:C133–C140.PubMedCrossRefGoogle Scholar
  11. 11.
    Talamantes F (1975) Comparative study of the occurrence of placental prolactin among mammals. Gen Comp Endocrinol 27:115–121.PubMedCrossRefGoogle Scholar
  12. 12.
    Kelly PA, Tsushima T, Shiu RPC, Friesen HG (1976) Lactogenic and growth hormone-like activities in pregnancy determined by radioreceptor assays. Endocrinology 99:765–774.PubMedCrossRefGoogle Scholar
  13. 13.
    Enders AC (1965) A comparative study of the fine structure of the trophoblast in several hemochorial placentas. Am J Anat 116:29–67.PubMedCrossRefGoogle Scholar
  14. 14.
    Soares MJ, Chapman BM, Kamei T, Yamamoto T (1995) Control of trophoblast cell differentiation: lessons from the genetics of early pregnancy loss and trophoblast neoplasia. Dev Growth Differ 37:355–364.CrossRefGoogle Scholar
  15. 15.
    Sibley CP (1994) Mechanisms of ion transfer by the rat placenta: a model for the human placenta? Placenta 15:675–691.PubMedCrossRefGoogle Scholar
  16. 16.
    Teshima S, Shimosato Y, Koide T, Kuroki M, Kikuchi Y, Aizawa M (1983) Transplantable choriocarcinoma of rats induced by fetectomy and its biological activities. Gann 74:205–212.PubMedGoogle Scholar
  17. 17.
    Faria TN, Soares MJ (1991) Trophoblast cell differentiation: establishment, characterization, and modulation of a rat trophoblast cell line expressing members of the placental prolactin family. Endocrinology 129:2895–2906.PubMedCrossRefGoogle Scholar
  18. 18.
    Hamlin GP, Soares MJ (1995) Regulation of DNA synthesis in proliferating and differentiating trophoblast cells: involvement of transferrin, transforming growth factor-beta, and tyrosine kinases. Endocrinology 136:322–331.PubMedCrossRefGoogle Scholar
  19. 19.
    Hamlin GP, Lu X-J, Roby KF, Soares MJ (1994) Recapitulation of the pathway for trophoblast giant cell differentiation in vitro: stage-specific expression of members of the prolactin gene family. Endocrinology 134:2390–2396.PubMedCrossRefGoogle Scholar
  20. 20.
    Yamamoto T, Roby KF, Kwok SCM, Soares MJ (1994) Transcriptional activation of cytochrome P450 side chain cleavage enzyme expression during trophoblast cell differentiation. J Biol Chem 269:6517–6523.PubMedGoogle Scholar
  21. 21.
    Yamamoto T, Chapman BM, Clemens JW, Richards JS, Soares MJ (1995) Analysis of cytochrome P450 side-chain cleavage gene promoter activation during trophoblast cell differentiation. Mol Cell Endocrinol 113:183–194.PubMedCrossRefGoogle Scholar
  22. 22.
    Yamamoto T, Chapman BM, Johnson DC, Givens CR, Mellon SH, Soares MJ (1996) Cytochrome P450 17alpha-hydroxylase gene expression in differentiating rat trophoblast cells. J Endocrinol 150:161–168.PubMedCrossRefGoogle Scholar
  23. 23.
    Kelly PA, Shiu RPC, Robertson MC, Friesen HG (1975) Characterization of rat chorionic mammotropin. Endocrinology 96:1187–1195.PubMedCrossRefGoogle Scholar
  24. 24.
    Robertson MC, Friesen HG (1981) Two forms of rat placental lactogen revealed by radioimmunoassay. Endocrinology 108:2388–2390.PubMedCrossRefGoogle Scholar
  25. 25.
    Robertson MC, Gillespie B, Friesen HG (1982) Characterization of the two forms of rat placental lactogen (rPL): rPL-I and rPL-II. Endocrinology 111:1862–1866.PubMedCrossRefGoogle Scholar
  26. 26.
    Soares MJ, Colosi P, Talamantes F (1982) The development and characterization of a homologous radioimmunoassay for mouse placental lactogen. Endocrinology 110:668–670.PubMedCrossRefGoogle Scholar
  27. 27.
    Soares MJ, Colosi P, Ogren L, Talamantes F (1983) Identification and partial characterization of a lactogen from the midpregnant mouse conceptus. Endocrinology 112:1313–1317.PubMedCrossRefGoogle Scholar
  28. 28.
    Southard JN, Campbell GT, Talamantes F (1987) Hamster placental lactogens: gestational profiles and high mol-wt forms. Endocrinology 121:900–906.PubMedCrossRefGoogle Scholar
  29. 29.
    Soares MJ, Julian JA, Glasser SR (1985) Trophoblast giant cell release of placental lactogens: temporal and regional characteristics. Dev Biol 107:520–526.PubMedCrossRefGoogle Scholar
  30. 30.
    Colosi P, Ogren L, Thordarson G, Talamantes F (1987) Purification and partial characterization of two prolactin-like glycoprotein hormone complexes from the midpregnant mouse conceptus. Endocrinology 120:2500–2511.PubMedCrossRefGoogle Scholar
  31. 31.
    Colosi P, Talamantes F, Linzer DIH (1987) Molecular cloning and expression of mouse placental lactogen I complementary deoxyribonucleic acid. Mol Endocrinol 1:767–776.PubMedCrossRefGoogle Scholar
  32. 32.
    Robertson MC, Croze F, Schroedter IC, Friesen HG (1990) Molecular cloning and expression of rat placental lactogen-I complementary deoxyribonucleic acid. Endocrinology 127:702–710.PubMedCrossRefGoogle Scholar
  33. 33.
    Hirosawa M, Miura R, Min KS, Hattori N, Shiota K, Ogawa T (1994) A cDNA encoding a new member of the rat placental lactogen family, PL-I mosaic (PL-Im). Endocr J 41:387–397.PubMedCrossRefGoogle Scholar
  34. 34.
    Dai G, Imagawa W, Liu B, Szpirer C, Levan G, Kwok SCM, Soares MJ (1996) Rcho-1 trophoblast cell placental lactogens: complementary DNAs, heterologous expression, and biological activities. Endocrinology 137:5020–5027.PubMedCrossRefGoogle Scholar
  35. 35.
    Deb S, Faria TN, Roby KF, Larsen D, Kwok SCM, Talamantes F, Soares MJ (1991) Identification and characterization of a new member of the prolactin family, placental lactogen-I variant. J Biol Chem 266:1605–1610.PubMedGoogle Scholar
  36. 36.
    Shida MM, Ng Y-K, Soares MJ, Linzer DIH (1993) Trophoblast-specific transcription from the mouse placental lactogen-I gene promoter. Mol Endocrinol 7:181–188.PubMedCrossRefGoogle Scholar
  37. 37.
    Nieder GL, Jennes L (1990) Production of mouse placental lactogen-I by trophoblast giant cells in utero and in vitro. Endocrinology 126:2809–2814.PubMedCrossRefGoogle Scholar
  38. 38.
    Faria TN, Deb S, Kwok SCM, Talamantes F, Soares MJ (1990) Ontogeny of placental lactogen-I and placental lactogen-II expression in the developing rat placenta. Dev Biol 141:279–291.PubMedCrossRefGoogle Scholar
  39. 39.
    Faria TN, Ogren L, Talamantes F, Linzer DIH, Soares MJ (1991) Localization of placental lactogen-I in trophoblast giant cells of the mouse placenta. Biol Reprod 44:327–331.PubMedCrossRefGoogle Scholar
  40. 40.
    Carney EW, Prideaux V, Lye SJ, Rossant J (1993) Progressive expression of trophoblast specific genes during formation of mouse trophoblast giant cells in vitro. Mol Reprod Dev 34:357–368.PubMedCrossRefGoogle Scholar
  41. 41.
    Lopez MF, Carrion FA, Talamantes F (1992) Pituitary-placental interaction: hypophysectomy modulates the secretion of mouse placental lactogen-I. Endocrinology 129:2325–2328.CrossRefGoogle Scholar
  42. 42.
    Lopez MF, Ogren L, Linzer DIH, Talamantes F (1993) Pituitary-placental interaction during pregnancy: regulation of prolactin-like proteins. Endocr J 1:513–518.Google Scholar
  43. 43.
    Yamaguchi M, Miyake A (1996) Regulation of mouse placental lactogen secretion by factors secreted from the pituitary in vitro. Eur J Endocrinol 134:123–127.PubMedCrossRefGoogle Scholar
  44. 44.
    Yamaguchi M, Endo H, Thordarson G, Ogren L, Talamantes F (1992) Modulation of mouse placental lactogen-I secretion in vitro: effects of progesterone and mouse placental lactogen-II. Endocrinology 130:2897–2905.PubMedCrossRefGoogle Scholar
  45. 45.
    Yamaguchi M, Ogren L, Endo H, Thordarson G, Kensinger R, Talamantes F (1992) Epidermal growth factor stimulates mouse placental lactogen I but inhibits mouse placental lactogen II secretion in vitro. Proc Natl Acad Sci USA 89:11,396-11,400.CrossRefGoogle Scholar
  46. 46.
    Yamaguchi M, Taga T, Kishimoto T, Miyake A (1995) Cytokines that use gp130 as a signal transducer stimulate mouse placental lactogen-I (mPL-I) but inhibit mPL-II production in vitro. Biol Reprod 53:399–406.PubMedCrossRefGoogle Scholar
  47. 47.
    Yamaguchi M, Ogren L, Kurachi H, Hirota K, Imai T, Talamantes F (1995) Opposite effects of transforming growth factor alpha and epidermal growth factor on mouse placental lactogen I secretion. Proc Natl Acad Sci USA 92:2830–2834.PubMedCrossRefGoogle Scholar
  48. 48.
    Yamaguchi M, Imai T, Maeda T, Sakata M, Miyake A (1995) Cyclic adenosine-3′,5′-monophos-phate stimulates mouse placental lactogen-I (mPL-I) secretion but inhibits mPL-II secretion at midpregnancy. Endocrinology 136:1388–1393.PubMedCrossRefGoogle Scholar
  49. 49.
    Yamaguchi M, Miyake A (1996) Regulation of mouse placental lactogen secretion by G proteins before midpregnancy. J Endocrinol Invest 19:492–498.PubMedGoogle Scholar
  50. 50.
    Ng Y-K, George KM, Engel JD, Linzer DIH (1994) GATA factor activity is required for the trophoblast-specific transcriptional regulation of the mouse placental lactogen I gene. Development 120:3257–3266.PubMedGoogle Scholar
  51. 51.
    Ma G, Roth M, Groskopf JC, Tsai F-Y, Orkin SH, Grosveld F, Engel JD, Linzer DIH (1997) GATA-2 and GATA-3 regulate trophoblast-specific gene expression in vivo. Development 124:907–914.PubMedGoogle Scholar
  52. 52.
    Cross JC, Flannery ML, Blanar MA, Steingrimmission E, Jenkins NA, Copeland NG, Rutter WJ, Werb Z (1995) Hxt encodes a basic helix-loop-helix transcription factor that regulates trophoblast cell development. Development 121:2513–2523.PubMedGoogle Scholar
  53. 53.
    Cserjesi P, Brown D, Lyons GE, Olson EN (1995) Expression of the novel basic helix-loop-helix gene eHAND in neural crest derivatives and extraembryonic membranes during mouse development. Dev Biol 170:664–678.PubMedCrossRefGoogle Scholar
  54. 54.
    Hollenberg SM, Sternglanz R, Cheng PF, Weintraub H (1995) Identification of a new family of tissue-specific basic helix-loop-helix proteins with a two-hybrid system. Mol Cell Biol 15:3813–3822.PubMedGoogle Scholar
  55. 55.
    Ogren L, Southard JN, Colosi P, Linzer DIH, Talamantes F (1989) Mouse placental lactogen-I: RIA and gestational profile in maternal serum. Endocrinology 125:2253–2257.PubMedCrossRefGoogle Scholar
  56. 56.
    Robertson MC, Cosby H, Fresnoza A, Cattini PA, Shiu RPC, Friesen HG (1994) Expression, purification, and characterization of recombinant rat placental lactogen-I: a comparison with the native hormone. Endocrinology 134:393–400.PubMedCrossRefGoogle Scholar
  57. 57.
    Bridges RS, Robertson MC, Shiu RPC, Friesen HG, Stuer AM, Mann PE (1996) Endocrine communication between conceptus and mother: placental lactogen stimulation of maternal behavior. Neuroendocrinology 64:57–64.PubMedCrossRefGoogle Scholar
  58. 58.
    Colosi P, Ogren L, Southard JN, Thordarson G, Linzer DIH, Talamantes F (1988) Biological, immunological, and binding properties of recombinant mouse placental lactogen-I. Endocrinology 123:2662–2667.PubMedCrossRefGoogle Scholar
  59. 59.
    Freemark M, Kirk K, Pihoker C, Robertson MC, Shiu RPC, Driscoll P (1993) Pregnancy lactogens in the rat conceptus and fetus: circulating levels, distribution of binding, and expression of receptor messenger ribonucleic acid. Endocrinology 133:1830–1842.PubMedCrossRefGoogle Scholar
  60. 60.
    Freemark M, Kirk K, Robertson MC (1994) Cellular distribution of placental lactogen binding sites in the pregnant rat. Endocr J 2:199–205.Google Scholar
  61. 61.
    MacLeod KR, Smith WC, Ogren L, Talamantes F (1989) Recombinant mouse placental lactogen-I binds to lactogen receptors in mouse liver and ovary: partial characterization of the ovarian receptor. Endocrinology 125:2258–2266.PubMedCrossRefGoogle Scholar
  62. 62.
    Pihoker C, Robertson MC, Freemark M (1993) Rat placental lactogen-I binds to the choroid plexus and hypothalamus of the pregnant rat. J Endocrinol 139:235–242.PubMedCrossRefGoogle Scholar
  63. 63.
    Fielder PJ, Thordarson G, English A, Rosenfeld RG, Talamantes F (1992) Expression of a lactogen-dependent insulin-like growth factor-binding protein in cultured mouse mammary epithelial cells. Endocrinology 131:261–267.PubMedCrossRefGoogle Scholar
  64. 64.
    Brelje TC, Scharp DW, Lacy PE, Ogren L, Talamantes F, Robertson M, Friesen HG, Sorenson RL (1993) Effect of homologous placental lactogens, prolactins, and growth hormones on islet B-cell division and insulin secretion in rat, mouse, and human islets: implication for placental lactogen regulation of islets function during pregnancy. Endocrinology 132:879–887.PubMedCrossRefGoogle Scholar
  65. 65.
    Galosy SS, Talamantes F (1995) Luteotropic actions of placental lactogens at midpregnancy in the mouse. Endocrinology 136:3993–4003.PubMedCrossRefGoogle Scholar
  66. 66.
    Bridges RS, Roberston MC, Shiu RPC, Sturgis JD, Henriquesz BM, Mann PE (1997) Central lactogenic regulation of maternal behavior in rats: steroid dependence, hormone specificity, and behavioral potencies of rat prolactin and rat placental lactogen I. Endocrinology 138:756–763.PubMedCrossRefGoogle Scholar
  67. 67.
    Voogt JL, Soares MJ, Robertson MC, Arbogast LA (1996) Rat placental lactogen-I abolishes nocturnal prolactin surges in the pregnant rat. Endocrine 4:233–238.PubMedCrossRefGoogle Scholar
  68. 68.
    Cohick CB, Dai G, Xu L, Deb S, Kamei T, Levan G, Szpirer C, Szpirer J, Kwok SCM, Soares MJ (1996) Placental lactogen-I variant utilizes the prolactin receptor signaling pathway. Mol Cell Endocrinol 116:49–58.PubMedCrossRefGoogle Scholar
  69. 69.
    Robertson MC, Schroedter IC, Friesen HG (1991) Molecular cloning and expression of rat placental lactogen-Iv, a variant of rPL-I present in late pregnant rat placenta. Endocrinology 129:2746–2756.PubMedCrossRefGoogle Scholar
  70. 70.
    Lu X-J, Deb S, Soares MJ (1994) Spontaneous differentiation of trophoblast cells along the spon-giotrophoblast pathway: expression of the placental prolactin gene family and modulation by retinoic acid. Dev Biol 163:86–97.PubMedCrossRefGoogle Scholar
  71. 71.
    Robertson MC, Cosby H, Shiu RPC (1996) Rat placental lactogen-I variant (rPL-Iv), product of an unique gene, is biologically different from rPL-I. Endocrinology 137:5242–5249.PubMedCrossRefGoogle Scholar
  72. 72.
    Colosi P, Marr G, Lopez J, Haro L, Ogren L, Talamantes F (1982) Isolation, purification, and characterization of mouse placental lactogen. Proc Natl Acad Sci USA 79:771–775.PubMedCrossRefGoogle Scholar
  73. 73.
    Duckworth ML, Kirk KL, Friesen HG (1986) Isolation and identification of a cDNA clone of rat placental lactogen II. J Biol Chem 261:10,871-10,878.Google Scholar
  74. 74.
    Kishi K, Hirashiba M, Hasegawa Y (1992) Multiple forms of rat placental lactogen-II (rPL-II): purification and partial characterization of rPL-II. Placenta 13:63–79.PubMedCrossRefGoogle Scholar
  75. 75.
    Jackson LL, Colosi P, Talamantes F, Linzer DIH (1986) Molecular cloning of mouse placental lactogen cDNA. Proc Natl Acad Sci USA 83:8496–8500.PubMedCrossRefGoogle Scholar
  76. 76.
    Robertson MC, Friesen HG (1975) The purification and characterization of rat placental lactogen. Endocrinology 97:621–629.CrossRefGoogle Scholar
  77. 77.
    Southard JN, Thordarson G, Talamantes F (1986) Purification and partial characterization of hamster placental lactogen. Endocrinology 119:508–514.PubMedCrossRefGoogle Scholar
  78. 78.
    Southard JN, Do L, Smith WC, Talamantes F (1989) Hamster placental lactogen-II contains a structural feature unique among the growth hormone-prolactin-placental lactogen family. Mol Endocrinol 3:1710–1713.PubMedCrossRefGoogle Scholar
  79. 79.
    Southard JN, Talamantes F (1987) Immunological studies of rodent placental lactogens. Mol Cell Endocrinol 50:29–36.PubMedCrossRefGoogle Scholar
  80. 80.
    Deb S, Hashizume K, Boone K, et al. (1989) Antipeptide antibodies reveal structural and functional characteristics of rat placental lactogen-II. Mol Cell Endocrinol 63:45–56.PubMedCrossRefGoogle Scholar
  81. 81.
    Soares MJ, De SK, Foster BA, Julian JA, Glasser SR (1988) Identification of multiple low mol-wt placental prolactin-like proteins produced by rat trophoblast cells. J Endocrinol 116:101–106.PubMedCrossRefGoogle Scholar
  82. 82.
    Chien Y-H, Thompson EB (1980) Genomic organization of rat prolactin and growth hormone genes. Proc Natl Acad Sci USA 77:4583–4587.PubMedCrossRefGoogle Scholar
  83. 83.
    Cooke NE, Baxter JD (1982) Structural analysis of the prolactin gene suggests a separate origin for its 5′ end (1982) Nature 297:603–606.PubMedCrossRefGoogle Scholar
  84. 84.
    Maurer RA, Erwin CR, Donelson JD (1981) Analysis of 5′ flanking sequences and intron-exon boundaries of the rat prolactin gene. J Biol Chem 256:10, 524-10,528.Google Scholar
  85. 85.
    Shida MM, Jackson-Grusby LL, Ross SR, Linzer DIH (1992) Placental-specific expression from the mouse placental lactogen II gene promoter. Proc Natl Acad Sci USA 89:3864–3868.PubMedCrossRefGoogle Scholar
  86. 86.
    Campbell WJ, Deb S, Kwok SCM, Joslin JA, Soares MJ (1989) Differential expression of placental lactogen-II and prolactin-like protein-A in the rat chorioallantoic placenta. Endocrinology 125:1565–1574.PubMedCrossRefGoogle Scholar
  87. 87.
    Duckworth ML, Schroedter IC, Friesen HG (1990) Cellular localization of rat placental lactogen II and rat prolactin-like proteins A and B by in situ hybridization. Placenta 11:143–155.PubMedCrossRefGoogle Scholar
  88. 88.
    Hall J, Talamantes F (1984) Immunocytochemical localization of mouse placental lactogen in the mouse placenta. J Histochem Cytochem 32:379–382.PubMedCrossRefGoogle Scholar
  89. 89.
    Jones MA, Renegar RH (1994) Temporal and regional expression of placental lactogen-II messenger ribonucleic acid and protein in the hamster placenta. Biol Reprod 50:581–592.PubMedCrossRefGoogle Scholar
  90. 90.
    Yamaguchi M, Ogren L, Endo H, Thordarson G, Bigsby RM, Talamantes F (1992) Production of mouse placental lactogen-I and placental lactogen-II by the same giant cell. Endocrinology 131:1595–1602.PubMedCrossRefGoogle Scholar
  91. 91.
    Yamaguchi M, Ogren L, Endo H, Soares MJ, Talamantes F (1994) Co-localization of placental lactogen-I, placental lactogen-II, and proliferin in the mouse placenta at midpregnancy. Biol Reprod 51:1188–1192.PubMedCrossRefGoogle Scholar
  92. 92.
    Soares MJ (1987) Developmental changes in the intraplacental distribution of placental lactogen and alkaline phosphatase in the rat. J Reprod Fertil 79:93–98.PubMedCrossRefGoogle Scholar
  93. 93.
    Daughad WH, Trivedi B, Kapadia M (1979) The effect of hypophysectomy on rat chorionic somatomammotropin as measured by prolactin and growth hormone radioreceptor assays: possible significance in maintenance of somatomedin generation. Endocrinology 105:210–214.CrossRefGoogle Scholar
  94. 94.
    D JR, Ogren L, Talamantes F (1986) The effect of hypophysectomy on serum placental lactogen and progesterone in the mouse. Endocrinology 119:898–903.CrossRefGoogle Scholar
  95. 95.
    Kishi K, Ogren L, Southard JN, Talamantes F (1988) Pituitary factors regulating mouse placental lactogen-II (mPL-II) secretion during the last half of pregnancy in mice. Endocrinology 122:2309–2317.PubMedCrossRefGoogle Scholar
  96. 96.
    Pinon I, Kishi K, Talamantes F (1988) The kinetics of disappearance of endogenous mouse placental lactogen-II in intact and hypophysectomized pregnant mice. Mol Cell Endocrinol 55:45–51.PubMedCrossRefGoogle Scholar
  97. 97.
    Robertson MC, Owens RE, Klindt J, Friesen HG (1984) Ovariectomy leads to a rapid increase in rat placental lactogen secretion. Endocrinology 114:1805–1811.PubMedCrossRefGoogle Scholar
  98. 98.
    Robertson MC, Owens RE, McCoshen JA, Friesen HG (1984) Ovarian factors inhibit and fetal factors stimulate the secretion of rat placental lactogen. Endocrinology 114:22–30.PubMedCrossRefGoogle Scholar
  99. 99.
    Soares MJ, Bartke A, Colosi P, Talamantes F (1984) Identification of a placental lactogen in pregnant Snell and Ames dwarf mice. Proc Soc Exp Biol Med 175:106–108.PubMedGoogle Scholar
  100. 100.
    Soares MJ, Talamantes F (1985) Placental lactogen secretion in the mouse: in vitro responses and ovarian and hormonal influences. J Exp Zool 234:97–104.PubMedCrossRefGoogle Scholar
  101. 101.
    Tonkowicz PA, Voogt JL (1984) Ovarian and fetal control of rat placental lactogen and prolactin secretion at midpregnancy. Endocrinology 114:254–259.PubMedCrossRefGoogle Scholar
  102. 102.
    Roby KF, Soares MJ (1993) Trophoblast cell differentiation and organization: role of fetal and ovarian signals. Placenta 14:529–545.PubMedCrossRefGoogle Scholar
  103. 103.
    Thordarson G, Southard JN, Talamantes F (1991) Purification and characterization of mouse decidual calcyclin: a novel stimulator of mouse placental lactogen-II secretion. Endocrinology 129:1257–1265.PubMedCrossRefGoogle Scholar
  104. 104.
    Kishi K, Itoh M, Kanamori S, Hirashiba M, Kawai M (1993) Stimulation of rat placental lactogen-II (rPL-II) secretion by cultured trophoblasts by insulin: development of a rat placental cell culture system and effects of peptide hormones on rPL-II seceretion in vitro. J Reprod Fertil 99:519–527.PubMedCrossRefGoogle Scholar
  105. 105.
    Yamaguchi M, Ogren L, Southard JN, Kurachi H, Miyake A, Talamantes F (1993) Interleukin 6 inhibits mouse placental lactogen II but not mouse placental lactogen I secretion in vitro. Proc Natl Acad Sci USA 90:11,905-11.909.CrossRefGoogle Scholar
  106. 106.
    Yamaguchi M, Kurachi H, Tadokoro C, Sakata M, Yoshimoto Y, Masumoto N, Tasaka K, Miyake A (1994) Tumor necrosis factor-alpha (TNFalpha) inhibits expression of mouse placental lactogen-II through TNF alpha type-I but not type-II receptor. Biochem Biophys Res Commun 202:1599–1605.PubMedCrossRefGoogle Scholar
  107. 107.
    Yamaguchi M, Ogren L, Barnard R, Imai T, Sawada T, Miyake A, Talamantes F (1994) Selective inhibition of mouse placental lactogen II secretion by tumour necrosis factor-alpha. J Endocrinol 143:95–105.PubMedCrossRefGoogle Scholar
  108. 108.
    Yamaguchi M, Maeda T, Yoneda M, Nishizaki T, Miyake A (1995) Posttranscriptional inhibition of mouse placental lactogen-II secretion by transforming growth factor betal: synergistic effects with epidermal growth factor and interleukin-6. Biol Reprod 53:373–379.PubMedCrossRefGoogle Scholar
  109. 109.
    Yamaguchi M, Tasaka K, Ogura K, Sakata M, Mizuki J, Miyake A (1995) Activin inhibits but inhibin activates mouse placental lactogen-II secretion. J Endocrinol 146:469–474.PubMedCrossRefGoogle Scholar
  110. 110.
    Yamaguchi M, Sakata M, Ogura K, Adachi K, Mammoto A, Miyake A (1996) Inhibition of mouse placental lactogen-II release from placental cells by interleukin-1 after mid-pregnancy. J Endocrinol 147:423–429.CrossRefGoogle Scholar
  111. 111.
    Yamaguchi M, Sawada K, Miyake A (1996) Lipopolysaccharides selectively inhibit mouse placental lactogen-II secretion through stimulation of interleukin-lα (IL-lα) and IL-6 production. J Endocrinol Invest 19:415–421.PubMedGoogle Scholar
  112. 112.
    Shida M, Ng Y-K, Linzer DIH (1993) Transcriptional regulation of the placental lactogen genes in mouse trophoblast giant cells, In: Trophoblast Cells. Pathways for maternal-Embryonic Communication (Soares MJ, Handwerger S, Talamantes F, eds.), Springer-Verlag, New York, pp. 243–252.Google Scholar
  113. 113.
    Vuille J-C, Cattini PA, Bock ME, Verstuyf A, Schroedter IC, Duckworth ML, Friesen HG (1993) Rat prolactin-like protein-A partial gene and promoter structure: promoter activity in placental and pituitary cells. Mol Cell Endocrinol 96:91–98.PubMedCrossRefGoogle Scholar
  114. 114.
    Southard JN, Talamantes F (1989) High mol-wt forms of placental lactogen: evidence for lactogen-macroglobulin complexes in rodents and humans. Endocrinology 125:791–800.PubMedCrossRefGoogle Scholar
  115. 115.
    Harigaya T, Smith WC, Talamantes F (1988) Hepatic placental lactogen receptors during pregnancy in the mouse. Endocrinology 122:1366–1372.PubMedCrossRefGoogle Scholar
  116. 116.
    Thordarson G, Villalobos R, Colosi P, Southard J, Ogren L, Talamantes F (1986) Lactogenic response of cultured mouse mammary epithelial cells to mouse placental lactogen. J Endocrinol 109:263–274.PubMedCrossRefGoogle Scholar
  117. 117.
    Kawai M, Kishi K (1997) In vitro studies on the stimulation of insulin secretion and B cell proliferation by rat placental lactogen II during pregnancy in rats. J Reprod Fertil 109:145–152.PubMedCrossRefGoogle Scholar
  118. 118.
    Davis JA, Linzer DIH (1989) A mutant lactogenic hormone binds, but does not activate, the prolactin receptor. Mol Endocrinol 3:949–953.PubMedCrossRefGoogle Scholar
  119. 119.
    Davis JA, Linzer DIH (1989) Mutational analysis of a lactogenic hormone reveals a role for lactogen-specific amino acid residues in receptor binding and mitogenic activity. Mol Endocrinol 3:1987–1995.PubMedCrossRefGoogle Scholar
  120. 120.
    Duckworth ML, Peden LM, Friesen HG (1986) Isolation of a novel prolactin-like cDNA clone from developing rat placenta. J Biol Chem 261:10,879-10,884.Google Scholar
  121. 121.
    Deb S, Youngblood T, Rawitch AB, Soares MJ (1989) Placental prolactin-like protein A. Identification and characterization of two major glycoprotein species with antipeptide antibodies. J Biol Chem 264:14,348-14,353.Google Scholar
  122. 122.
    Manzella SM, Dharmesh SM, Cohick CB, Soares MJ, Baenziger JU (1997) Developmental regulation of a pregnancy-specific oligosaccharide structure, NeuAcβ2,6GalNAcβ1,4GlcNAc on select members of the rat placental prolactin family. J Biol Chem 272:4775–4782.PubMedCrossRefGoogle Scholar
  123. 123.
    Deb S, Soares MJ (1990) Characterization of placental prolactin-like protein-A in intracellular and extracellular compartments. Mol Cell Endocrinol 74:163–172.PubMedCrossRefGoogle Scholar
  124. 124.
    Deb S, Hamlin GP, Roby KF, Kwok SCM, Soares MJ (1993) Heterologous expression and characterization of prolactin-like protein-A. Identification of serum binding proteins. J Biol Chem 268:3298–3305.PubMedGoogle Scholar
  125. 125.
    Duckworth ML, Peden LM, Friesen HG (1988) A third prolactin-like protein expressed by the developing rat placenta: complementary deoxyribonucleic acid sequence and partial structure of the gene. Mol Endocrinol 2:912–920.PubMedCrossRefGoogle Scholar
  126. 126.
    Cohick CB, Xu L, Soares MJ (1997) Prolactin-like protein-B: heterologous expression and characterization of placental and decidual species. J Endocrinol 152:291–302.PubMedCrossRefGoogle Scholar
  127. 127.
    Croze F, Kennedy TG, Schroedter IC, Friesen HG (1990) Expression of rat prolactin-like protein B in deciduoma of pseudopregnant rat and in decidua during early pregnancy. Endocrinology 127:2665–2672.PubMedCrossRefGoogle Scholar
  128. 128.
    Ogilvie S, Duckworth ML, Larkin LH, Buhi WC, Shiverick KT (1990) De novo synthesis and secretion of prolactin-like protein-B by rat placental expiants. Endocrinology 126:2561–2566.PubMedCrossRefGoogle Scholar
  129. 129.
    Faria TN, Deb S, Vandeputte M, Talamantes F, Soares MJ (1990) Transplantable rat choriocarcinoma cells express placental lactogen: identification of placental lactogen-I immunoreactive protein and messenger ribonucleic acid. Endocrinology 127:3131–3137.PubMedCrossRefGoogle Scholar
  130. 130.
    Gibori G, Jayatilak PG, Khan I, Rigby B, Puryear T, Nelson S, Herz Z (1987) Decidual luteotropin secretion and action: its role in pregnancy maintenance in the rat, In: Regulation of Ovarian and Testicular function (Mahesh VB, Dhindsa DS, Anderson E, Kalra SP, eds.), Plenum, New York, pp. 379–397.CrossRefGoogle Scholar
  131. 131.
    Ogilvie S, Buhi WC, Olson JA, Shiverick KT (1990) Identification of a novel family of growth hormone-related proteins secreted by rat placenta. Endocrinology 126:3271–3273.PubMedCrossRefGoogle Scholar
  132. 132.
    Deb S, Roby KF, Faria TN, Larsen D, Soares MJ (1991) Identification and immunochemical characterization of a major placental secretory protein related to the prolactin-growth hormone family, prolactin-like protein-C. Endocrinology 128:3066–3072.PubMedCrossRefGoogle Scholar
  133. 133.
    Deb S, Roby KF, Faria TN, Szpirer C, Levan G, Kwok SCM, Soares MJ (1991) Molecular cloning and characterization of prolactin-like protein-C complementary deoxyribonucleic acid. J Biol Chem 266:23,027-23,032.Google Scholar
  134. 134.
    Dai G, Liu B, Szpirer C, Levan G, Kwok SCM, Soares MJ (1996) Prolactin-like protein-C variant: complementary DNA, unique six exon gene structure, and trophoblast cell-specific expression. Endocrinology 137:5009–5019.PubMedCrossRefGoogle Scholar
  135. 135.
    Conliffe PR, Simmen RCM, Buhi WC, Shiverick KT (1995) Cloning of a novel rat placental prolactin-like protein C-related cDNA. Mol Reprod Dev 41:167–176.PubMedCrossRefGoogle Scholar
  136. 136.
    Linzer DIH, Nathans D (1985) A new member of the prolactin-growth hormone gene family expressed in mouse placenta. EMBO J 4:1419–1423.PubMedGoogle Scholar
  137. 137.
    Iwatsuki K, Shinozaki M, Hattori N, Hirasawa K, Itagaki S-I, Shiota K, Ogawa T (1996) Molecular cloning and characterization of a new member of the rat placental prolactin (PRL) family PRL-like protein D (PLP-D). Endocrinology 137:3849–3855.PubMedCrossRefGoogle Scholar
  138. 138.
    Roby KF, Deb S, Gibori G, Szpirer C, Levan G, Kwok SCM, Soares MJ (1993) Decidual prolactin-related protein. Identification, molecular cloning, and characterization. J Biol Chem 268:3136–3142.PubMedGoogle Scholar
  139. 139.
    Conliffe PR, Farmerie WG, Charles GD, Buhi WC, Kelly PA, Simmen RCM, Shiverick KT (1994) Expression and characterization of recombinant rat placental prolactin-like protein C. Mol Cell Endocrinol 106:121–130.PubMedCrossRefGoogle Scholar
  140. 140.
    Rasmussen CA, Orwig KE, Vellucci S, Soares MJ (1997) Dual expression of prolactin-related protein in decidua and trophoblast tissues during pregnancy. Biol Reprod 56:647–654.PubMedCrossRefGoogle Scholar
  141. 141.
    Orwig KE, Dai G, Rasmussen CA, Soares MJ (1997) Decidual prolactin-related protein: characterization of gene structure and cell-specific expression. Endocrinology 138:2491–2500.PubMedCrossRefGoogle Scholar
  142. 142.
    Gu Y, Soares MJ, Srivastava RK, Gibori G (1994) Expression of decidual prolactin-related protein in the rat decidua. Endocrinology 135:1422–1427.PubMedCrossRefGoogle Scholar
  143. 143.
    Rasmussen CA, Hashizume K, Orwig KE, Vellucci S, Xu L, Soares MJ (1996) Decidual prolactin-related protein: heterologous expression and characterization. Endocrinology 137:5558–5566.PubMedCrossRefGoogle Scholar
  144. 144.
    Laurie GW (1985) Lack of heparan sulfate proteoglycan in a discontinuous and irregular placental basement membrane. Dev Biol 108:299–309.PubMedCrossRefGoogle Scholar
  145. 145.
    Linzer DIH, Lee S-J, Ogren L, Talamantes F, Nathans D (1985) Identification of proliferin mRNA and protein in mouse placenta. Proc Natl Acad Sci USA 82:4356–4359.PubMedCrossRefGoogle Scholar
  146. 146.
    Nilsen-Hamilton M, Shapiro JM, Massoglia SL, Hamilton RT (1980) Selective stimulation by mitogens of incorporation of 35S-methionine into a family of proteins released into the medium by 3T3 cells. Cell 20:19–28.PubMedCrossRefGoogle Scholar
  147. 147.
    Nilsen-Hamilton M, Hamilton RT, Alvarez-Azaustre E (1987) Relationship between mitogen-regulated protein (MRP) and proliferin (PLF), a member of the prolactin/growth hormone family. Gene 51:163–170.PubMedCrossRefGoogle Scholar
  148. 148.
    Linzer DIH, Nathans D (1983) Growth-related changes in specific mRNAs of cultured mouse cells. Proc Natl Acad Sci USA 80:4271–4275.PubMedCrossRefGoogle Scholar
  149. 149.
    Linzer DIH, Nathans D (1984) Nucleotide sequence of a growth-related mRNA encoding a member of the prolactin-growth hormone family. Proc Natl Acad Sci USA 81:4255–4259.PubMedCrossRefGoogle Scholar
  150. 150.
    Parfett CL, Hamilton RT, Howell BW, Edwards DR, Nilsen-Hamilton M, Denhardt DT (1985) Characterization of a cDNA clone encoding murine mitogen-regulated protein: regulation of mRNA levels in mortal and immortal cell lines. Mol Cell Biol 5:3289–3292.PubMedGoogle Scholar
  151. 151.
    Wilder EL, Linzer DIH (1986) Expression of multiple proliferin genes in mouse cells. Mol Cell Biol 6:3283–3286.PubMedGoogle Scholar
  152. 152.
    Connor AM, Waterhouse P, Khokha R, Denhardt DT (1989) Characterization of a mouse mitogen-regulated protein/proliferin gene and its promoter: a member of the growth hormone/ prolactin gene superfamily. Biochim Biophys Acta 1009:75–82.PubMedCrossRefGoogle Scholar
  153. 153.
    Lee S-J, Nathans D (1987) Secretion of proliferin. Endocrinology 120:208–213.PubMedCrossRefGoogle Scholar
  154. 154.
    Colosi P, Swiergiel JJ, Wilder EL, Oviedo A, Linzer DIH (1988) Characterization of proliferin-related protein. Mol Endocrinol 2:579–586.PubMedCrossRefGoogle Scholar
  155. 155.
    Lee S-J, Talamantes F, Wilder E, Linzer DIH, Nathans D (1988) Trophoblastic giant cells of the mouse placenta as the site of proliferin synthesis. Endocrinology 122:1761–1768.PubMedCrossRefGoogle Scholar
  156. 156.
    Nilsen-Hamilton M, Jang YJ, Alvarez-Azaustre E, Hamilton RT (1988) Regulation of the production of a prolactin-like protein (MRP/PLF) in 3T3 cells and in the mouse placenta. Mol Cell Endocrinol 56:179–190.PubMedCrossRefGoogle Scholar
  157. 157.
    Yamaguchi M, Imai T, Maeda T, Sakata M, Miyake A, Linzer DIH (1995) Cyclic adenosine 3′,5″ monophosphate stimulation of placental proliferin and proliferin-related protein secretion. Endocrinology 136:2040–2046.PubMedCrossRefGoogle Scholar
  158. 158.
    Linzer DIH, Wilder EL (1987) Control of proliferin gene expression in serum-stimulated mouse cells. Mol Cell Biol 7:2080–2086.PubMedGoogle Scholar
  159. 159.
    Linzer DIH, Mordacq JC (1987) Transcriptional regulation of proliferin gene expression in response to serum in transfected mouse cells. EMBO J 6:2281–2288.PubMedGoogle Scholar
  160. 160.
    Nilsen-Hamilton M, Jang YJ, Delgado M, Shim JK, Bruns K, Chiang CP, Fang Y, Parfett CL, Denhardt DT, Hamilton RT (1991) Regulation of the expression of mitogen-regulated protein (MRP; proliferin) and cathepsin L in cultured cells and in the murine placenta. Mol Cell Endocrinol 77:115–122.PubMedCrossRefGoogle Scholar
  161. 161.
    Mordacq JC, Linzer DIH (1989) Co-localization of elements required for phorbol ester stimulation and glucocorticoid repression of proliferin gene expression. Genes Dev 3:760–769.PubMedCrossRefGoogle Scholar
  162. 162.
    Groskopf JC, Linzer DIH (1994) Characterization of a delayed early serum response region. Mol Cell Biol 14:6013–6020.PubMedCrossRefGoogle Scholar
  163. 163.
    Parfett CLJ (1992) Induction of proliferin gene expression by diverse chemical agents that promote morphological transformation in C3H/10T1/2 cultures. Cancer Lett 64:1–9.PubMedCrossRefGoogle Scholar
  164. 164.
    Parfett CL, Pilon R (1993) Tri-n-butyltin chloride promotes morphological transformation and induces proliferin expression in C3H10T1/2 cells. Cancer Lett 71:167–176.PubMedCrossRefGoogle Scholar
  165. 165.
    Parfett CL, Pilon R (1995) Oxidative stress-regulated gene expression and promotion of morphological transformation induced in C3H/10T1/2 cells by ammonium metavanadate. Food Chem Toxicol 33:301–308.PubMedCrossRefGoogle Scholar
  166. 166.
    Edwards DR, Parfett CL, Smith JH, Denhardt DT (1987) Evidence that post-transcriptional changes in the expression of mitogen regulated protein accompany immortalization of mouse cells. Biochem Biophys Res Commun 147:467–473.PubMedCrossRefGoogle Scholar
  167. 167.
    Malyankar UM, Rittling SR, Connor A, Denhardt DT (1994) The mitogen-regulated protein/ proliferin transcript is degraded in primary mouse embryo fibroblast but not 3T3 nuclei: altered RNA processing correlates with immortalization. Proc Natl Acad Sci USA 91:335–339.PubMedCrossRefGoogle Scholar
  168. 168.
    Malyankar UM, Rittling SR, Denhardt DT (1996) Instability of endogenous MRP/proliferin transcripts in the nucleus of mouse embryo fibroblasts contrasts with their stability when produced during transient transfections. J Cell Biochem 60:198–210.PubMedCrossRefGoogle Scholar
  169. 169.
    Jackson D, Linzer DIH (1997) Proliferin transport and binding in the mouse fetus. Endocrinology 138:149–155.PubMedCrossRefGoogle Scholar
  170. 170.
    Jackson D, Volpert OV, Bouck N, Linzer DIH (1994) Stimulation and inhibition of angiogenesis by placental proliferin and proliferin-related protein. Science 266:1581–1584.PubMedCrossRefGoogle Scholar
  171. 171.
    Clapp C, Weiner RI (1992) A specific, high affinity, saturable binding site for the 16-kilodalton fragment of prolactin on capillary endothelial cells. Endocrinology 130:1380–1386.PubMedCrossRefGoogle Scholar
  172. 172.
    Volpert O, Jackson D, Bouck N, Linzer DIH (1996) The insulin-like growth factor II/mannose 6-phosphate receptor is required for proliferin-induced angiogenesis. Endocrinology 137:3871–3876.PubMedCrossRefGoogle Scholar
  173. 173.
    Lee S-J, Nathans D (1988) Proliferin secreted by cultured cells binds to mannose 6-phosphate receptors. J Biol Chem 263:3521–3527.PubMedGoogle Scholar
  174. 174.
    Rogers SA, Purchio AF, Hammerman MR (1990) Mannose 6-phosphate-containing peptides activate phospholipase C in proximal tubular basolateral membranes from canine kidney. J Biol Chem 265:9722–9727.PubMedGoogle Scholar
  175. 175.
    Nelson JT, Rosenzweig N, Nilsen-Hamilton M (1995) Characterization of the mitogen-regulated protein (proliferin) receptor. Endocrinology 136:283–288.PubMedCrossRefGoogle Scholar
  176. 176.
    Muscat GE, Gobius K, Emery J (1991) Proliferin, a prolactin/growth hormone-like peptide represses myogenic-specific transcription by the suppression of an essential serum response factor-like DNA-binding activity. Mol Endocrinol 5:802–814.PubMedCrossRefGoogle Scholar
  177. 177.
    Wilder EL, Linzer DIH (1989) Participation of multiple factors, including proliferin, in the inhibition of myogenic differentiation. Mol Cell Biol 9:430–441.PubMedGoogle Scholar
  178. 178.
    Barnes SW, Renegar RH (1996) Identification, characterization, and expression of a new prolactin-like molecule in the hamster placenta. Biol Reprod 55:370–378.PubMedCrossRefGoogle Scholar
  179. 179.
    Cooke NE, Szpirer C, Levan G (1986) The related genes encoding growth hormone and prolactin have been dispersed to chromosomes 10 and 17 in the rat. Endocrinology 119:2451–2454.PubMedCrossRefGoogle Scholar
  180. 180.
    Jackson-Grusby LL, Pravtcheva D, Ruddle FH, Linzer DIH (1988) Chromosomal mapping of the prolactin/growth hormone gene family in the mouse. Endocrinology 122:2462–2466.PubMedCrossRefGoogle Scholar
  181. 181.
    Owerbach D, Rutter WJ, Cooke NE, Martial JA, Shows TB (1981) The prolactin gene is located on chromosome 6 in humans. Science 212:815,816.PubMedCrossRefGoogle Scholar
  182. 182.
    Schuler LA, Scott P, Kessler MA (1993) Molecular genetics and biology of the bovine placental prolactin family, In: Trophoblast Cells. Pathways for Maternal-Embryonic Communication (Soares MJ, Handwerger S, Talamantes F, eds.), Springer-Verlag, New York, pp. 191–205.Google Scholar
  183. 183.
    Cooke NE, Jones BK, Urbanek M, Misra-Press A, Lee AK, Russell JE, MacLeod JN, Liebhaber SA (1993) Placental expression and function of the human growth hormone gene cluster, In: Trophoblast Cells. Pathways for Maternal-Embryonic Communication (Soares MJ, Handwerger S, Talamantes F, eds.), Springer-Verlag, New York, pp. 222–239.Google Scholar
  184. 184.
    Goffin V, Shiverick KT, Kelly PA, Martial JA (1996) Sequence-function relationships within the expanding family of prolactin, growth hormone, placental lactogen, and related proteins in mammals. Endocr Rev 17:385–410.PubMedGoogle Scholar
  185. 185.
    Erskine MS (1995) Prolactin release after mating and genitosensory stimulation in females. Endocr Rev 16:508–528.PubMedGoogle Scholar
  186. 186.
    Gunnet JW, Freeman ME (1983) The mating-induced release of prolactin: a unique neuroendocrine response. Endocr Rev 4:44–61.PubMedCrossRefGoogle Scholar
  187. 187.
    Neill JD (1980) Neuroendocrine regulation of prolactin secretion. Frontiers Neuroendocrinol 6:129–155.Google Scholar
  188. 188.
    Morishige W, Rothchild I (1974) Temporal aspects of the regulation of corpus luteum function by luteinzing hormone, prolactin, and placental luteotrophin during the first half of pregnancy in the rat. Endocrinology 95:260–272.PubMedCrossRefGoogle Scholar
  189. 189.
    Guillemot F, Nagy A, Auerbach A, Rossant J, Joyner A (1994) Essential role of Mash-2 in extraembryonic development. Nature 371:333–336.PubMedCrossRefGoogle Scholar
  190. 190.
    Guillemot F, Caspary T, Tilghman SM, Copeland, NG, Gilbert DJ, Jenkins NA, Anderson DJ, Joyner AL, Rossant J, Nagy A (1995) Genomic imprinting of Mash2, a mouse gene required for trophoblast development. Nature Genetics 9:235–241.PubMedCrossRefGoogle Scholar
  191. 191.
    Sibilia M, Wagner EF (1995) Strain-dependent epithelial defects in mice lacking the EGF receptor. Science 269:234–238.PubMedCrossRefGoogle Scholar
  192. 192.
    Threadgill DW, Dlugosz AA, Hansen J, Tennenbaum T, Lichti U, Yee D, LaMantia C, Mourton T, Herrup K, Harris RC, Barnard JA, Yuspa SH, Coffey RJ, Magnuson T (1995) Targeted disruption of mouse EGF receptor: effect of genetic background on phenotype. Science 269:230–234.PubMedCrossRefGoogle Scholar
  193. 193.
    Royster M, Driscoll P, Kelly PA, Freemark M (1995) The prolactin receptor in the fetal rat: cellular localization of messenger ribonucleic acid, immunoreactive protein, and ligand-binding activity and induction of expression in late gestation. Endocrinology 136:3892–3900.PubMedCrossRefGoogle Scholar
  194. 194.
    Ormandy CJ, Binart N, Camus A, Barra J, Damotte D, Lucas B, Buteau H, Edery M, Brousse N, Babinet C, Binart N, Kelly PA (1997) Null mutation of the prolactin receptor gene produces multiple reproductive defects in the mouse. Genes Dev 11:167–178.PubMedCrossRefGoogle Scholar
  195. 195.
    Bridges RS, Goldman BD (1975) Ovarian control of prolactin secretion during late pregnancy in the rat. Endocrinology 97:496–498.PubMedCrossRefGoogle Scholar
  196. 196.
    Chatelain A, Dupuoy JP, Dubois MP (1979) Ontogenesis of cells producing polypeptide hormones (ACTH, MSH, LPH, GH, Prolactin) in the fetal hypophysis of the rat: influence of the hypothalamus. Cell Tissue Res 196:409–427.PubMedCrossRefGoogle Scholar
  197. 197.
    Grattan D, Averill RLW (1990) Effect of ovarian steroids on a nocturnal surge of prolactin secretion that precedes parturition in the rat. Endocrinology 126:1119–1205.CrossRefGoogle Scholar
  198. 198.
    Simmons DM, Voss JW, Ingraham HA, Holloway JM, Broide RS, Rosenfeld MG, Swanson LW (1990) Pituitary cell phenotypes involve cell-specific Pit-1 mRNA translation and synergistic interactions with other classes of transcription factors. Genes Dev 4:695–711.PubMedCrossRefGoogle Scholar
  199. 199.
    Tong Y, Zhao H, Labrie F, Pelletier G (1989) Ontogeny of prolactin mRNA in the rat pituitary gland as evaluated by in situ hybridization. Mol Cell Endocrinol 67:11–16.PubMedCrossRefGoogle Scholar
  200. 200.
    Watanabe YG, Daikoku S (1979) An immunohistochemical study of the cytogenesis of adenohypophysial cells in fetal rats. Dev Biol 68:557–567.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Michael J. Soares
  • Guoli Dai
  • Christopher B. Cohick
  • Heiner Müller
  • Kyle E. Orwig

There are no affiliations available

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