Compatibility Testing for Red Blood Cell Components: Approaches and Limitations

  • Kathleen Sazama
Chapter
Part of the Contemporary Hematology book series (CH)

Abstract

Compatibility testing for red blood cell transfusion in U.S. health care facilities consists of a specified series of steps, defined in the American Association of Blood Banks’ (AABB’s) Standards for Blood Banks and Transfusion Services (Standards) (1) and further described in the AABB’s Technical Manual (2). The elements of this process include assuring that a physician order exists and that a proper request has occurred, obtaining or receiving a properly collected and labeled patient sample, testing the patient sample for ABO and Rh, performing a historical check of prior patient ABO, testing of donor unit for ABO (and D, if D-negative), screening patient serum for unexpected antibodies, identifying any unexpected antibodies, and performing a crossmatch between donor cells and patient serum (or an electronic cross-match if specific conditions are met). At every step in this process, choices occur (Fig. 1). To ensure that all appropriate actions occur, a checklist is helpful. Table 1 is an example of a checklist based in part on the AABB’s Quality Program, System I: Compatibility Testing (3).

Keywords

EDTA Transportation Assure Diamine Allo 

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References

  1. 1.
    Klein HG, ed. Standards for Blood Banks and Transfusion Services, 17th ed. Bethesda, MD: American Association of Blood Banks, 1996.Google Scholar
  2. 2.
    Fuller R, ed. Technical Manual, 11th ed. Bethesda, MD: American Association of Blood Banks, 1996.Google Scholar
  3. 3.
    AABB’s Quality Program, vols. 1 & 2, Bethesda, MD: American Association of Blood Banks, 1995.Google Scholar
  4. 4.
    Title 21, Code of Federal Regulations, Part 606, U. S. Government Printing Office, Washington, D.C., April 1, 1996, and FDA Guideline for Use of Equivalent Procedures for Blood Banks, Bethesda, MD, 1984.Google Scholar
  5. 5.
    Harmening DM, Firestone D. The ABO blood group system. In: Harmening DM, ed. Modern Blood Banking and Transfusion Practices, 3rd ed. Philadelphia: F. A. Davis Co., 1994, pp. 102,103.Google Scholar

Suggested Reading

  1. Harmening DM, ed. Modern Blood Banking and Transfusion Practices, 3rd ed. Philadelphia: F. A. Davis Co., 1994.Google Scholar
  2. Mallory D, ed. Immunohematology Methods and Procedures, 1st ed. Rockville, MD: American Red Cross, 1993.Google Scholar
  3. Rudmann SV, ed. Textbook of Blood Banking and Transfusion Medicine, Philadelphia, Saunders, 1995.Google Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Kathleen Sazama

There are no affiliations available

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