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Chromatin and Steroid-Receptor-Mediated Transcription

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Molecular Biology of Steroid and Nuclear Hormone Receptors

Part of the book series: Progress in Gene Expression ((PRGE))

Abstract

The normal growth and development of multicellular organisms requires precise spatial and temporal regulation of gene expression. For a subset of genes, steroid and nuclear hormone receptors act to modulate gene transcription by binding to hormone-responsive elements (HREs), usually present within the 5’-flanking region of the gene. Within the eukaryotic nucleus these regulatory DNA elements are associated with histone and nonhistone proteins to form chromatin. Consequently, a thorough mechanistic understanding of receptor-mediated transcription must reflect the fact that receptors, in concert with other transcription factors, act on genes highly organized as chromatin.

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Authors
  1. Catherine E. Watson
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  2. Trevor K. Archer
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Editors and Affiliations

  1. Cell Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 10021, New York, NY, USA

    Leonard P. Freedman

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Watson, C.E., Archer, T.K. (1998). Chromatin and Steroid-Receptor-Mediated Transcription. In: Freedman, L.P. (eds) Molecular Biology of Steroid and Nuclear Hormone Receptors. Progress in Gene Expression. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1764-0_8

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  • DOI: https://doi.org/10.1007/978-1-4612-1764-0_8

  • Publisher Name: Birkhäuser, Boston, MA

  • Print ISBN: 978-1-4612-7271-7

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