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Transcriptional Cross-Talk by Steroid Hormone Receptors

  • Chapter
Molecular Biology of Steroid and Nuclear Hormone Receptors

Part of the book series: Progress in Gene Expression ((PRGE))

Abstract

In the enormous signal flow between the cell’s environment and the nucleus, mechanisms must exist that integrate the fluxes, which balance out opposing influences and permit an ordered realization of a genetic program. In addition, any stimulus inducing signaling to the nucleus must subsequently be “turned off” or limited by a negative control step. These goals of integration and control can be achieved on many levels: (1) at the cell surface (e.g., growth factor receptor antagonists: Hannum et al 1990, Schweitzer et al 1995), (2) during signal transduction (e.g., PKC inhibits the EGF receptor: King and Cooper 1986, Lin et al 1986; proline-directed protein kinase activation is mostly transient and obviously subject to negative regulation), and (3) ultimately in the nucleus, where incoming signals are converted into gene expression. The cross-talk between transcription factors to be covered here represents an example of this latter class.

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  1. Peter Herrlich
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  2. Martin Göttlicher
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  1. Cell Biology and Genetics, Memorial Sloan-Kettering Cancer Center, 10021, New York, NY, USA

    Leonard P. Freedman

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Herrlich, P., Göttlicher, M. (1998). Transcriptional Cross-Talk by Steroid Hormone Receptors. In: Freedman, L.P. (eds) Molecular Biology of Steroid and Nuclear Hormone Receptors. Progress in Gene Expression. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1764-0_7

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