Interpretation of Coronary Vascular Perfusion

  • H. Frederick Frasch
  • J. Yasha Kresh
  • Abraham Noordergraaf


Despite years of innovative experimentation and the development of numerous models of the coronary circulation, controversy remains over the fundamental mechanisms underlying coronary vascular perfusion. The fundamental reason for this is the inaccessibility of the intramyocardial vessels to direct measurement. The coronary circulation is thus a prime candidate for physiological modeling.


Left Ventricular Pressure Vessel Segment Coronary Circulation Transmural Pressure Diastolic Interval 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Borg TK, Caulfield JB. The collagen matrix of the heart. Federation Proc. 1981;40:2037–2041.Google Scholar
  2. 2.
    Bouma P. Coronary blood flow and contraction. Amsterdam: Free University of Amsterdam; 1991. Dissertation.Google Scholar
  3. 3.
    Downey JM, Kirk ES. Inhibition of coronary blood flow by a vascular waterfall mechanism. Circ Res. 1975;36:753–760.PubMedCrossRefGoogle Scholar
  4. 4.
    Flynn AE, Coggins DL, Goto M, Aldea GS, Austin RE, Doucette JW, Husseini W, Hoffman JIE. Does systolic subepicardial perfusion come from retrograde subendocardial flow? Am J Physiol. 1992;262:H1759–H1769.PubMedGoogle Scholar
  5. 5.
    Frasch HF. Interpretation of coronary circulatory perfusion. Philadelphia: University of Pennsylvania, 1993 (University Microfilms International No. 9413831). Dissertation.Google Scholar
  6. 6.
    Frasch HF, Kresh JY, Noordergraaf A. Wave transmission and input impedance of a model of skeletal muscle microvasculature. Ann Biomed Eng. 1994; 22:45–57.PubMedCrossRefGoogle Scholar
  7. 7.
    Frasch HF, Kresh JY, Noordergraaf A. Two-port analysis of microcirculation: An extension of Windkessel. Am J Physiol. 1996;270:H376–H385.PubMedGoogle Scholar
  8. 8.
    Fung YC. Biomechanics: Mechanical Properties of Living Tissues. New York: Springer-Verlag; 1981.Google Scholar
  9. 9.
    Hanley FL, Messina LM, Gratten MT, Hoffman JIE. The effect of coronary inflow pressure on coronary vascular resistance in the isolated dog heart. Circ Res. 1984;54:760–772.PubMedCrossRefGoogle Scholar
  10. 10.
    Hoffman JIE, Spaan JAE. Pressure-flow relations in coronary circulation. Physiol Rev. 1990;70:331–390.PubMedGoogle Scholar
  11. 11.
    Izrailtyan I, Frasch HF, Kresh JY. Effects of venous pressure on coronary circulation and intramyocardial fluid mechanics. Am J Physiol. 1994;267: H1002–H1009.PubMedGoogle Scholar
  12. 12.
    Kajiya F, Tsujioka K, Goto M, Wada Y, Chen X-L, Nakai M, Tadaoka S, Hiramatsu O, Ogasawara Y, Mito K, Tomonaga G. Functional characteristics of intramyocardial capacitance vessels during diastole in the dog. Circ Res. 1986;58:476–485.PubMedCrossRefGoogle Scholar
  13. 13.
    Kassab GS. Morphometry of the coronary vasculature in the pig. La Jolla: University of California, San Diego; 1990. Dissertation.Google Scholar
  14. 14.
    Katz SA, Feigl EO. Systole has little effect on diastolic coronary artery blood flow. Circ Res. 1988;62:443–451.PubMedCrossRefGoogle Scholar
  15. 15.
    Kresh JY. Intramyocardial mechanical states: Vessel-interstitium-muscle interface. In: Sideman S, Beyar R, eds. Interactive Phenomena in the Cardiac System. New York: Plenum; 1994, Chap. 12.Google Scholar
  16. 16.
    Olsson RA, Bugni WJ. Coronary circulation. In: Fozzard HA, ed. The Heart and Cardiovascular System. New York: Raven Press; 1986:987–1037.Google Scholar
  17. 17.
    Rabbany SY, Kresh JY, Noordergraaf A. Intramyocardial pressure: Interaction of myocardial fluid pressure and fiber stress. Am J Physiol. 1989;257:H357–H364.PubMedGoogle Scholar
  18. 18.
    Spaan JAE. Coronary blood flow: Mechanics, distribution, and control. Dordrecht: Kluwer; 1991.CrossRefGoogle Scholar
  19. 19.
    Tomoike H, Ootsubo H, Sakai K, Kikuchi T, Nakamura M. Continuous measurement of coronary artery diameter in situ. Am J Physiol. 1981;240:H73–H79.PubMedGoogle Scholar
  20. 20.
    Wüsten B, Buss DD, Deist H, Schaper W. Dilatory capacity of the coronary circulation and its correlation to the arterial vasculature in the canine left ventricle. Basic Res Cardiol. 1977;72:636–650.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • H. Frederick Frasch
  • J. Yasha Kresh
  • Abraham Noordergraaf

There are no affiliations available

Personalised recommendations