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Liver Cancer pp 117-135 | Cite as

Diagnosis and Treatment of Primary Gallbladder Cancer

  • Steven A. Curley
Part of the M.D. Anderson Solid Tumor Oncology Series book series (MDA)

Abstract

Adenocarcinoma of the gallbladder is the fifth most common gastrointestinal malignancy. When compared with the worldwide incidence of hepatocellular cancer, gallbladder carcinoma accounts for fewer than 10% of the annual cases of primary hepatobiliary cancer. However, in countries such as the United States and those of western Europe with a low incidence of hepatocellular cancer, gallbladder carcinoma is relatively more prevalent. It was estimated that in the United States in 1997 there would be 6900 new cases of gallbladder cancer diagnosed compared to 12,000 cases of hepatocellular cancer.1

Keywords

Bile Duct Gallbladder Cancer Gallbladder Carcinoma Extrahepatic Bile Duct Biliary Tract Cancer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Parker SL, Tong T, Bolden S, Wingo PA. Cancer statistics, 1997. CA Cancer J Clin 47:5, 1997PubMedCrossRefGoogle Scholar
  2. 2.
    Piehler JM, Crichlow RW. Primary carcinoma of the gallbladder. Surg Gynecol Obstet 147:929, 1978PubMedGoogle Scholar
  3. 3.
    Strom BL, Soloway RD, Rios-Dalenz JL, et al. Risk factors for gallbladder cancer. Cancer 76:1747, 1995PubMedCrossRefGoogle Scholar
  4. 4.
    Nelson BD, Porvaznik J, Benfield JR. Gallbladder disease in southwestern American Indians. Arch Surg 103:41, 1971PubMedCrossRefGoogle Scholar
  5. 5.
    Rudolph R, Cohen JJ. Cancer of the gallbladder in an 11-year-old Navajo girl. J Pediatr Surg 7:66, 1972PubMedCrossRefGoogle Scholar
  6. 6.
    Mancuso TF, Brennan MJ. Epidemiological considerations of cancer of the gallbladder, bile ducts, and salivary glands in the rubber industry. J Occup Med 12:333, 1970PubMedGoogle Scholar
  7. 7.
    Enomoto M, Naoe S, Harada M, et al. Carcinogenesis in extrahepatic bile duct and gallbladder; carcinogenic effect of N-hydroxy-2-acetamidofluorene in mice fed a “gallstone-inducing” diet. Jpn J Exp Med 44:37, 1974PubMedGoogle Scholar
  8. 8.
    Nagorney DM, McPherson GAD. Carcinoma of the gallbladder and extrahepatic bile ducts. Semin Oncol 15:106, 1988PubMedGoogle Scholar
  9. 9.
    Diehl AK. Gallstone size and the risk of gallbladder cancer. JAMA 250:2323, 1983PubMedCrossRefGoogle Scholar
  10. 10.
    Polk HC. Carcinoma and the calcified gallbladder. Gastroenterology 50:582, 1966PubMedGoogle Scholar
  11. 11.
    Berk RN, Armbuster TG. Carcinoma of the porcelain gallbladder. Radiology 2:175, 1973Google Scholar
  12. 12.
    Parkash O. On the relationship of cholelithiasis to carcinoma of the gall-bladder and on the sex dependency of the carcinoma of the bile ducts. Digestion 12:129, 1975PubMedCrossRefGoogle Scholar
  13. 13.
    Ko CY, Schmit P, Cheng L, Thompson JE. Estrogen receptors in gallbladder cancer: detection by an improved immunohistochemical assay. Am Surg 61:930, 1995PubMedGoogle Scholar
  14. 14.
    Albores-Saavedra J, Alcantra-Vazquez A, Cruz-Ortiz H, et al. The precursor lesions of invasive gallbladder carcinoma: hyperplasia, atypical hyperplasia, and carcinoma in situ. Cancer 45:919, 1980PubMedCrossRefGoogle Scholar
  15. 15.
    Black WC. The morphogenesis of gallbladder carcinoma. In: Fenoglio CM, Wolff M (eds) Progress in Surgical Pathology. New York, Masson, 1980, p. 207Google Scholar
  16. 16.
    Kuzuka S, Tsubone M, Yasui A, et al. Relation of adenoma to carcinoma in the gallbladder. Cancer 50:2226, 1982CrossRefGoogle Scholar
  17. 17.
    Sumiyoshi K, Nagai E, Chijiiwa K, Nakayama F. Pathology of carcinoma of the gallbladder. World J Surg 15:315, 1991PubMedCrossRefGoogle Scholar
  18. 18.
    Fahim RB, McDonald JR, Richards JC, Ferris DO. Carcinoma of the gallbladder: a study of its modes of spread. Ann Surg 156:114, 1962PubMedCrossRefGoogle Scholar
  19. 19.
    Mishizawa-Takano J-E, Ayabe H, Hatano K, Yamaguchi H, Tagawa U. Gallbladder cancer: a comparative study among clinicopathologic features, AgNORs, and DNA content analysis. Dig Dis Sci 41:840, 1996CrossRefGoogle Scholar
  20. 20.
    Diamantis I, Karamitopoulou E, Perentes E, Zimmerman A. p53 protein immunoreactivity in extrahepatic bile duct and gallbladder cancer: correlation with tumor grade and survival. Hepatology 22:774, 1995PubMedCrossRefGoogle Scholar
  21. 21.
    Ito M, Mishima Y, Sato T. An anatomical study of the lymphatic drainage of the gallbladder. Radiol Anat 13:89, 1991CrossRefGoogle Scholar
  22. 22.
    Nevin JE, Moran TJ, Kay S, King R. Carcinoma of the gallbladder. Cancer 37:141, 1976PubMedCrossRefGoogle Scholar
  23. 23.
    Japanese Society of Biliary Surgery. The General Rules for Surgical and Pathological Studies on Cancer of Biliary Tract, 2nd ed. Tokyo, Kanehara Syuppan, 1986Google Scholar
  24. 24.
    Carmo MD, Perpetuo MO, Valdivieso M, et al. Natural history study of gallbladder cancer. Cancer 42:330, 1978CrossRefGoogle Scholar
  25. 25.
    Steinberg W. Clinical utility of the CA 19-9 tumor-associated antigen. Am J Gastroenterol 85:350, 1990PubMedGoogle Scholar
  26. 26.
    Tashiro S, Konno T, Mochinaga M, et al. Treatment of carcinoma of the gallbladder in Japan. Jpn J Surg 12:98, 1982PubMedCrossRefGoogle Scholar
  27. 27.
    Koga A, Yamauchi S, Izumi Y, et al. Ultrasonographic detection of early and curable carcinoma of the gallbladder. Br J Surg 72:728, 1985PubMedCrossRefGoogle Scholar
  28. 28.
    Wibbenmeyer LA, Sharafuddin MJA, Wolverson MK, et al. Sonographic diagnosis of unsuspected gallbladder cancer: imaging findings in comparison with benign gallbladder conditions. AJR 165:1169, 1995PubMedGoogle Scholar
  29. 29.
    Soiva M, Aro K, Pamilo M, et al. Ultrasonography in carcinoma of the gallbladder. Acta Radiol 28:711, 1987PubMedCrossRefGoogle Scholar
  30. 30.
    Palma LD, Rizzatto G, Pozzi-Mucelli RS, Bazzoccbi M. Gray-scale ultrasonography in the evaluation of the carcinoma of the gallbladder. Br J Radiol 53:662, 1980PubMedCrossRefGoogle Scholar
  31. 31.
    Itai Y, Araki T, Yoshihawa K, et al. Computed tomography of gallbladder carcinoma. Radiology 137:713, 1980PubMedGoogle Scholar
  32. 32.
    Chijiiwa K, Yumiyoshi K, Nakayama F. Impact of recent advances in hepatobiliary imaging techniques on the preoperative diagnosis of carcinoma of the gallblader. World J Surg 15:322, 1991PubMedCrossRefGoogle Scholar
  33. 33.
    Thorsen MK, Quiroz F, Lawson TL, et al. Primary biliary carcinoma: CT evaluation. Radiology 152:479, 1984PubMedGoogle Scholar
  34. 34.
    Hamrick RE, Liner J, Hastings PR, Cohn I. Primary carcinoma of the gallbladder. Ann Surg 195:270, 1982PubMedCrossRefGoogle Scholar
  35. 35.
    Klamer TW, Max MH. Carcinoma of the gallbladder. Surg Gynecol Obstet 156:641, 1983PubMedGoogle Scholar
  36. 36.
    Barr LH. Carcinoma of the gallbladder. Am Surg 50:275, 1984PubMedGoogle Scholar
  37. 37.
    Gagner M, Rossi RL. Radical operations for carcinoma of the gallbladder: present status in North America. World J Surg 15:344, 1991PubMedCrossRefGoogle Scholar
  38. 38.
    Ogura Y, Mizumoto R, Isaji S, et al. Radical operations for carcinoma of the gallbladder: present status in Japan. World J Surg 15:337, 1991PubMedCrossRefGoogle Scholar
  39. 39.
    Gall FP, Kockerling F, Scheele J, et al. Radical operations for carcinoma of the gallbladder: present status in Germany. World J Surg 15:328, 1991PubMedCrossRefGoogle Scholar
  40. 40.
    Yamaguchi K, Tsuneyoshi M. Subclinical gallbladder carcinoma. Am J Surg 163:382, 1992PubMedCrossRefGoogle Scholar
  41. 41.
    Ouchi K, Owada Y, Matsuno S, Sato T. Prognostic factors in the surgical treatment of gallbladder carcinoma. Surgery 101:731, 1987PubMedGoogle Scholar
  42. 42.
    Bergdahl L. Gallbladder carcinoma first diagnosed at microscopic examination of gallbladders removed for presumed benign disease. Ann Surg 191:19, 1980PubMedCrossRefGoogle Scholar
  43. 43.
    Donohoe JH, Nagorney DM, Grant CS, et al. Carcinoma of the gallbladder. Arch Surg 125:237, 1990CrossRefGoogle Scholar
  44. 44.
    Nimura Y, Hayakaw N, Kamiya J, et al. Hepatopancreaticoduodenectomy for advanced carcinoma of the biliary tract. Heptaogastroenterology 38:170, 1991Google Scholar
  45. 45.
    Collier NA, Blumgart LH. Tumors of the gallbladder. In: Blumgart LH (ed) Surgery of the Liver and Biliary Tract, 2nd ed. New York, Churchill Livingstone, 19–, p. 955Google Scholar
  46. 46.
    Tsukada K, Hatakeyama K, Kurosaki I, et al. Outcome of radical surgery for carcinoma of the gallbladder according to the TNM stage. Surgery 120:816, 1996PubMedCrossRefGoogle Scholar
  47. 47.
    Redaelli CA, Büchler MW, Schilling MK, et al. High coincidence of Mirizzi syndrome and gallbladder carcinoma. Surgery 121:58 1997PubMedCrossRefGoogle Scholar
  48. 48.
    Grace PA, Quereshi A, Coleman J, et al. Reduced postoperative hospitalization after laparoscopic cholecystectomy. Br J Surg 78:160, 1991PubMedCrossRefGoogle Scholar
  49. 49.
    Fong Y, Brennan MF, Turnbull A, et al. Gallbladder cancer discovered during laparoscopic surgery. Arch Surg 128:1054, 1993PubMedCrossRefGoogle Scholar
  50. 50.
    Drouard F, Delamarre J, Capron J. Cutaneous seeding of gallbladder cancer after laparoscopic cholecytectomy. N Engl J Med 325:1316, 1991PubMedGoogle Scholar
  51. 51.
    Pezet D, Fondrinier E, Rotman N, et al. Pariental seeding of carcinoma of the gallbladder after laparoscopic cholecytectomy. Br J Surg 79:230, 1992PubMedCrossRefGoogle Scholar
  52. 52.
    Kim H-J, Roy T. Unexpected gallbladder cancer with cutaneous seeding after laparoscopic cholecystectomy. South Med J 87:817, 1994PubMedCrossRefGoogle Scholar
  53. 53.
    Weiss SM, Wengery PA, Harkavy SE. Incisional recurrence of gallbladder cancer after laparoscopic cholecystectomy. Gastrointest Endosc 40:244, 1994PubMedCrossRefGoogle Scholar
  54. 54.
    Martinez J, Targarona EM, Balagué C, Peri Mi, Trias M. Port site metastasis: an unresolved problem in laparoscopic surgery. Int Surg 80:315, 1995PubMedGoogle Scholar
  55. 55.
    Clair DG, Lautz DB, Brooks DC. Rapid development of umbilical metastases after laparoscopic cholecytectomy for unsuspected gallbladder carcinoma. Surgery 113:355, 1993PubMedGoogle Scholar
  56. 56.
    Ricardo A, Feig BW, Ellis LM, et al Gallbladder cancer and trocar site recurrences: the facts regarding the myth. Am J Surg (in press)Google Scholar
  57. 57.
    Bismuth H, Castaing D, Traynor O. Resection or palliation: priority of surgery in the treatment of hilar cancer. World J Surg 12:39, 1988PubMedCrossRefGoogle Scholar
  58. 58.
    Jones RS. Palliative operative procedures for carcinoma of the gallbladder. World J Surg 15:348, 1991PubMedCrossRefGoogle Scholar
  59. 59.
    Kajanti M, Pyrhönen S. Epirubicin-sequential methotrexate-5-fluorouracil-leucovorin treatment in advanced cancer of the extrahepatic biliary system: a phase II study. Am J Clin Oncol 17:223, 1994PubMedCrossRefGoogle Scholar
  60. 60.
    Falkson G, MacIntyre JM, Moertel CG. Eastern Cooperative Oncology Group experience with chemotherapy for inoperable gallbladder and bile duct cancer. Cancer 54:965, 1984PubMedCrossRefGoogle Scholar
  61. 61.
    Hall SW, Benjamin RS, Murphy WK, et al. Adriamycin, BCNU, FTORAFUR chemotherapy of pancreatic and biliary tract cancer. Cancer 44:2008, 1979Google Scholar
  62. 62.
    Harvey JH, Smith FP, Schein PS. 5-Fluorouracil, mitomycin, and doxorubicin (FAM) in carcinoma of the biliary tract. J Clin Oncol 2:1245, 1984PubMedGoogle Scholar
  63. 63.
    Smith GW, Bukowski RM, Hewlett JS, Groppe CW. Hepatic artery infusion of 5-fluorouracil and mitomycin C in cholangiocarcinoma and gallbladder carcinoma. Cancer 54:1513, 1984PubMedCrossRefGoogle Scholar
  64. 64.
    Kairaluoma MI, Leinonen A, Niemela R, et al. Superselective intra-arterial chemotherapy with mitomycin C in liver and gallbladder cancer. Eur J Surg Oncol 14:45, 1988PubMedGoogle Scholar
  65. 65.
    Buskirk SJ, Gunderson LL, Adson MA, et al. Analysis of failure following curative irradiation of gallbladder and extrahepatic bile duct carcinoma. Int J Radiat Oncol Biol Phys 10:2013, 1984PubMedCrossRefGoogle Scholar
  66. 66.
    Smoron GL. Radiation therapy of carcinoma of gallbladder and biliary tract. Cancer 40:1422, 1977PubMedCrossRefGoogle Scholar
  67. 67.
    Pilepich MV, Lambert PM. Radiotherapy of carcinomas of the extrahepatic biliary system. Radiology 127:767, 1978PubMedGoogle Scholar
  68. 68.
    Kopelson G, Harisiadis L, Tretter P, Chang CH. The role of radiation therapy in cancer of the extra-hepatic biliary system: an analysis of thirteen patients and a review of the literature of the effectiveness of surgery, chemotherapy and radiotherapy. Int J Radiat Oncol Biol Phys 2:883, 1977PubMedCrossRefGoogle Scholar
  69. 69.
    Martenson JA, Gunderson LL, Buskirk SJ, et al. Hepatic duct stricture after radical radiation therapy for biliary cancer: recurrence or fibrosis: Mayo Clin Proc 61:530, 1986PubMedGoogle Scholar
  70. 70.
    Busse PM, Cady B, Bothe A, et al. Intraoperative radiation therapy for carcinoma of the gallbladder. World J Surg 15:352, 1991PubMedCrossRefGoogle Scholar
  71. 71.
    Todoroki T, Iwasaki Y, Okamura T, et al. Intraoperative radiotherapy for advanced carcinoma of the biliary system. Cancer 46:2179, 1980PubMedCrossRefGoogle Scholar
  72. 72.
    Morrow CE, Sutherland DER, Florack G, et al. Primary gallbladder carcinoma: significance of subserosal lesions and results of aggressive surgical treatment and adjuvant chemotherapy. Surgery 94:709, 1983PubMedGoogle Scholar
  73. 73.
    Athlin LEA, Domellof LKH, Bergman FO. Advanced gallbladder carcinoma: a case report and review of the literature. Eur J Surg Oncol 17:449, 1987Google Scholar
  74. 74.
    Kraybill WG, Lee H, Picus J, et al. Multidisciplinary treatment of biliary tract cancers. J Surg Oncol 55:239, 1994PubMedCrossRefGoogle Scholar
  75. 75.
    Todoroki T, Iwasaki Y, Orii K, et al. Resection combined with intraoperative radiation therapy (IORT) for stage IV (TNM) gallbladder carcinoma. World J Surg 15:357, 1991PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Steven A. Curley

There are no affiliations available

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