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Imaging Studies for Hepatobiliary Tumors

  • Revathy Iyer
  • Chusilp Charnsangavej
Part of the M.D. Anderson Solid Tumor Oncology Series book series (MDA)

Abstract

Surgical techniques with curative intent are becoming more common-place for both primary and metastatic tumors of the liver. The development of aggressive surgical techniques has allowed the surgeon to view a patient with a primary hepatic tumor or certain types of metastatic disease as a possible candidate for curative resection rather than as a patient with end stage disease. It is therefore important to detect and characterize hepatic lesions to determine if a patient is a surgical candidate and, if so, to plan operative strategies. It is the goal of hepatic imaging to identify and stage lesions for hepatic surgeons. The issues imaging must address include (1) whether hepatic lesions are present and, if so, how many; (2) the character of any such lesions; and (3) whether malignant tumors are resectable.1,2 These queries are now being answered more easily with advances in imaging.

Keywords

Focal Nodular Hyperplasia Cavernous Hemangioma Focal Liver Lesion Hepatic Hemangioma Hepatic Adenoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    Ferruci JT. Liver tumor imaging: current concepts. AJR 155:473, 1990Google Scholar
  2. 2.
    Sugarbaker PH. Surgical decision making for large bowel cancer metastatic to the liver. Radiology 174:621, 1990PubMedGoogle Scholar
  3. 3.
    Davis LP, McCarroll K. Correlative imaging of the liver and hepatobiliary system. Semin Nucl Med 24:208, 1994PubMedCrossRefGoogle Scholar
  4. 4.
    Rifkin ND, Rosato FE, Brauk M, et al. Intra-operative ultrasound of the liver: an important adjunctive tool for decision making in the operating room. Ann Surg 205:466, 1987PubMedCrossRefGoogle Scholar
  5. 5.
    Burns PN. Ultrasound contrast agents in radiological diagnosis. Radiologia Medica 87:71, 1994PubMedGoogle Scholar
  6. 6.
    Zemen RK, Fox SH, Silverman PM, et al. Helical (spiral) CT of the abdomen. AJR 160:719, 1993Google Scholar
  7. 7.
    Foley WD. Dynamic hepatic CT. Radiology 170:617, 1989PubMedGoogle Scholar
  8. 8.
    Matsui O, Takashima T, Kadaya M, et al. Liver metastases from colorectal cancers: detection with CT during arterial portography. Radiology 165:65, 1987PubMedGoogle Scholar
  9. 9.
    Heiken JP, Weyman PJ, Lee JKT, et al. Detection of focal hepatic masses: prospective evaluation with CT, delayed CT, CT during arterial portography, and MR imaging. Radiology 171:47, 1989PubMedGoogle Scholar
  10. 10.
    Nelson RC, Chezmar JL, Sugarbaker PH, Bernardino ME. Hepatic tumors: comparison of CT during arterial portography, delayed CT, and MR imaging for preoperative evaluation. Radiology 172:27, 1989PubMedGoogle Scholar
  11. 11.
    Freeny PC, Marks WM. Hepatic perfusion abnormalities during CT angiography. Radiology 159:685, 1986PubMedGoogle Scholar
  12. 12.
    Van Beers B, Pringot J, Gigot JF, Dauterbande J, Mathurin P. Non-tumorous attenuation differences on computed tomographic portography. Gastrointest Radiol 15:107, 1990PubMedCrossRefGoogle Scholar
  13. 13.
    Moss AA, Goldberg HI, Stark DB, et al. Hepatic tumors: magnetic resonance and CT appearance. Radiology 150:141, 1984PubMedGoogle Scholar
  14. 14.
    Ohtomo K, Itai Y, Yoshikawa K et al. Hepatic tumors: dynamic MR imaging. Radiology 163:27, 1987PubMedGoogle Scholar
  15. 15.
    Hamm B, Wolf KJ, Felix R. Conventional and rapid MR imaging of the liver with Gd-DTPA. Radiology 164:313, 1987PubMedGoogle Scholar
  16. 16.
    Van Beers, Demeure R, Pringot J, et al. Dynamic spin echo imaging with Gd-DTPA: value in the differentiation of hepatic tumors. AJR 154:515, 1990PubMedGoogle Scholar
  17. 17.
    Edelman RR, Siegal JB, Singer A, Dupuis K, Longmaid HE. Dynamic MR imaging of the liver with Gd-DTPA: initial clinical results. AJR 153:1213, 1989PubMedGoogle Scholar
  18. 18.
    Hamm B, Vogel TJ, Branding G, et al. Focal liver lesion: MR imaging with Mn-DPDP-initial clinical results in 40 patients. Radiology 182:167, 1992PubMedGoogle Scholar
  19. 19.
    Vogl TJ, Hammerstingl R, Schwarz W, et al. Superparamagnetic iron-oxide-enhanced MR imaging for differential diagnosis of focal liver lesions. Radiology 198:881, 1996PubMedGoogle Scholar
  20. 20.
    Stark DD, Weissleder R, Elizondo G, et al. Superparamagnetic iron oxide: clinical application as a contrast agent for MR imaging of the liver. Radiology 168:297, 1988PubMedGoogle Scholar
  21. 21.
    Marn CS, Bree RL, Silver TM. Ultrasonography of the liver: technique and focal and diffuse disease. Radiol Clin North Am 29:1151, 1991PubMedGoogle Scholar
  22. 22.
    Gaines PA, Sampson MA. The prevalence and characterization of simple hepatic cysts by ultrasound examination. Br J Radiol 62:335, 1989PubMedCrossRefGoogle Scholar
  23. 23.
    Spiegel RM, King DL, Green WM. Ultrasonography of primary cysts of the liver. AJR 131:235, 1978PubMedGoogle Scholar
  24. 24.
    Foley WD, Jochen RJ. Computed tomography: focal and diffuse liver disease. Radiol Clin North Am 29:1213, 1991PubMedGoogle Scholar
  25. 25.
    Kanzer GK, Weinreb JC. Magnetic resonance imaging of diseases of the liver and biliary system. Radiol Clin North Am 29:1259, 1991PubMedGoogle Scholar
  26. 26.
    Haaga JR. Magnetic resonance imaging of the liver. Radiol Clin North Am 22:879, 1984PubMedGoogle Scholar
  27. 27.
    Bree RL, Schwab RE, Glazer GM, et al. The varied appearances of hepatic cavernous hemangiomas with sonography, computed tomography, magnetic resonance imaging and scintigraphy. Radiographics 7:1153, 1987PubMedGoogle Scholar
  28. 28.
    Nelson RC, Chezmar JL. Diagnostic approaches to hepatic hemangiomas. Radiology 176:11, 1990PubMedGoogle Scholar
  29. 29.
    Marsh JI, Gibney RG, Li DKB. Hepatic hemangioma in the presence of fatty infiltration: an atypical sonographic appearance. Gastrointest Radiol 14:262, 1989PubMedCrossRefGoogle Scholar
  30. 30.
    Quinn SF, Benjamin GG. Hepatic cavernous hemangioma: simple diagnostic sign with dynamic bolus CT. Radiology 182:545, 1992PubMedGoogle Scholar
  31. 31.
    Leslie DF, Johnson CD, MacCarthy RL, et al. Single-pass CT of hepatic tumors: value of globular enhancement in distinguishing hemangiomas from hypervascular metastases. AJR 165:1403, 1995PubMedGoogle Scholar
  32. 32.
    Bressler EL, Alpern MB, Glazer GM, et al. Hypervascular hepatic metastases:CT evaluation. Radiology 162:49, 1987PubMedGoogle Scholar
  33. 33.
    Stark DD, Felder RC, Wittenberg J, et al. Magnetic resonance imaging of cavernous hemangioma of the liver: tissue-specific characterization. AJR 145:213, 1985PubMedGoogle Scholar
  34. 34.
    Ohtomo K, Itai Y, Furui S, et al. Hepatic tumor differentiation by transverse relaxation time (T2) of magnetic resonance imaging. Radiology 155:421, 1985PubMedGoogle Scholar
  35. 35.
    Egglin TK, Rummeny E, Stark DD, et al. Hepatic tumors: quantitative tissue characterization with MR imaging. Radiology 176:107, 1990PubMedGoogle Scholar
  36. 36.
    McFarland EG, Mayo-Smith WW, Saini S, et al. Hepatic hemangiomas and malignant tumors: improved differentiation with heavily T2-weighted conventional spin-echo MR imaging. Radiology 193: 43, 1994PubMedGoogle Scholar
  37. 37.
    Wittenberg J, Stark DD, Forman BH, et al. Differentiation of hepatic metastases from hepatic hemangiomas and cysts by using MR imaging. AJR 151:79, 1988PubMedGoogle Scholar
  38. 38.
    Ros PR, Lubbers PR, Olmsted WW, et al. Hemangioma of the liver: heterogeneous appearance on T2 weighted images. AJR 149:1167, 1987PubMedGoogle Scholar
  39. 39.
    Hamm B, Fischer E, Taupitz M. Differentiation of hepatic hemangiomas from metastases by dynamic contrast-enhanced MR imaging. J Comput Assist Tomogr 14:205, 1990PubMedCrossRefGoogle Scholar
  40. 40.
    Whitney WS, Herfkens RJ, Jeffrey RB, et al. Dynamic breath-hold multiplanar spoiled gradient-recalled MR imaging with gadolinium enhancement for differentiating hepatic hemangiomas from malignancies at 1.5 T. Radiology 189:863, 1993PubMedGoogle Scholar
  41. 41.
    Drane WE. Nuclear medicine techniques for the liver and biliary system: update for the 1990Æs. Radiol Clin North Am 29:1129, 1991PubMedGoogle Scholar
  42. 42.
    Wanless IR, Mawdsely C, Adams R. Pathogenesis of focal nodular hyperplasia. Hepatology 5:1194, 1985PubMedCrossRefGoogle Scholar
  43. 43.
    Welch TJ, Sheedy PF II, Johnson CM, et al. Focal nodular hyperplasia and hepatic adenoma: comparison of angiography, CT, ultrasound, and scintigraphy. Radiology 156:593, 1985PubMedGoogle Scholar
  44. 44.
    Rummeny E, Weissleder R, Stark DD, et al. Primary liver tumors: diagnosis by MR imaging. AJR 152:63, 1989PubMedGoogle Scholar
  45. 45.
    Lee MJ, Saini S, Hamm B, et al. Focal nodular hyperplasia of the liver: MR findings in 35 proved cases. AJR 156:317, 1991PubMedGoogle Scholar
  46. 46.
    Mattison GR, Glazer GM, Quint LE, et al. MR imaging of focal nodular hyperplasia: characterization and distinction from primary malignant hepatic tumors. AJR 148:711, 1987PubMedGoogle Scholar
  47. 47.
    Rummeny E, Weissleder R, Stark DD, Sironi S, et al. Central scars in primary liver tumors: MR features, specificity, and pathologic correlation. Radiology 171:323, 1989PubMedGoogle Scholar
  48. 48.
    Mathieu D, Rahmouni A, Anglade MC, et al. Focal nodular hyperplasia of the liver: assessment with contrast enhanced turbo-FLASH MR imaging. Radiology 180:25, 1991PubMedGoogle Scholar
  49. 49.
    Mahfouz AE, Hamm B, Taupitz M, et al. Hypervascular liver lesions: differentiation of focal nodular hyperplasia from malignant tumors with dynamic gadolinium-enhanced MR imaging. Radiology 186:133, 1993PubMedGoogle Scholar
  50. 50.
    Lubbers PR, Ros PR, Goodman ZD, et al. Accumulation of technetium-99m sulfur colloid by hepatocellular adenoma: scintigraphic-pathologic correlation. AJR 148:1105, 1987PubMedGoogle Scholar
  51. 51.
    Arrive L, Flejou JF, Vilgrain V, et al. Hepatic adenoma: MR findings in 51 pathologically proved lesions. Radiology 193:507, 1994PubMedGoogle Scholar
  52. 52.
    Scartarige JC, Scott WW, Donovan PJ, et al. Fatty infiltration of the liver: ultrasonographic and computed tomographic correlation. J Ultrasound Med 3:9, 1984Google Scholar
  53. 53.
    Wang SS, Chiang JH, Bai YT, et al. Focal hepatic fatty infiltration as a cause of pseudotumors: ultrasonographic patterns and clinical differentiation. J Clin Ultrasound 18:401, 1990PubMedCrossRefGoogle Scholar
  54. 54.
    Yates CH, Streight FA. Focal fatty infiltration of the liver simulating metastatic disease. Radiology 159:83, 1986PubMedGoogle Scholar
  55. 55.
    Mitchell DG. Focal manifestations of diffuse liver disease at MR imaging. Radiology 185:1, 1992PubMedGoogle Scholar
  56. 56.
    Moss AA, Dean BP, Axel L, et al. Dynamic CT of hepatic masses with intravenous and intra-arterial contrast material. AJR 138:847, 1982PubMedGoogle Scholar
  57. 57.
    Seneterre E, Taourel P, Bouvier Y, et al. Detection of hepatic metastases: ferrumoxides-enhanced MR imaging versus unenhanced MR imaging and CT during arterial portography. Radiology 200:785, 1996PubMedGoogle Scholar
  58. 58.
    Curati WL, Halevy A, Gibson RN, et al. Ultrasound, CT, and MRI comparison in primary and secondary tumors of the liver. Gastrointest Radiol 13:123, 1988PubMedCrossRefGoogle Scholar
  59. 59.
    Tanaka S, Kitamura T, Imaoka Y, et al. Hepatocellular carcinoma: Sonographic and histologic correlation. AJR 140:701, 1983PubMedGoogle Scholar
  60. 60.
    Larson RE, Semelks RC, Bagley AS, et al. Hypervascular malignant liver lesions: comparison of various MR imaging pulse sequences and dynamic CT. Radiology 192:393, 1994PubMedGoogle Scholar
  61. 61.
    Caseiro-Alves F, Zins M, Mahfouz AE et al. Calcification in focal nodular hyperplasia: a new problem for differentiation from fibrolamellar hepatocellular carcinoma. Radiology 198:889, 1996PubMedGoogle Scholar
  62. 62.
    Cohen SM, Kurtz AB. Biliary sonography. Radiol Clin North Am 29:1171, 1991PubMedGoogle Scholar
  63. 63.
    Baron RL. Computed tomography of the biliary tree. Radiol Clin North Am 29:1235, 1991PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Revathy Iyer
  • Chusilp Charnsangavej

There are no affiliations available

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