Cell Growth and Senescence
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A living human cell is both a single entity and part of a multicellular organism. Cancer is a disease of uncontrolled cell growth, where a cell with mutated DNA stops following the normal instructions that govern its life as part of the organism. A cancer cell is a rebel. The fall from normal law abiding cooperation to self-perpetuating out-of-control rebellion is not a single step. Cancer cells may be only slightly deranged, paralleling the functions of their normal counterparts. This results in a slow growing, well differentiated tumor. However, with each successive cell division, cancer cells lose more of their control. The cancer progressively becomes a fast growing dedifferentiated tumor where the malignant cells are guided only by primitive internal instructions that speed their replication.
KeywordsCell Cycle Checkpoint Xeroderma Pigmentosum Ataxia Telangiectasia Cell Division Cycle Uncontrolled Cell Growth
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