Advertisement

Molecular Anticancer Therapies

  • Dennis W. Ross
Chapter
  • 85 Downloads

Abstract

Cancer results from a series of gene mutations that disrupt normal controls on cell growth. It is worth repeating this definition now, near the end of the book, in order to focus our discussion of molecular anticancer therapies. The most important result of the discoveries of molecular biology applied to cancer is knowledge. Knowledge provides a rational basis for therapy. We want new therapies aimed at the molecular lesions we have discovered. The most direct approach is to fix the mutations in DNA through genetic engineering. If we cannot do that, we can try to block abnormal gene function by interfering with transcription or translation. Alternatively, we can intervene at a later step with antibodies to abnormal oncoproteins.

Keywords

Tumor Suppressor Gene Genetic Engineering Familial Adenomatous Polyposis Antisense Oligonucleotide Oral Polio Vaccine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Askari FK, McDonnell WM. Molecular medicine: antisense-oligonucleotiede therapy. New Engl J Med. 1996;334:316–318.PubMedCrossRefGoogle Scholar
  2. Bischoff JR, Kirn DH, Williams A, et al. An adenovirus mutant that replicates selectively in p53-deficient human tumor cells. Science. 1996;274:373–376.PubMedCrossRefGoogle Scholar
  3. Blaese MR. Gene therapy for cancer. Sci Am. 1997;July:111–115.Google Scholar
  4. Current clinical trials in oncology. Physician’s data query (PDQ) on-line database, National Cancer Institute. (Also published bimonthly by Pyros Education Group, Green Brook, NJ.)Google Scholar
  5. Ho PTC, Parkinson DR. Antisense oligonucleotides as therapeutics for malignant diseases. Semin Oncol. 1997;24:1–17.Google Scholar
  6. Kevles DJ, Hood L, eds. The Code of Codes: Scientific and Social Issues in the Human Genome Project. Cambridge: Harvard University Press; 1992.Google Scholar

Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Dennis W. Ross
    • 1
  1. 1.Department of PathologyForsyth Medical CenterWinston-SalemUSA

Personalised recommendations