Molecular Anticancer Therapies

  • Dennis W. Ross


Cancer results from a series of gene mutations that disrupt normal controls on cell growth. It is worth repeating this definition now, near the end of the book, in order to focus our discussion of molecular anticancer therapies. The most important result of the discoveries of molecular biology applied to cancer is knowledge. Knowledge provides a rational basis for therapy. We want new therapies aimed at the molecular lesions we have discovered. The most direct approach is to fix the mutations in DNA through genetic engineering. If we cannot do that, we can try to block abnormal gene function by interfering with transcription or translation. Alternatively, we can intervene at a later step with antibodies to abnormal oncoproteins.


Tumor Suppressor Gene Genetic Engineering Familial Adenomatous Polyposis Antisense Oligonucleotide Oral Polio Vaccine 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Dennis W. Ross
    • 1
  1. 1.Department of PathologyForsyth Medical CenterWinston-SalemUSA

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