Molecular Anticancer Therapies
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Cancer results from a series of gene mutations that disrupt normal controls on cell growth. It is worth repeating this definition now, near the end of the book, in order to focus our discussion of molecular anticancer therapies. The most important result of the discoveries of molecular biology applied to cancer is knowledge. Knowledge provides a rational basis for therapy. We want new therapies aimed at the molecular lesions we have discovered. The most direct approach is to fix the mutations in DNA through genetic engineering. If we cannot do that, we can try to block abnormal gene function by interfering with transcription or translation. Alternatively, we can intervene at a later step with antibodies to abnormal oncoproteins.
KeywordsTumor Suppressor Gene Genetic Engineering Familial Adenomatous Polyposis Antisense Oligonucleotide Oral Polio Vaccine
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- Blaese MR. Gene therapy for cancer. Sci Am. 1997;July:111–115.Google Scholar
- Current clinical trials in oncology. Physician’s data query (PDQ) on-line database, National Cancer Institute. (Also published bimonthly by Pyros Education Group, Green Brook, NJ.)Google Scholar
- Ho PTC, Parkinson DR. Antisense oligonucleotides as therapeutics for malignant diseases. Semin Oncol. 1997;24:1–17.Google Scholar
- Kevles DJ, Hood L, eds. The Code of Codes: Scientific and Social Issues in the Human Genome Project. Cambridge: Harvard University Press; 1992.Google Scholar