Compartmental Models in Metabolic Studies: Vitamin C
STELLA® and similar computer programs allow one to use modeling and simulation as a tool for thinking. However, no one has time to squander; our modeling should have a purpose. Also, in coming to grips with questions, one must consider the rich source of data that is already available in the scientific literature. Modeling has been used as a quantitative tool to answer many significant medical questions, and simulation programs such as STELLA® may be used to interpret this information. Much of this information has been reported in a format derived from compartmental analysis. The purpose of this chapter is to introduce this method and ideas about using STELLA® to help interpret this kinetic information. Let us note that the comment quoted above concerning model development and testing implies a need to apply statistical methods to ensure that a model functions in a robust manner. However, it is reasonable for the student to use models that have already been developed with these research methods.
KeywordsCholesterol Toxicity Norepinephrine Smoke Oxalate
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