Nutritional Support of the Neonate II: The Rationale for Human Milk Feeding

  • Richard J. Schanler


Human milk is recommended as the exclusive nutrient source for feeding full-term infants during the first 6 months after birth and should be continued, with the addition of solid foods, at least through the first 12 months.1,2 The recommendation for human milk feeding arises because of its acknowledged benefits with respect to infant nutrition, gastrointestinal function, host defense, and psychological well-being. The recognition of beneficial effects in premature infants is emerging to support the feeding of human milk.3 Favorable outcomes of breast-feeding are reported for both infants and mothers.


Premature Infant Human Milk Milk Intake Milk Volume Milk Expression 
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  1. 1.
    American Academy of Pediatrics, Committee on Nutrition. Encouraging breast-feeding. Pediatrics 1980; 65: 657–658.Google Scholar
  2. 2.
    Nutrition Committee of the Canadian Paediatric Society, Committee on Nutrition of the American Academy of Pediatrics. Breast-feeding. Pediatrics 1978; 62: 591–601.Google Scholar
  3. 3.
    Nutrition Committee, Canadian Paediatric Society. Nutrient needs and feeding of premature infants. Can Med Assoc J 1995; 152: 1765–1785.Google Scholar
  4. 4.
    American Academy of Pediatrics, Committee on Nutrition. Nutrition and lactation. Pediatrics 1981; 68: 435–433.Google Scholar
  5. 5.
    Atkinson SA, Bryan MH, Anderson GH. Human milk: difference in nitrogen concentration in milk from mothers of term and premature infants. J Pediatr 1978; 93: 67–69.PubMedCrossRefGoogle Scholar
  6. 6.
    Butte NF, Garza C, Johnson CA, et al. Longitudinal changes in milk composition of mothers delivering pre-term and term infants. Early Hum Dev 1984; 9: 153–162.PubMedCrossRefGoogle Scholar
  7. 7.
    Schanler RJ, Oh W. Composition of breast milk obtained from mothers of premature infants as compared to breast milk obtained from donors. J Pediatr 1980; 96: 679–681.PubMedCrossRefGoogle Scholar
  8. 8.
    Gross SJ, David RJ, Bauman L, et al. Nutritional composition of milk produced by mothers delivering preterm. J Pediatr 1980; 96: 641–644.PubMedCrossRefGoogle Scholar
  9. 9.
    Carlson SE. Human milk nonprotein nitrogen: occurrence and possible functions. In: Barness LA, ed. Advances in pediatrics. Chicago: Year Book Medical 1985: 43–70.Google Scholar
  10. 10.
    Hambraeus L. Proprietary milk versus human breast milk in infant feeding, a critical appraisal from the nutritional point of view. Pediatr Clin North Am 1977; 24: 17–35.PubMedGoogle Scholar
  11. 11.
    Heine W, Tiess M, Wutzke KD. 15N tracer investigations of the physiological availability of urea nitrogen in mother’s milk. Acta Paediatr Scand 1986; 75: 439–443.PubMedCrossRefGoogle Scholar
  12. 12.
    Fomon SJ, Bier DM, Matthews DE, et al. Bioavailability of dietary urea nitrogen in the breast-fed infant. J Pediatr 1988; 113: 515–517.PubMedCrossRefGoogle Scholar
  13. 13.
    Billeaud C, Guillet J, Sandler B. Gastric emptying in infants with or without gastro-oesophageal reflux according to the type of milk. Eur J Clin Nutr 1990; 44: 577–583.PubMedGoogle Scholar
  14. 14.
    Rassin DK, Gaull GE, Raiha NCR, et al. Milk protein quantity and quality in low-birth-weight infants. IV. Effects on tyrosine and phenylalanine in plasma and urine. J Pediatr 1977; 90: 356–360.PubMedCrossRefGoogle Scholar
  15. 15.
    Gaull GE, Rassin DK, Raiha NCR, et al. Milk protein quantity and quality in low-birthweight infants. III. Effects on sulfur amino acids in plasma and urine. J Pediatr 1977; 90: 348–355.PubMedCrossRefGoogle Scholar
  16. 16.
    Jarvenpaa AL, Raiha NC, Rassin DK. Feeding the lowbirth-weight infant: I. Taurine and cholesterol supplementation of formula does not affect growth and metabolism. Pediatrics 1983; 71: 171–178.PubMedGoogle Scholar
  17. 17.
    Jarvenpaa AL, Rassin DK, Raiha NCR, et al. Milk protein quantity and quality in the term infant. II. Effects on acidic and neutral amino acids. Pediatrics 1982; 70: 221–230.PubMedGoogle Scholar
  18. 18.
    Rassin DK. Amino acid responses in neonatal nutrition and their implications for the central nervous system. In: Barness L, ed. Protein requirements in the term infant. Princeton: Excerpta Medica, 1988: 3–9.Google Scholar
  19. 19.
    Lindblad BS, Alfven G, Zetterstrom R. Plasma free amino acid concentrations of breast-fed infants. Acta Paediatr Scand 1978; 67: 659–663.PubMedCrossRefGoogle Scholar
  20. 20.
    Goldman AS, Chheda S, Keeney SE, et al. Immunologic protection of the premature newborn by human milk. Semin Perinatol 1994; 18: 495–501.PubMedGoogle Scholar
  21. 21.
    Lonnerdal B. Biochemistry and physiological function of human milk proteins. Am J Clin Nutr 1985; 42: 1299 1317.Google Scholar
  22. 22.
    Hanson LA, Ahlstedt S, Andersson B, et al. Protective factors in milk and the development of the immune system. Pediatrics 1985; 75 (suppl): 172–176.PubMedGoogle Scholar
  23. 23.
    Hernell O, Blackberg L. Human milk bile salt-stimulated lipase: functional and molecular aspects. J Pediatr 1994; 125: S56–61.PubMedCrossRefGoogle Scholar
  24. 24.
    Jensen RG, Hagerty MM, McMahon KE. Lipids of human milk and infant formulas: a review. Am J Clin Nutr 1978; 31: 990–1016.PubMedGoogle Scholar
  25. 25.
    Jensen RG, Jensen GL. Specialty lipids for infant nutrition. I. Milks and formulas. J Pediatr Gastroenterol Nutr 1992; 15: 232–245.PubMedCrossRefGoogle Scholar
  26. 26.
    Alemi B, Hamosh M, Scanlon JW, et al. Fat digestion in very low-birthweight infants: effect of addition of human milk to low birthweight formula. Pediatrics 1981; 68: 484–489.PubMedGoogle Scholar
  27. 27.
    Butte NF, Garza C, Smith EO. Variability of macronutrient concentrations in human milk. Eur J Clin Nutr 1988; 42: 345–349.PubMedGoogle Scholar
  28. 28.
    Hamosh M. Lipid metabolism in premature infants. Biol Neonate 1987; 52 (suppl 1): 50–64.PubMedCrossRefGoogle Scholar
  29. 29.
    Neville MC, Keller RP, Seacat J, et al. Studies on human lactation. I. Within-feed and between-breast variation in selected components of human milk Am J Clin Nutr 1984; 40: 635–646.Google Scholar
  30. 30.
    Valentine CJ, Hurst NM, Schanler RJ. Hindmilk improves weight gain in low-birth-weight infants fed human milk. J Pediatr Gastroenterol Nutr 1994; 18: 474–477.PubMedCrossRefGoogle Scholar
  31. 31.
    Nommsen LA, Lovelady CA, Heinig MJ, et al. Determinants of energy, protein, lipid, and lactose concentrations in human milk during the first 12 months of lactation: the DARLING study. Am J Clin Nutr 1991; 53: 457–465.PubMedGoogle Scholar
  32. 32.
    Butte NF, Garza C, Stuff JE, et al. Effect of maternal diet and body composition on lactational performance. Am J Clin Nutr 1984; 39: 296–306.PubMedGoogle Scholar
  33. 33.
    Greer FR, McCormick A, Loker J. Changes in fat concentration of human milk during delivery by intermittent bolus and continuous mechanical pump infusion. J Pediatr 1984; 105: 745–749.PubMedCrossRefGoogle Scholar
  34. 34.
    Schanler RJ. Special methods in feeding the preterm infant. In: Tsang RC, Nichols BL, eds. Nutrition during infancy. Philadelphia: Hanley & Belfus, 1988: 314–325.Google Scholar
  35. 35.
    Uauy R, Hoffman DR. Essential fatty acid requirements for normal eye and brain development. Semin Perinatol 1991; 15: 449–455.PubMedGoogle Scholar
  36. 36.
    Innis SM. Human milk and formula fatty acids. J Pediatr 1992; 120: S56–S61.PubMedCrossRefGoogle Scholar
  37. 37.
    Carlson SE, Werkman SH, Rhodes PG, et al. Visual-acuity development in healthy preterm infants: effect of marine-oil supplementation. Am J Clin Nutr 1993; 58: 35–42.PubMedGoogle Scholar
  38. 38.
    Whyte RK, Homer R, Pennock CA. Faecal excretion of oligosaccharides and other carbohydrates in normal neonates. Arch Dis Child 1978; 53: 913–915.PubMedCrossRefGoogle Scholar
  39. 39.
    MacLean WC, Fink BB. Lactose malabsorption by premature infants: magnitude and clinical significance. J Pediatr 1980; 97: 383–388.PubMedCrossRefGoogle Scholar
  40. 40.
    Ziegler EE, Fomon SJ. Lactose enhances mineral absorption in infancy. J Pediatr Gastroenterol Nutr 1983; 2: 288–294.PubMedGoogle Scholar
  41. 41.
    Schanler RJ. Suitability of human milk for the low birth-weight infant. Clin Perinatol 1995; 22: 207–222.PubMedGoogle Scholar
  42. 42.
    Neville MC, Watters CD. Secretion of calcium into milk: a review. J Dairy Sci 1983; 66: 371–380.PubMedCrossRefGoogle Scholar
  43. 43.
    Casey CE, Hambidge KM, Neville MC. Studies in human lactation: zinc, copper, manganese, and chromium in human milk in the first month of lactation. Am J Clin Nutr 1985; 41: 1193–1200.PubMedGoogle Scholar
  44. 44.
    Dallman PR, Siimes MA, Stekel A. Iron deficiency in infancy and childhood. Am J Clin Nutr 1980; 33: 86–118.PubMedGoogle Scholar
  45. 45.
    Saarinen UM. Need for iron supplementation in infants on prolonged breast-feeding. J Pediatr 1978; 93: 177–180.PubMedCrossRefGoogle Scholar
  46. 46.
    Lonnerdal B, Hernell O. Iron, zinc, copper and selenium status of breast-fed infants and infants fed trace element fortified milk-based infant formula. Acta Pediatr 1994; 83: 367–373.CrossRefGoogle Scholar
  47. 47.
    Schanler RJ, Prestridge LL. Neonatal vitamin metabolism-water soluble. In: Cowett RM, ed. Principles of perinatal-neonatal metabolsim. New York: Springer-Verlag, 1991: 559–582.CrossRefGoogle Scholar
  48. 48.
    Greer FR, Suttie JW. Vitamin K and the newborn. In: Tsang RC, Nichols BL, eds. Nutrition during infancy. Philadelphia: Hanley & Belfus, 1988: 289–297.Google Scholar
  49. 49.
    Specker BL, Greer F, Tsang RC. Vitamin D. In: Tsang RC, Nichols BL, eds. Nutrition during infancy. Philadelphia: Hanley & Belfus, 1988: 264–276.Google Scholar
  50. 50.
    Carver JD, Walker WA. The role of nucleotides in human nutrition. Nutr Biochem 1995; 6: 58–72.CrossRefGoogle Scholar
  51. 51.
    Uauy R, Quan R, Gil A. Role of nucleotides in intestinal development and repair: implications for infant nutrition. J Nutr 1994; 124: 1436S–1441S.PubMedGoogle Scholar
  52. 52.
    Koldovsky O. The potential physiological significance of milk-borne hormonally active substances for the neonate. J Mammary Gland Biol Neoplasia 1996; 1: 317–323.PubMedCrossRefGoogle Scholar
  53. 53.
    Prosser CG. Insulin-like growth factors in milk and mammary gland. J Mammary Gland Biol Neoplasia 1996; 1: 297–306.PubMedCrossRefGoogle Scholar
  54. 54.
    Ellis LA, Mastro AM, Picciano MF. Milk-borne prolactin and neonatal development. J Mammary Gland Biol Neoplasia 1996; 1: 259–269.PubMedCrossRefGoogle Scholar
  55. 55.
    Sheard NF, Walker WA. The role of breast milk in the development of the gastrointestinal tract. Nutr Rev 1988; 46: 1–8.PubMedCrossRefGoogle Scholar
  56. 56.
    Hanson LA, Adlerberth I, Carlsson B, et al. Host defense of the neonate and the intestinal flora. Acta Paediatr Scand Suppl 1989; 351: 122–125.PubMedCrossRefGoogle Scholar
  57. 57.
    Goldman AS, Sharpe LW, Goldblum RM. Anti-inflammatory properties of human milk. Acta Paediatr Scand 1986; 75: 689–695.PubMedCrossRefGoogle Scholar
  58. 58.
    Goldman AS, Smith CW. Host resistance factors in human milk. J Pediatr 1973; 82: 1082–1090.PubMedCrossRefGoogle Scholar
  59. 59.
    Nuijens JH, van Berkel PHC, Schanbacher FL. Structure and biological actions of lactoferrin. J Mammary Gland Biol Neoplasia 1996; 1: 285–295.PubMedCrossRefGoogle Scholar
  60. 60.
    Telemo E, Hanson LA. Antibodies in milk. J Mammary Gland Biol Neoplasia 1996; 1: 243–249.PubMedCrossRefGoogle Scholar
  61. 61.
    Kleinman RE, Walker WA. The enteromammary immune system. Dig Dis Sci 1979; 24: 876–882.PubMedCrossRefGoogle Scholar
  62. 62.
    Fishaut M, Murphy D, Neifert M, et al. Bronchomammary axis in the immune response to respiratory syncytial virus. J Pediatr 1981; 99: 186–191.PubMedCrossRefGoogle Scholar
  63. 63.
    Isaacs CE, Kashyap S, Heird WC, et al. Antiviral and antibacterial lipids in human milk and infant formula feeds. Arch Dis Child 1990; 65: 861–864.PubMedCrossRefGoogle Scholar
  64. 64.
    Newburg DS. Oligosaccharides and glycoconjugates in human milk: their role in host defense. J Mammary Gland Biol Neoplasia 1996; 1: 271–283.PubMedCrossRefGoogle Scholar
  65. 65.
    Goldman AS, Chheda S, Garofalo R, et al. Cytokines in human milk: properties and potential effects upon the mammary gland and the neonate. J Mammary Gland Biol Neoplasia 1996; 1: 351–358.Google Scholar
  66. 66.
    Institute of Medicine, Subcommittee on Nutrition During Lactation. Nutrition during lactation. Washington, DC: National Academy Press, 1991.Google Scholar
  67. 67.
    Neville MC, Keller R, Seacat J, et al. Studies in human lactation: milk volumes in lactating women during the onset of lactation and full lactation. Am J Clin Nutr 1988; 48: 1375–1386.PubMedGoogle Scholar
  68. 68.
    Macy IG, Hunscher HA, Donelson E, et al. Human milk flow. J Dis Child 1930; 39: 1186–1204.Google Scholar
  69. 69.
    Saint L, Maggiore P, Hartmann PE. Yield and nutrient content of milk in eight women breast-feeding twins and one woman breast-feeding triplets. Br J Nutr 1986; 56: 87–95.CrossRefGoogle Scholar
  70. 70.
    Stuff JE, Nichols BL. Nutrient intake and growth performance of older infants fed human milk. J Pediatr 1989; 116: 959–968.Google Scholar
  71. 71.
    Dewey KG, Heinig MJ, Nommsen LA, et al. Adequacy of energy intake among breast-fed infants in the DARLING study: relationships to growth velocity, morbidity, and activity levels. J Pediatr 1991; 119: 538–547.PubMedCrossRefGoogle Scholar
  72. 72.
    Dewey KG, Heinig MJ, Nommsen LA, et al. Maternal vs infant factors related to breast milk intake and residual milk volume: the DARLING study. Pediatrics 1991; 87: 829–837.PubMedGoogle Scholar
  73. 73.
    Michaelsen KF, Larsen PS, Thomsen BL, et al. Weight, length, head circumference, and growth velocity in a longitudinal study of Danish infants. Dan Med Bull 1994; 41: 577–585.PubMedGoogle Scholar
  74. 74.
    Schanler RJ, Hurst NM. Human milk for the hospitalized preterm infant. Semin Perinatol 1994; 18: 476–484.PubMedGoogle Scholar
  75. 75.
    Hopkinson JM, Schanler RJ, Garza C. Milk production by mothers of premature infants. Pediatrics 1988; 81: 815–820.PubMedGoogle Scholar
  76. 76.
    Hopkinson JM, Schanler RJ, Fraley JK, et al. Milk production by mothers of premature infants: influence of cigarette smoking. Pediatrics 1992; 90: 934–938.PubMedGoogle Scholar
  77. 77.
    Vio F, Salazar G, Infante C. Smoking during pregnancy and lactation and its effect on breast-milk volume. Am J Clin Nutr 1991; 54: 1011–1016.PubMedGoogle Scholar
  78. 78.
    Andersen AN, Lund-Andersen C, Larsen JF, et al. Suppressed prolactin but normal neurophysin levels in cigarette smoking breast-feeding women. Clin Endocrinol 1982; 17: 363–368.CrossRefGoogle Scholar
  79. 79.
    Winikoff B, Semeraro P, Zimmerman M. Contraception during breast-feeding: a clinician’s handbook. New York: Population Council, 1988.Google Scholar
  80. 80.
    Hurst N, Valentine C, Renfro L, et al. Skin-to-skin holding in the neonatal intensive care influences maternal milk volume. J Perinatol 1997; 36: 551–559.Google Scholar
  81. 81.
    Prentice A, Paul A, Black A, et al. Cross-cultural differences in lactational performance. In: Hamosh M, Goldman AS, eds. Human lactation 2: maternal and environmental factors. New York: Plenum Press, 1986: 13–44.Google Scholar
  82. 82.
    Strode MA, Dewey KG, Lonnerdal B. Effects of short-term caloric restriction on lactational performance of well-nourished women. Acta Paediatr Scand 1986; 75: 222–229.PubMedCrossRefGoogle Scholar
  83. 83.
    Neville M, Oliva-Rasbach J. Is maternal milk production limiting for infant growth during the first year of life in breast-fed infants? In: Goldman AS, Atkinson SA, Hanson LA, eds. Human lactation 3: the effects of human milk on the recipient infant. New York: Plenum Press, 1987: 123–133.Google Scholar
  84. 84.
    Dusdieker LB, Hemingway DL, Stumbo PJ. Is milk production impaired by dieting during lactation? Am J Clin Nutr 1994; 59: 833–840.PubMedGoogle Scholar
  85. 85.
    Lonnerdal B, Forsum E, Gebre-Medhin M, et al. Breast milk composition in Ethiopian and Swedish mothers. II. Lactose, nitrogen, and protein contents. Am J Clin Nutr 1976; 29: 1134–1141.PubMedGoogle Scholar
  86. 86.
    Villalpando SF, Butte NF, Wong WW, et al. Lactation performance of rural Mesoamerindians. Eur J Clin Nutr 1992; 46: 337–348.PubMedGoogle Scholar
  87. 87.
    Sanchez-Pozo A, Lopez-Morles J, Izquierdo A, et al. Protein composition of human milk in relation to mother’s weight and socioeconomic status. Hum Nutr Clin Nutr 1987; 41C: 115–125.PubMedGoogle Scholar
  88. 88.
    Forsum E, Lonnerdal B. Effect of protein intake on protein and nitrogen composition of breast milk. Am J Clin Nutr 1980; 33: 1809–1813.PubMedGoogle Scholar
  89. 89.
    Jensen RG. The lipids of human milk. Boca Raton, FL: CRC Press, 1989.Google Scholar
  90. 90.
    JE Chappell T Francis MT Clandinin Vitamin A and E content of human milk at early stages of lactation. 1985;11:157–167PubMedCrossRefGoogle Scholar
  91. 91.
    Hachey DL, Silber GH, Wong WW, et al. Human lactation II: endogenous fatty acid synthesis by the mammary gland. Pediatrics 1989; 25: 63–68.Google Scholar
  92. 92.
    Sanders THB, Ellis TR, Dickerson JWT. Studies of vegans: the fatty acid composition of plasma cholinephosphoglycerides, erythrocytes, adipose tissue, breast milk and some indicators of susceptibility to ischemic heart disease in vegans and omnivore controls. Am J Clin Nutr 1978; 31: 805–813.PubMedGoogle Scholar
  93. 93.
    Butte NF, Calloway DH. Evaluation of lactational performance of Navajo women. Am J Clin Nutr 1981; 34: 2210–2215.PubMedGoogle Scholar
  94. 94.
    Gebre-Medhin M, Vahlquist A, Hofvander Y, et al. Breast milk composition in Ethiopian and Swedish mothers. I. Vitamin A and 13-carotene. Am J Clin Nutr 1976; 29: 441–451.PubMedGoogle Scholar
  95. 95.
    Hollis BW, Lambert PW, Horst RL. Factors affecting the antirachitic sterol content of native milk. In: Holick MF, Gray TK, Anast CS, eds. Perinatal calcium and phosphorous metabolism. Amsterdam: Elsevier, 1983: 157–182.Google Scholar
  96. 96.
    von Kries R, Shearer M, McCarthy PT, et al. Vitamin K1 content of maternal milk: influence of the stage of lactation, lipid composition, and vitamin K1 supplements given to the mother. Pediatr Res 1987; 22: 513–517.CrossRefGoogle Scholar
  97. 97.
    Bates CJ, Prentice AM, Prentice A, et al. The effect of vitamin C supplementation on lactating women in Keneba, a West African rural community. Int J Vitam Nutr Res 1983; 53: 68–76.PubMedGoogle Scholar
  98. 98.
    Byerley LO, Kirksey A.Effects of different levels of vitamin C intake on the vitamin C concentration in human milk and the vitamin C intakes of breast-fed infants. Am J Clin Nutr 1985; 41:665–671.PubMedGoogle Scholar
  99. 99.
    Pratt JP, Hamil BM, Moyer EZ, et al. Metabolism of women during the reproductive cycle. XVIII. The effect of multi-vitamin supplements on the secretion of B vitamins in human milk. J Nutr 1951; 44: 141–157.PubMedGoogle Scholar
  100. 100.
    Kirksey A, Roepke JLB. Vitamin B6 nutriture of mothers of three breast-fed neonates with central nervous system disorders. Fed Proc 1981; 40: 864.Google Scholar
  101. 101.
    Johnson PR Jr, Roloff JS. Vitamin Bt12 deficiency in an infant strictly breast-fed by a mother with latent pernicious anemia. J Pediatr 1982; 100: 917–919.PubMedCrossRefGoogle Scholar
  102. 102.
    Higginbottom MC, Sweetman L, Nyhan WL. A syndrome of methylmalonic aciduria, homocystinuria, megaloblastic anemia and neurologic abnormalities in a vitamin B12 deficient breast-fed infant of a strict vegetarian. N Engl J Med 1978; 299: 317–323.PubMedCrossRefGoogle Scholar
  103. 103.
    Specker BL, Miller D, Norman EJ, et al. Increased urinary methylmalonic acid excretion in breast-fed infants of vegetarian mothers and identification of an acceptable dietary source of vitamin B12. Am J Clin Nutr 1988; 47: 89–92.PubMedGoogle Scholar
  104. 104.
    Laskey MA, Prentice A, Shaw J, et al. Breast-milk calcium concentrations during prolonged lactation in British and rural Gambian mothers. Acta Paediatr Scand 1990; 79: 507–512.PubMedCrossRefGoogle Scholar
  105. 105.
    Prentice A, Barclay DV. Breast-milk calcium and phosphorus concentrations of mothers in rural Zaire. Eur J Clin Nutr 1991; 45: 611–617.PubMedGoogle Scholar
  106. 106.
    Dallman PR. Iron deficiency in the weaning: a nutritional problem on the way to resolution. Acta Paediatr Scand 1986; S323: 59–67.CrossRefGoogle Scholar
  107. 107.
    Siimes MA, Salmenpera L, Perheentupa J. Exclusive breast-feeding for 9 months: risk of iron deficiency. J Pediatr 1984; 104: 196–199.PubMedCrossRefGoogle Scholar
  108. 108.
    Lonnerdal B, Keen CL, Hurley LS. Iron, copper, zinc, and manganese in milk. Annu Rev Nutr 1981; 1: 149–174.PubMedCrossRefGoogle Scholar
  109. 109.
    Krebs NF, Reidinger CJ, Hartley S, et al. Zinc supplementation during lactation: effects on maternal status and milk zinc concentrations. Am J Clin Nutr 1995; 61: 1030–1036.PubMedGoogle Scholar
  110. 110.
    Mannan S, Picciano MF, Influence of maternal selenium status on human milk selenium concentration and glutathione peroxidase activity. Am J Clin Nutr 1987; 46: 95–100.PubMedGoogle Scholar
  111. 111.
    Ruff AJ. Breastmilk, breastfeeding, and transmission of viruses to the neonate. Semin Perinatol 1994; 18: 510–516.PubMedGoogle Scholar
  112. 112.
    Dworsky M, Yow M, Stagno S, et al. Cytomegalovirus infection of breast milk and transmission in infancy. Pediatrics 1983; 72: 295–299.PubMedGoogle Scholar
  113. 113.
    Krogh V, Duffy C, Wong D, et al. Postpartum immunization with rubella virus vaccine and antibody response in breast-feeding infants. J Lab Clin Med 1989; 113: 695–699.PubMedGoogle Scholar
  114. 114.
    Martino MD, Appendino C, Resti M, et al. Should hepatitis B surface antigen positive mothers breast-feed? Arch Dis Child 1985; 60: 972–974.PubMedCrossRefGoogle Scholar
  115. 115.
    Dunn DT, Newell ML, Ades AE, et al. Risk of human immunodeficiency virus type 1 transmission through breast-feeding. Lancet 1992; 340: 585–588.PubMedCrossRefGoogle Scholar
  116. 116.
    Palasanthiran P, Ziegler JB, Stewart GJ, et al. Breast-feeding during primary maternal human immunodeficiency virus infection and risk of transmission from mother to infant. J Infect Dis 1993; 167: 441–444.PubMedCrossRefGoogle Scholar
  117. 117.
    Oxtoby MJ. Human immunodeficiency virus and other viruses in human milk: placing the issues in broader perspective. Pediatr Infect Dis J 1988; 7: 825–835.PubMedGoogle Scholar
  118. 118.
    American Academy of Pediatrics, Peter G, ed. 1997 Red Book: Report of the Committee on Infectious Diseases. 24nd ed. Elk Grove Village, IL: AAP, 1994.Google Scholar
  119. 119.
    American Academy of Pediatrics, Committee on Drugs. The transfer of drugs and other chemicals into human milk. Pediatrics 1994; 93: 137–150.Google Scholar
  120. 120.
    Berlin CM, Denson M, Daniel CH, et al. Disposition of dietary caffeine in milk, saliva, and plasma of lactating women. Pediatrics 1984; 73: 59–63.PubMedGoogle Scholar
  121. 121.
    Menella JA, Beauchamp GK. The transfer of alcohol to human milk. Effects on flavor and the infant’s behavior. N Engl J Med 1991; 325: 981–985.CrossRefGoogle Scholar
  122. 122.
    Little RE, Anderson KW, Ervin CH, et al. Maternal alcohol use during breast-feeding and infant mental and motor development at one year. N Engl J Med 1989; 321: 425–430.PubMedCrossRefGoogle Scholar
  123. 123.
    Hillman LS, Chow W, Salmons SS, et al. Vitamin D metabolism, mineral homeostasis, and bone mineralization in term infants fed human milk, cow milk-based formula, or soy-based formula. J Pediatr 1988; 112: 864–874.PubMedCrossRefGoogle Scholar
  124. 124.
    Venkataraman PS, Luhar H, Neylan MJ. Bone mineral metabolism in full-term infants fed human milk, cow milk-based, and soy-based formulas. Am J Dis Child 1992; 146: 1302–1305.PubMedGoogle Scholar
  125. 125.
    Greer FR, Searcy JE, Levin RS, et al. Bone mineral content and serum 25-hydroxyvitamin D concentration in breast-fed infants with and without supplemental vitamin D. J Pediatr 1981; 98: 696–701.PubMedCrossRefGoogle Scholar
  126. 126.
    Greer FR, Searcy JE, Levin RS, et al. Bone mineral content and serum 25-OH D concentrations in breast-fed infants with and without supplemental vitamin D: one year follow-up. J Pediatr 1982; 100: 919–922.PubMedCrossRefGoogle Scholar
  127. 127.
    Popkin BM, Adair L, Akin JS, et al. Breast-feeding and diarrheal morbidity. Pediatrics 1990; 86: 874–882.PubMedGoogle Scholar
  128. 128.
    Glass RI, Stoll BJ. The protective effect of human milk against diarrhea. Acta Paediatr Scand 1989; 351: 131–136.CrossRefGoogle Scholar
  129. 129.
    Cunningham AS. Morbidity in breast-fed and artificially fed infants. J Pediatr 1977; 90: 726–769.PubMedCrossRefGoogle Scholar
  130. 130.
    Cunningham AS. Morbidity in breast-fed and artificially fed infants. II. J Pediatr 1979; 95: 685–689.CrossRefGoogle Scholar
  131. 131.
    Cunningham AS, Jelliffe DB, Jelliffe EFP. Breast-feeding and health in the 1980s: a global epidemiologic review. J Pediatr 1991; 118: 659–666.PubMedCrossRefGoogle Scholar
  132. 132.
    Dewey KG, Heinig MJ, Nommsen-Rivers LA. Differences in morbidity between breastfed and formula-fed infants. J Pediatr 1995; 126: 696–702.PubMedCrossRefGoogle Scholar
  133. 133.
    Kovar MG, Serdula MD, Marks JS, et al. Review of the epidemiologic evidence for an association between infant feeding and infant health. Pediatrics 1984; 74: S615–638.Google Scholar
  134. 134.
    Howie PW, Forsyth JS, Ogston SA, et al. Protective effect of breast-feeding against infection. Br Med J 1990; 300: 11–16.CrossRefGoogle Scholar
  135. 135.
    Frank AL, Taber LH, Glezen WP, et al. Breast-feeding and respiratory virus infection. Pediatrics 1982; 70: 239–245.PubMedGoogle Scholar
  136. 136.
    Wright AL, Holberg CJ, Martinez FD, et al. Breast feeding and lower respiratory tract illness in the first year of life. Br Med J 1989; 299: 945–948.Google Scholar
  137. 137.
    World Health Organization, United Nations Children’s Fund. Protecting, promoting and supporting breast-feeding: the special role of maternity services. Geneva, Switzerland: WHO, 1989.Google Scholar
  138. 138.
    Rubin DH, Leventhal JM, Krasilnikoff PA, et al. Relationship between infant feeding and infectious illness: a prospective study of infants during the first year of life. Pediatrics 1990; 85: 464–471.PubMedGoogle Scholar
  139. 139.
    Duncan B, Ey J, Holberg CJ, et al. Exclusive breast-feeding for at least 4 months protects against otitis media. Pediatrics 1993; 91: 867–872.PubMedGoogle Scholar
  140. 140.
    Pisacane A, Graziano L, Mazzarella G, et al. Breast-feeding and urinary tract infection. J Pediatr 1992; 120: 87–89.PubMedCrossRefGoogle Scholar
  141. 141.
    Coppa GV, Gabrielli O, Giorgi P, et al. Preliminary study of breast-feeding and bacterial adhesion to uroepithelial cells. Lancet 1990; 335: 569–571.PubMedCrossRefGoogle Scholar
  142. 142.
    Goldblum RM, Schanler RJ, Garza C, et al. Human milk feeding enhances the urinary excretion of immunologic factors in low birth weight infants. Pediatr Res 1989; 25: 184–188.PubMedCrossRefGoogle Scholar
  143. 143.
    Lucas A, Cole TJ. Breast milk and neonatal necrotizing enterocolitis. Lancet 1990; 336: 1519–1523.PubMedCrossRefGoogle Scholar
  144. 144.
    Schanler RJ, Shulman RJ, Lau C. Fortified human milk improves the health of the premature infant. Pediatr Res 1996; 40: 548A.Google Scholar
  145. 145.
    Eibl MM, Wolf HM, Furnkranz H, et al. Prevention of necrotizing enterocolitis in low-birth-weight infants by IgA-IgG feeding. N Engl J Med 1988; 319: 1–7.PubMedCrossRefGoogle Scholar
  146. 146.
    Narayanan I, Prakash K, Bala S, et al. Partial supplementation with expressed breast-milk for prevention of infection in low-birth-weight infants. Lancet 1980; 2: 561–563.PubMedCrossRefGoogle Scholar
  147. 147.
    Narayanan I, Prakash K, Gujral VV. The value of human milk in the prevention of infection in the high-risk lowbirth-weight infant. J Pediatr 1981; 99: 496–498.PubMedCrossRefGoogle Scholar
  148. 148.
    Narayanan I, Prakash K, Murthy NS, et al. Randomised controlled trial of effect of raw and holder pasteurised human milk and of formula supplements on incidence of neonatal infection. Lancet 1984; 2: 1111–1113.PubMedCrossRefGoogle Scholar
  149. 149.
    El-Mohandes AAE, Picard M, Simmens Si. Human milk utilization in the ICN decreases the incidence of bacterial sepsis. Pediatr Res 1995; 37: 306A.Google Scholar
  150. 150.
    Covert RF, Barman N, Domanico RS, et al. Prior enteral nutrition with human milk protects against intestinal perforation in infants who develop necrotizing enterocolitis. Pediatr Res 1995; 37: 305A.Google Scholar
  151. 151.
    Narayanan I, Prakash K, Verma RK, et al. Administration of colostrum for the prevention of infection in the low birth weight infant in a developing country. J Trop Pediatr 1983; 29: 197–200.PubMedCrossRefGoogle Scholar
  152. 152.
    Contreras-Lemus J, Flores-Huerta S, Cisneros-Silva I, et al. Disminucion de la morbilidad en neonatos pretermino alimentados con leche de su propia madre. Biol Med Hosp Infant Mex 1992; 49: 671–677.Google Scholar
  153. 153.
    Davis MK, Savitz DA, Graubard BI. Infant feeding and childhood cancer. Lancet 1988; 1: 365–368.CrossRefGoogle Scholar
  154. 154.
    Koletzko S, Sherman P, Corey M, et al. Role of infant feeding practices in development of Crohn’s disease in childhood. Br Med J 1989; 298: 1617–1618.CrossRefGoogle Scholar
  155. 155.
    Gerstein HC. Cow’s milk exposure and type I diabetes mellitus. Diabetes Care 1994; 17: 13–19.PubMedCrossRefGoogle Scholar
  156. 156.
    Kramer MS. Does breast feeding help protect against atopic disease? Biology, methodology, and a golden jubilee of controversy. J Pediatr 1988; 112: 181–190.PubMedCrossRefGoogle Scholar
  157. 157.
    Saarinen UM, Backman A, Kajosaari M, et al. Prolonged breast-feeding as prophylaxis for atopic disease. Lancet 1979; 2: 163–166.PubMedCrossRefGoogle Scholar
  158. 158.
    Karjalainen J, Martin JM, Knip M, et al. A bovine albumin peptide as a possible trigger of insulin-dependent diabetes mellitus. N Engl J Med 1992; 327: 302–307.PubMedCrossRefGoogle Scholar
  159. 159.
    Rogan WJ, Gladen BC. Breast-feeding and cognitive development. Early Hum Dev 1993; 31: 181–193.PubMedCrossRefGoogle Scholar
  160. 160.
    Lucas A, Morley R, Cole Ti, et al. A randomised multi-centre study of human milk versus formula and later development in preterm infants. Arch Dis Child 1994; 70: F141–146.CrossRefGoogle Scholar
  161. 161.
    Lucas A, Morley R, Cole TJ, et al. Breast milk and subsequent intelligence quotient in children born preterm. Lancet 1992; 339: 261–264.PubMedCrossRefGoogle Scholar
  162. 162.
    Crawford MA. The role of essential fatty acids in neural development: implications for perinatal nutrition. Am J Clin Nutr 1993; 57: 703S–710S.PubMedGoogle Scholar
  163. 163.
    Anderson GJ, Connor WE, Corliss JD. Docosahexaenoic acid is the preferred dietary n-3 fatty acid for the development of the brain and retina. Pediatr Res 1990; 27: 89–97.PubMedCrossRefGoogle Scholar
  164. 164.
    Riordan J. Anatomy and psychophysiology of lactation. In: Riordan J, Auerbach KG, eds. Breast-feeding and human lactation. Boston: Jones and Bartlett, 1993: 81–104.Google Scholar
  165. 165.
    Wang IY, Fraser IS. Reproductive function and contraception in the postpartum period. Obster Gynecol Sury 1994; 49: 56–63.CrossRefGoogle Scholar
  166. 166.
    Campbell OM, Gray RH. Characteristics and determinants of postpartum ovarian function in women in the United States. Am J Obstet Gynecol 1993; 169: 55–60.PubMedGoogle Scholar
  167. 167.
    Dewey KG, Heinig MJ, Nommsen LA. Maternal weight-loss patterns during prolonged lactation. Am J Clin Nutr 1993; 58: 162–166.PubMedGoogle Scholar
  168. 168.
    Ohlin A, Rossner S. Maternal body weight development after pregnancy. Int J Obes 1990; 15: 159–173.Google Scholar
  169. 169.
    Greene GW, Smicklas-Weight H, School TO, et al. Postpartum weight change: How much of the weight gained in pregnancy will be lost after delivery? Obstet Gynecol 1988; 71: 701–717.PubMedGoogle Scholar
  170. 170.
    Rookus MA, Rokebrand P, Burema J, et al. The effect of pregnancy on the body mass index 9 months postpartum in 49 women. Int J Obes 1987; 11: 609–618.PubMedGoogle Scholar
  171. 171.
    Potter S, Hannum S, McFarlin B, et al. Does infant feeding method influence maternal weight loss? J Am Diet Assoc 1991; 91: 441–446.PubMedGoogle Scholar
  172. 172.
    Dugdale AE, Eaton-Evans J. The effect of lactation and other factors on post-partum changes in body-weight and triceps skinfold thickness. Br J Nutr 1989; 61: 149–153.PubMedCrossRefGoogle Scholar
  173. 173.
    Manning-Dalton C, Allen LH. The effects of lactation on energy and protein consumption, postpartum weight change and body composition of well nourished North American women. Nutr Res 1983; 3: 293–308.CrossRefGoogle Scholar
  174. 174.
    Kent GN, Price RI, Gutteridge DH, et al. Human lactation: forearm trabecular bone loss, increased bone turnover, and renal conservation of calcium and inorganic phosphate with recovery of bone mass following weaning. J Bone Min Res 1990; 5: 361–369.CrossRefGoogle Scholar
  175. 175.
    Lamke B, Brundin J, Moberg P. Changes in bone mineral content during pregnancy and lactation. Acta Obstet Gynecol Scand 1977; 56: 217–219.PubMedCrossRefGoogle Scholar
  176. 176.
    Specker BL, Tsang RC, Ho ML. Changes in calcium homeostasis over the first year postpartum: effect of lactation and weaning. Obstet Gynecol 1991; 78: 56–62.PubMedGoogle Scholar
  177. 177.
    Sowers MF, Corton G, Shapiro B, et al. Changes in bone density with lactation. JAMA 1993; 269: 3130–3135.PubMedCrossRefGoogle Scholar
  178. 178.
    Aloia JF, Cohn SH, Vaswani A, et al. Risk factors for postmenopausal osteoporosis. Am J Med 1985; 78: 95–100.PubMedCrossRefGoogle Scholar
  179. 179.
    Feldblum PJ, Zhang J, Rich LE, et al. Lactation history and bone mineral density among perimenopausal women. Epidemiology 1992; 3: 527–531.PubMedCrossRefGoogle Scholar
  180. 180.
    Kreiger N, Kelsey JL, Holford TR, et al. An epidemiologic study of hip fracture in postmenopausal women. Epidemiology 1982; 116: 141–148.Google Scholar
  181. 181.
    Cumming RG, Klineberg RJ. Breast-feeding and other reproductive factors and the risk of hip fracture in elderly women. Int J Epidemiol 1993; 2: 684–691.CrossRefGoogle Scholar
  182. 182.
    Bauer DC, Browner WS, Cauley JA, et al. Factors associated with appendicular bone mass in older women. Ann Intern Med 1993; 118: 657–665.PubMedGoogle Scholar
  183. 183.
    Fox KM, Magaziner J, Sherwin R, et al. Reproductive correlates of bone mass in elderly women. J Bone Miner Res 1993; 8: 901–908.PubMedCrossRefGoogle Scholar
  184. 184.
    Kritz-Silverstein D, Barett-Connor E, Hollenbach KA. Pregnancy and lactation as determinants of bone mineral density in postmenopausal women. Am J Epidemio1 1992; 136: 1052–1059.PubMedGoogle Scholar
  185. 185.
    Byers TS, Graham S, Rzepka T, et al. Lactation and breast cancer: evidence for a negative association in premenopausal women. Am J Epidemiol 1985; 121: 664–674.PubMedCrossRefGoogle Scholar
  186. 186.
    Layde PM, Webster LA, Baughman AL, et al. The independent associations of parity, age at first full term pregnancy, and duration of breast-feeding with the risk of breast cancer. Cancer and Steroid Hormone Study Group. J Clin Epidemiol 1989; 42: 963–973.PubMedCrossRefGoogle Scholar
  187. 187.
    McTiernan A, Thomas DB. Evidence for a protective effect of lactation on risk of breast cancer in young women: results from a case control study. Am J Epidemiol 1986; 124: 353–358.PubMedGoogle Scholar
  188. 188.
    Yoo K, Tajima K, Kuroishi T, et al. Independent protective effect of lactation against breast cancer: a case control study in Japan. Am J Epidemiol 1992; 135: 726–733.PubMedGoogle Scholar
  189. 189.
    Newcomb PA, Storer BE, Longnecker MP, et al. Lactation and a reduced risk of premenopausal breast cancer. N Engl J Med 1994; 330: 81–87.PubMedCrossRefGoogle Scholar
  190. 190.
    Kvale G, Heuch I. Lactation and cancer risk: Is there a relation specific to breast cancer? J Epidemiol Community Health 1987; 42: 30–37.CrossRefGoogle Scholar
  191. 191.
    Wynder EL, MacCornack FA, Stellman SD, The epidemiology of breast cancer in 785 United States Caucasian women. Cancer 1978; 41: 2341–2354.PubMedCrossRefGoogle Scholar
  192. 192.
    Brinton LA, Hoover R, Fraumeni JF. Reproductive factors in the aetiology of breast cancer. Br J Cancer 1983; 47: 757–762.PubMedCrossRefGoogle Scholar
  193. 193.
    London SJ, Colditz GA, Stampfer MJ, et al. Lactation and risk of breast cancer in a cohort of US women. Am J Epidemiol 1990; 132: 17–26.PubMedGoogle Scholar
  194. 194.
    Siskind V, Schofield F, Rice D, et al. Breast cancer and breast-feeding: results from an Australian case-control study. Am J Epidemiol 1989; 130: 229–236.PubMedGoogle Scholar
  195. 195.
    Thomas DB, Noonan EA. Breast cancer and prolonged lactation. The WHO Collaborative Study of Neoplasia and Steroid Contraceptives. Int J Epidemiol 1993; 22: 619–626.PubMedCrossRefGoogle Scholar
  196. 196.
    Lawrence RA. Early discharge alert. Pediatrics 1995; 96: 966–967.PubMedGoogle Scholar
  197. 197.
    Neifert M. Early assessment of the breast-feeding infant. Contemp Pediatr 1996; 13 (10): 142–166.Google Scholar
  198. 198.
    Powers NG, Naylor AJ, Wester RA. Hospital policies: crucial to breast-feeding success. Semin Perinatol 1994; 18: 517–524.PubMedGoogle Scholar
  199. 199.
    World Health Organization, UNICEF, Protecting, promoting, and supporting breastfeeding: the special role of maternity services. Geneva, Switzerland: World Health Organization, 1989.Google Scholar
  200. 200.
    UNICEF. Innocenti declaration on the protection, promotion, and support of breast-feeding. New York: UNICEF, Nutrition Cluster (H-8F), 1990.Google Scholar
  201. 201.
    UNICEF. Take the Baby-Friendly Hospital Initiative! A global effort with hospitals, health services, and parents to breast-feed babies for the best start in life. New York: UNICEF, 1991.Google Scholar
  202. 202.
    Wright A, Rice S, Wells S. Changing hospital practices to increase the duration of breast-feeding. Pediatr 1996; 97: 669–675.Google Scholar
  203. 203.
    DeCarvalho M, Hall M, Harvey D. Effects of water supplementation on physiological jaundice in breast-fed babies. Arch Dis Child 1981; 56: 568–569.CrossRefGoogle Scholar
  204. 204.
    Bachrach S, Fisher J, Parks JS. An outbreak of vitamin D deficiency rickets in a susceptible population. Pediatrics 1979; 64: 871–877.PubMedGoogle Scholar
  205. 205.
    Roberts CC, Chan GM, Folland D, et al. Adequate bone mineralization in breast-fed infants. J Pediatr 1981; 99: 192–196.PubMedCrossRefGoogle Scholar
  206. 206.
    U.S. Department of Health Education and Welfare. National Center For Health Statistics (NCHS) growth curves for children, birth-18 years. Publication No. (PHS) 781650. Washington, DC: DHEW, 1977.Google Scholar
  207. 207.
    Ahn CH, MacLean WC. Growth of the exclusively breast-fed infant. Am J Clin Nutr 1980; 33: 183–192.PubMedGoogle Scholar
  208. 208.
    Dewey KG, Heinig MJ, Nommsen LA, et al. Growth of breast-fed and formula-fed infants from 0 to 18 months: the DARLING study. Pediatrics 1992; 89: 1035–1041.PubMedGoogle Scholar
  209. 209.
    Nelson SE, Rogers RR, Ziegler EE, et al. Gain in weight and length during early infancy. Early Hum Dev 1989; 19: 223–239.PubMedCrossRefGoogle Scholar
  210. 210.
    Salmenpera L, Perheentupa J, Siimes MA. Exclusively breast-fed healthy infants grow slower than reference infants. Pediatr Res 1985; 19: 307–312.PubMedCrossRefGoogle Scholar
  211. 211.
    Whitehead RG, Paul AA, Cole TJ. Diet and the growth of healthy infants. J Hum Nutr Diet 1989; 2: 73–84.CrossRefGoogle Scholar
  212. 212.
    Heinig MJ, Nommsen LA, Peerson JM, et al. Intake and growth of breast-fed and formula-fed infants in relation to the timing of introduction of complementary foods: the DARLING study. Acta Paediatr 1993; 82: 999–1006.PubMedCrossRefGoogle Scholar
  213. 213.
    De Curtis M, Brooke OG. Energy and nitrogen balances in very low birthweight infants. Arch Dis Child 1987; 62: 830–832.PubMedCrossRefGoogle Scholar
  214. 214.
    Brooke OG, Onubogu O, Heath R, et al. Human milk and preterm formula compared for effects on growth and metabolism. Arch Dis Child 1987; 62: 917–923.PubMedCrossRefGoogle Scholar
  215. 215.
    Kashyap S, Schulze KF, Forsyth M, et al. Growth, nutrient retention, and metabolic response of low-birth-weight infants fed supplemented and unsupplemented preterm human milk Am J Clin Nutr 1990; 52: 254–262.Google Scholar
  216. 216.
    Cooper PA, Rothberg AD, Pettifor JM, et al. Growth and biochemical response of premature infants fed pooled preterm milk or special formula. J Pediatr Gastroenterol Nutr 1984; 3: 749–754.PubMedCrossRefGoogle Scholar
  217. 217.
    Gross SJ. Growth and biochemical response of preterm infants fed human milk or modified infant formula. N Engl J Med 1983; 308: 237–241.PubMedCrossRefGoogle Scholar
  218. 218.
    Atkinson SA, Bryan MH, Anderson GH. Human milk feeding in premature infants: protein, fat and carbohydrate balances in the first two weeks of life. J Pediatr 1981; 99: 617–624.PubMedCrossRefGoogle Scholar
  219. 219.
    Schanler RJ, Oh W. Nitrogen and mineral balance in preterm infants fed human milks or formula. J Pediatr Gastroenterol Nutr 1985; 4: 214–219.PubMedCrossRefGoogle Scholar
  220. 220.
    Bates CJ, Liu DS, Fuller NJ, et al. Susceptibility of riboflavin and vitamin A in breast milk to photodegradation and its implications for the use of banked breast milk in infant feeding. Acta Paediatr Scand 1985; 74: 40–44.PubMedCrossRefGoogle Scholar
  221. 221.
    Rowe JC, Wood DH, Rowe DW, et al. Nutritional hypophosphatemic rickets in a premature infant fed breast milk. N Engl J Med 1979; 300: 293–296.PubMedCrossRefGoogle Scholar
  222. 222.
    Atkinson SA, Radde IC, Anderson GH. Macromineral balances in premature infants fed their own mothers’ milk or formula. J Pediatr 1983; 102: 99–106.PubMedCrossRefGoogle Scholar
  223. 223.
    Raiha NCR, Heinonen K, Rassin DK, et al. Milk protein quantity and quality in low-birth-weight infants. I. Metabolic responses and effects on growth. Pediatrics 1976; 57: 659–674.PubMedGoogle Scholar
  224. 224.
    Ronnholm KAR, Sipila I, Siimes MA. Human milk protein supplementation for the prevention of hypoproteinemia without metabolic imbalance in breast milk-fed, very low birth weight infants. J Pediatr 1982; 101: 243–247.PubMedCrossRefGoogle Scholar
  225. 225.
    Polberger SKT, Axelsson IE, Räihä NCR. Urinary and serum urea as indicators of protein metabolism in very low birthweight infants fed varying human milk protein intakes. Acta Paediatr Scand 1990; 79: 737–742.PubMedCrossRefGoogle Scholar
  226. 226.
    Roy RN, Chance GW, Radde IC, et al. Late hyponatremia in very low birthweight infants. Pediatr Res 1976: 526–531.Google Scholar
  227. 227.
    Kumar SP, Sacks LM. Hyponatremia in very low-birthweight infants and human milk feedings. J Pediatr 1978; 93: 1026–1027.PubMedCrossRefGoogle Scholar
  228. 228.
    Schanler RJ. Calcium and phosphorus absorption and retention in preterm infants. Exp Med 1991; 2: 24–36.Google Scholar
  229. 229.
    Ziegler EE, O’Donnell AM, Nelson SE, et al. Body composition of the reference fetus. Growth 1976; 40: 329–341.PubMedGoogle Scholar
  230. 230.
    American Academy of Pediatrics, Committee on Nutrition. Nutritional needs of low-birth-weight infants. Pediatrics 1985; 75: 976–986.Google Scholar
  231. 231.
    Koo WWK, Sherman R, Succop P, et al. Sequential bone mineral content in small preterm infants with and without fractures and rickets. J Bone Miner Res 1988; 3: 193–197.PubMedCrossRefGoogle Scholar
  232. 232.
    Pettifor JM, Stein H, Herman A. Mineral homeostasis in very low birth weight infants fed either own mother’s milk or pooled pasteurized preterm milk. J Pediatr Gastroenterol Nutr 1986; 5: 248–253.PubMedGoogle Scholar
  233. 233.
    Lucas A, Brooke OG, Baker BA, et al. High alkaline phosphatase activity and growth in preterm neonates. Arch Dis Child 1989; 64: 902–909.PubMedCrossRefGoogle Scholar
  234. 234.
    Senterre J, Putet G, Salle B, et al. Effects of vitamin D and phosphorus supplementation on calcium retention in pre-term infants fed banked human milk. J Pediatr 1983; 103: 305–307.PubMedCrossRefGoogle Scholar
  235. 235.
    Heinonen K, Mononen I, Mononen T, et al. Plasma vitamin C levels are low in premature infants fed human milk. Am J Clin Nutr 1986; 43: 923–924.PubMedGoogle Scholar
  236. 236.
    Stein H, Cohen D, Herman AAB. Pooled pasteurized breast milk and untreated own mother’s milk in the feeding of very low birth weight babies: a randomized controlled trial. J Pediatr Gastroenterol Nutr 1986; 5: 242–247.PubMedGoogle Scholar
  237. 237.
    Garza C. Banked human milk for very low birth weight infants. In: Atkinson SA, Hanson LA, Chandra RK, eds. Breast-feeding, nutrition, infection and infant growth in developed and emerging countries. St. John’s, Newfoundland, Canada: ARTS Biomedical, 1990: 25–34.Google Scholar
  238. 238.
    Bhatia J, Rassin DK. Human milk supplementation: delivery of energy, calcium, phosphorus, magnesium, copper and zinc. Am J Dis Child 1988; 142: 445–447.PubMedGoogle Scholar
  239. 239.
    Hall B. Uniformity of human milk. Am J Clin Nutr 1979; 32: 304–312.PubMedGoogle Scholar
  240. 240.
    Moro GE, Fulconis F, Minoli I, et al. Growth and plasma amino acid concentrations in very low birthweight infants fed either human milk, protein fortified human milk or whey-predominant formula. Acta Paediatr Scand 1989; 78: 18–22.PubMedCrossRefGoogle Scholar
  241. 241.
    Polberger SKT, Axelsson IA, Raiha NCR. Growth of very low birth weight infants on varying amounts of human milk protein. Pediatr Res 1989; 25: 414–419.PubMedCrossRefGoogle Scholar
  242. 242.
    Ronnholm KAR, Perheentupa J, Siimes MA. Supplementation with human milk protein improves growth of small premature infants fed human milk. Pediatrics 1986; 77: 649–653.PubMedGoogle Scholar
  243. 243.
    Putet G, Rigo J, Salle B, et al. Supplementation of pooled human milk with casein hydrolysate: energy and nitrogen balance and weight gain composition in very low birth weight infants. Pediatr Res 1987; 21: 458–461.PubMedCrossRefGoogle Scholar
  244. 244.
    Schanler RJ, Garza C. Improved mineral balance in very low birth weight infants fed fortified human milk. J Pediatr 1987; 112: 452–456.Google Scholar
  245. 245.
    Greer FR, McCormick A. Improved bone mineralization and growth in premature infants fed fortified own mother’s milk. J Pediatr 1988; 112: 961–969.PubMedCrossRefGoogle Scholar
  246. 246.
    Nutritional Support of the Neonate II 1199Google Scholar
  247. 247.
    Ehrenkranz RA, Gettner PA, Nelli CM. Nutrient balance studies in premature infants fed premature formula or fortified preterm human milk. J Pediatr Gastroenterol Nutr 1989; 8: 58–67.PubMedCrossRefGoogle Scholar
  248. 248.
    Schanler RJ, Abrams SA. Postnatal attainment of intrauterine macromineral accretion rates in low birth weight infants fed fortified human milk J Pediatr 1995; 126: 441–447.Google Scholar
  249. 249.
    Schanler RJ, Burns PA, Abrams SA, et al. Bone mineralization outcomes in human milk-fed preterm infants. Pediatr Res 1992; 31: 583–586.PubMedCrossRefGoogle Scholar
  250. 250.
    Rifka MG, Schanler RJ. Can we meet intrauterine calcium (Ca) and phosphorus (P) accretion rates by feeding very low birth weight infants (VLBWI) fortified human milk? Pediatr Res 1994; 35: 319A.Google Scholar
  251. 251.
    Arnold LDW. Recommendations for collection, storage, and handling of a mother’s milk for her own infant in the hospital setting. West Hartford, CT: Human Milk Banking Association of North America, 1993.Google Scholar
  252. 252.
    Zinaman MJ, Hughes V, Queenan JT, et al. Acute prolactin and oxytocin responses and milk yield to infant suckling and artificial methods of expression in lactating women. Pediatrics 1992; 89: 437–440.PubMedGoogle Scholar
  253. 253.
    Auerbach KG. Sequential and simultaneous breast pumping: a comparison. Int J Nurs Stud 1990; 27: 257–265.PubMedCrossRefGoogle Scholar
  254. 254.
    Lefebvre F, Ducharme M. Incidence and duration of lactation and lactational performance among mothers of low-birth-weight and term infants. Can Med Assoc J 1989; 140: 1159–1164.Google Scholar
  255. 255.
    DeCarvalho M, Robertson S, Friedman A, et al. Effect of frequent breast-feeding on early milk production and infant weight gain. Pediatrics 1983; 72: 307–311.Google Scholar
  256. 256.
    Miles MS. Parents of critically ill premature infants: sources of stress. Crit Care Nurs Q 1989: 69–74.Google Scholar
  257. 257.
    Cross BA. Neurohormonal mechanisms in emotional inhibition of milk ejection. J Endocrinol 1977; 41: 193–210.Google Scholar
  258. 258.
    Whitelaw A, Sleath K. Myth of the marsupial mother: home care of very low birthweight babies in Bogota, Colombia. Lancet 1985; 2: 1206–1209.CrossRefGoogle Scholar
  259. 259.
    DeLeeuw R, Colin EM, Dunnebier EA, et al. Physiological effects of kangaroo care in very small preterm infants. Biol Neonate 1991; 59: 149–155.CrossRefGoogle Scholar
  260. 260.
    Wahlberg V. Alternative care for premature infants. The “kangaroo method. ” Advantages, risks, and ethical questions. Neonatologica 1987; 4: 362–367.Google Scholar
  261. 261.
    Acolet D, Sleath K, Whitelaw A. Oxygenation, heart rate and temperature in very low birth infants during skin-toskin contact with their mothers. Acta Paediatr Scand 1989; 78: 189–193.PubMedCrossRefGoogle Scholar
  262. 262.
    McCormick DB. Water-soluble vitamins: bases for suggested upper limits for infant formulas. J Nutr 1989; 119: 1818–1819.PubMedGoogle Scholar
  263. 263.
    Coward WA. Measuring milk intake in breast-fed babies. J Pediatr Gastroenterol Nutr 1984; 3: 275–279.PubMedCrossRefGoogle Scholar
  264. 264.
    American Academy of Pediatrics, Committee on Nutrition. Zinc. Pediatrics 1978; 62: 408–412.Google Scholar
  265. 265.
    Blanc B. Biochemical aspects of human milk-comparison with bovine milk. World Rev Nutr Diet 1981; 36: 1–89.PubMedGoogle Scholar
  266. 266.
    Dallman PR. Nutritional anemia in infancy: iron, folic acid, and vitamin B12. In: Tsang RC, Nichols BL, eds. Nutrition during infancy. Philadelphia: Hanley & Belfus, 1988: 216–235.Google Scholar
  267. 267.
    Schanler RJ. Water soluble vitamins: C, B,, B2, B6, niacin, biotin, and pantothenic acid. In: Tsang RC, Nichols BL, eds. Nutrition during infancy. Philadelphia: Hanley & Belfus, 1988: 236–252.Google Scholar
  268. 268.
    Newman V. Vitamin A and breast-feeding: a comparison of data from developed and developing countries. Food Nutr Bull 1994; 15: 161–176.Google Scholar

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© Springer Science+Business Media New York 1998

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  • Richard J. Schanler

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