Lipid Metabolism in Pregnancy

  • Robert H. Knopp
  • Bartolome Bonet
  • Xiaodong Zhu


It is not a new idea that lipid metabolism is altered during pregnancy. Virchowl and Becquerel and Rodier2 observed lipemia during pregnancy in the 19th century and concluded that it represented an elevation in plasma lipids. It is also an old observation that certain fatty acids are essential in the diet, and it follows that the mother must supply these fatty acids to the fetus.3 What is new is the understanding of how maternal lipid metabolism adapts to the needs of fetal growth and development and how derangements in lipid metabolism can impair fetal growth and development. This knowledge has been spurred by the expansion of our understanding of lipoprotein physiology, and the awareness that lipoprotein lipid lowering can prevent arterial wall injury 4,5 This chapter describes what is known about alterations in lipid and lipoprotein metabolism in pregnancy and the ways in which altered lipid metabolism in pregnancy may affect fetal growth and development.


Cholesterol Ester Transfer Protein Lipoprotein Lipid Plasma Triglyceride Concentration Triglyceride Fatty Acid Fractional Catabolic Rate 
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Copyright information

© Springer Science+Business Media New York 1998

Authors and Affiliations

  • Robert H. Knopp
  • Bartolome Bonet
  • Xiaodong Zhu

There are no affiliations available

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