The Cell Cycle and Neuronal Cell Death

  • Robert S. Freeman

Abstract

Birth and death, the extremes of life, conjure images of antithetic and counteracting events necessary for maintaining a balance among living organisms. Their cellular counterparts, cell division and cell death, work in similar opposition to ensure proper development of an organism and to maintain homeostasis and normal function. A breakdown of either process can be detrimental and, in humans, may lead to birth defects, cancer, autoimmune disease, and neurological disorders. Although researchers have been well aware of the importance of proper cell division for decades, only recently has the significance of cell death attracted widespread appreciation. Consequently, we now have a relatively sophisticated understanding of the machinery that controls cell division; in comparison, we have only a rudimentary knowledge of the mechanisms that underlie cell death. But surprisingly, given our inclination to categorize birth and death as opposing and distinct forces, much of what we currently know about cell death has been fueled by research into cell cycle control. In this chapter, the hypothesis that the control of cell death and the cell cycle overlap will be discussed.

Keywords

Retina Caffeine Beach Glucocorticoid Osteosarcoma 

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© Springer Science+Business Media New York 1999

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  • Robert S. Freeman

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