Molecular Mechanisms Regulating Uterine Decidualization and Implantation: Cell—Cell and Cell—Extracellular Matrix Interactions

  • Virginia Rider
Part of the Proceedings in the Serono Symposia USA Series book series (SERONOSYMP)


Implantation of the mammalian embryo and development of the placenta are interactive processes that depend on two-way communication between genetically distinct individuals. Since the pioneering embryo transfer experiments of Chang (1), the importance of developmental synchrony between the uterus and embryo for successful implantation has been appreciated. Although the strictness of this relationship varies somewhat among species, some degree of maturity of both the embryo and the uterus is required for the initiation of implantation. An important correlate of uterine maturation in many species, including the human, is the proliferation and differentiation of uterine stromal cells just before implantation. This process is called decidualization. Decidualization is initiated prior to breachment of the basement membrane by the blastocyst, and decidual cells are in intimate contact with the embryo during its implantation into the uterine wall. As a normal part of placentation, some decidual cells subsequently undergo apoptosis to accommodate the growing conceptus.


Stromal Cell Progesterone Receptor Fibroblast Growth Factor Receptor Basic Fibroblast Growth Factor Embryo Implantation 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media New York 1999

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  • Virginia Rider

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