Abstract
During no other time in postnatal human development are there such massive changes in body composition as in puberty. GH and IGF-I production are greatly enhanced, and insulin and sex steroidal hormones increase during this period, allowing the child’s transformation into a fully grown adult with reproductive maturity. Some of the changes observed are directly related to the enhancement of whole-body protein synthetic rates and the increase of specific protein pools as well as to the increased calcium absorption and retention, leading to increased bone mineralization, net bone accrual, and eventual achievement of peak bone mass. Safe and reproducible investigative techniques are now available that permit the assessment of protein, calcium, and glucose kinetics, as well as body compositional changes. These tools are uniquely useful in human studies, particularly pediatric studies, as they do not involve radioactive materials, and are relatively noninvasive and nontoxic. We have studied the relative contributions of these anabolic hormones to the metabolic changes of puberty and assessed the effects of these hormones in chronic catabolic states.
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Referencess
Wolfe RR. Calculation of substrate kinetics: single-pool model. In: Wolfe RR, ed. Radioactive and stable isotope tracers in biomedicine. New York: Wiley-Liss, 1992: 119–44.
Steele R. Influences of glucose loading and of injected insulin on hepatic glucose output. Ann NY Acad Sci 1959;82:420–30.
Horber FF, Haymond MW. Human growth hormone prevents the protein catabolic side effects of prednisone in humans. J Clin Invest 1990;86:265–72.
Schwenk WF, Beaufrere B, Haymond MW. Use of reciprocal pool specific activities to model leucine metabolism in humans. Am J Physiol 1985;249:E646–50.
DeFeo P, Gaisano MG, Haymond MW. Differential effects of insulin deficiency on albumin and fibrinogen synthesis in humans. J Clin Invest 1991;88:833–40.
Fu AZ, Morris JC, Ford GC, Nair KS. Sequential purification of human apolipoprotein B-100, albumin, and fibrinogen by immunoaffinity chromatogra-phy for measurement of protein synthesis. Anal Biochem 1997;247:228–36.
Balagopal P, Rooyackers OE, Adey DB, Ades PA, Nair KS. Effects of aging on in vivo synthesis of skeletal muscle myosin heavy-chain and sarcoplasmic protein in humans. Am J Physiol 1997;273:E790–800.
Bier DM, Leake RD, Haymond MW, Arnold KJ, Bruenke LD, Sperling MA, Kipnis DM. Measurement of “true” glucose production rates in infancy and childhood with 6,6-dideuteroglucose. Diabetes 1997;26:1016–23.
Yergey AL, Abrams SA, Vieria NE, Eastell R, Hillman LS, Covell DG. Recent studies of human calcium metabolism using stable isotope tracers. Can J Physiol Pharmacol 1990;68:973–6.
Neer R, Berman N, Fisher L, Rosenberg R. Multicompartmental analysis of calcium kinetics in normal adult males. J Clin Invest 1967;46:1364—79.
Berman M, Weissberger AJ. SAAM manual (simulation, analysis and modeling). DHEW Publ 78–180. Bethesda: National Institutes of Health, 1990.
Saenger P, Attie KM, Dimartino-Nardi J, Hintz R, Frahm L, Frane JW. Metabolic consequences of 5-year growth hormone (GH) therapy in children treated with GH for idiopathic short stature. Genentech Collaborative Study Group. J Clin Endocrinol Metab 1998; 83:3115–20.
Zenobi PD, Jaeggi-Groisman SE, Riesen WF, Roder ME, Froesch ER. Insulin-like growth factor I improves glucose and lipid metabolism in type 2 diabetes mellitus. J Clin Invest 1992;90:2234–41.
Guler HP, Zapf J, Froesch ER. Short-term metabolic effects of recombinant human insulin-like growth factor I in healthy adults. N Engl J Med 1987;317:137–40.
Mauras N, Beaufrere B. Recombinant human IGF-I enhances whole body protein anabolism and significantly diminishes the protein-catabolic effects of prednisone in humans, without a diabetogenic effect. J Clin Endocrinol Metab 1995;80: 869–74.
Fukagawa NK, Minaker KL, Rowe JW, Goodman MN, Matthews DE, Bier DM, Young VR. Insulin-mediated reduction of whole body protein breakdown. Dose-response effects on leucine metabolism in post-absorptive men. J Clin Invest 1985;76:2306-ll.
Kupfer SR, Underwood LE, Baxter RC, Clemmons DR. Enhancement of the anabolic effects of growth hormone and insulin-like growth factor I by use of both agents simultaneously. J Clin Invest 1993;91:391–6.
Mauras N. Combined recombinant human growth hormone and recombinant human insulin-like growth factor I: lack of synergy on whole body protein anabolism in normally fed subjects. J Clin Endocrinol Metab 1995;80:2633–7.
Zapf J, Schoenle E, Waldrogel M, Sand I, Froesch ER. Effect of trypsin treatment on rat adipocytes on biological effects and binding of insulin and IGFs: further evidence for the action of IGFs through the insulin receptor. Eur J Biochem 1981;113:605–9.
Turkalj I, Keller U, Ninnis R, Vosmeer S, Stauffacher W. Effect of increasing doses of recombinant human insulin-like growth factor I on glucose, lipid, and leucine metabolism in man. J Clin Endocrinol Metab 1992;75:1186–91.
Mauras N, Martha PM, Quarmby V, Haymond MW. Recombinant human IGF-I administration in man: Differential sensitivity to the metabolic effects of subcutaneous (SC) bolus vs. continuous delivery. Am J Physiol 1997;272E349–55.
Mauras N, Haymond MW, Darmaun D, Vieira NE, Abrams SA, Yergey AL. Calcium, and protein kinetics in prepubertal boys. Positive effects of testosterone. J Clin Invest 1994;93:1014–9.
Mauras N, Hayes V, Welch S, Rini A, Helgeson K, Dokler M, Veldhuis JD, Urban R. Testosterone deficiency in young men: marked alterations in whole body protein kinetics, strength and adiposity. J Clin Endocrinol Metab 1998;83:1886–92.
Mauras N. Additive effects of GH and testosterone on the anabolic changes of puberty: a metabolic study. Pediatr Res 1998;43(abstract #459).
Mauras N, Hayes V, Yergey AL. Profound hypogonadism has significant negative effects on calcium balance in males: a calcium kinetic study. In: Proceedings, 80th Annual Meeting Endocrine Society 1998:3(abstract #88).
Mauras N. Estrogens do not affect whole-body protein metabolism in the prepubertal female. J Clin Endocrinol Metab 1985;80:2842–5.
Mauras N, Vieira NE, Yergey AL. Estrogen therapy enhances calcium absorption and retention and diminishes bone turnover in young girls with Turner’s syndrome: a calcium kinetic study. Metabolism 1997;46:908–13.
Mora S, Weber G, Guameri MP, Nizzoi G, Pasolini D, Chiumello G. Effect of estrogen replacement therapy on bone mineral content in girls with Turner’s syndrome. ObstGynecol 1992;79:747–51.
Klein KO, Baron J, Colli MJ, McDonnell DP, Cutler GB. Estrogen levels in childhood determined by an ultrasensitive recombinant cell bioassay. J Clin Invest 1994;94:2475–80.
Abrams SA, Schanler RJ, Yergey AL, Vieira NE, Bronner F. Compartmental analysis of calcium metabolism in very low-birth-weight infants. Pediatr Res 1994;36:424–8.
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Mauras, N. (1999). Metabolic Effects of GH/IGF-I, Testosterone, and Estrogen: Studies in Children and Adults. In: Veldhuis, J.D., Giustina, A. (eds) Sex-Steroid Interactions with Growth Hormone. Proceedings in the Serono Symposia USA Series. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1546-2_30
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DOI: https://doi.org/10.1007/978-1-4612-1546-2_30
Publisher Name: Springer, New York, NY
Print ISBN: 978-0-387-98810-8
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