Genetic and Transgenic Models to Investigate the Growth Hormone Axis and Sexual Dimorphism

  • Lawrence A. Frohman
  • Rhonda D. Kineman
Part of the Proceedings in the Serono Symposia USA Series book series (SERONOSYMP)


Investigation of the role of the GH axis in sexually dimorphic function requires model systems in which the axis can be perturbed in the absence of confounding changes in other pituitary and target organ hormones. The classical paradigm of ablation of an endocrine gland with subsequent replacement of the affected hormone cannot be applied to the pituitary, because the loss of other pituitary hormones confounds the interpretation of the observed changes.


Growth Hormone Sexual Dimorphism Growth Hormone Deficiency Growth Hormone Response Growth Hormone Gene 
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© Springer Science+Business Media New York 1999

Authors and Affiliations

  • Lawrence A. Frohman
  • Rhonda D. Kineman

There are no affiliations available

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