Oligopeptides That Are Anticancer Drugs

  • Anne-Marie Sapse

Abstract

The peptidic bond is present in some molecules that have been found to possess anticancer activity. These oligopeptides have been termed “lexitropsins” or information-reading molecules. They are also antibiotics, and evidence from biochemical pharmacology indicates that they act to block the template function of DNA. They do so by binding selectively to adenine-thymine (AT) sequences in the minor groove (1).

Keywords

Pyrrole Guanine Guanidinium Thymine Thiazole 

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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Anne-Marie Sapse
    • 1
    • 2
  1. 1.John Jay College and Graduate SchoolCity University of New YorkNew YorkUSA
  2. 2.Rockefeller UniversityNew YorkUSA

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