Nitrergic Neurotransmission in the Lower Urinary Tract and Penile Erectile Tissues

  • Karl-Erik Andersson
Part of the Nitric Oxide in Biology and Medicine book series (NOBM, volume 2)


Nonadrenergic, noncholinergic (NANC) nerves and neurotransmission can be demonstrated both in the lower urinary tract and in penile erectile tissues (Andersson, 1993; Andersson and Wagner, 1995). Many of the inhibitory NANC-mediated responses have been reported to involve nitric oxide (NO), but with the exception of the role of NO in penile erection, their functional importance has not been clarified. However, the demonstration of inhibitory NANC neurotransmission in normal, as well as pathophysiologically changed, lower urinary tract smooth muscles, suggests that NO may have a role physiologically and in different disorders of the lower urinary tract.


Nitric Oxide Lower Urinary Tract Interstitial Cystitis Corpus Cavernosum Penile Erection 
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