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Nitric Oxide Toxicity in Neuronal Injury and Degeneration

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Book cover Nitric Oxide and Free Radicals in Peripheral Neurotransmission

Part of the book series: Nitric Oxide in Biology and Medicine ((NOBM,volume 2))

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Abstract

The aim of this chapter is to analyze growing evidence suggesting that the interaction between oxidative stress, nitric oxide (NO), and peroxynitrite has a role in the induction of motor neuron death during development, after injury, and in pathological conditions such as amyotrophic lateral sclerosis (ALS). We also speculate about the mechanisms of motor neuron death induced by ALS mutant superoxide dismutases (SOD).

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Authors
  1. Alvaro G. Estévez
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  2. Liliana Viera
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  3. Andrés Kamaid
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  4. Joseph S. Beckman
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Editors and Affiliations

  1. Department of Physiology and Pharmacology The Sophie Davis School of Biomedical Education, City University of New York Medical School, New York, NY, 10031, USA

    Stanley Kalsner Ph.D.

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Estévez, A.G., Viera, L., Kamaid, A., Beckman, J.S. (2000). Nitric Oxide Toxicity in Neuronal Injury and Degeneration. In: Kalsner, S. (eds) Nitric Oxide and Free Radicals in Peripheral Neurotransmission. Nitric Oxide in Biology and Medicine, vol 2. Birkhäuser, Boston, MA. https://doi.org/10.1007/978-1-4612-1328-4_12

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  • DOI: https://doi.org/10.1007/978-1-4612-1328-4_12

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