NO Effect on Penile Blood Flow and Lower Genitourinary Tract Function
Nitric oxide (NO) is an unstable radical that exists primarily as a gas. For decades, NO was thought to be an environmental contaminant. Highly toxic, it was considered an unlikely candidate as a biological mediator. However, a landmark article by Furchgott and Zawadzki in 1980 described the release of a substance by the endothelial lining of blood vessels that was responsible for the vasorelaxation of smooth muscle in response to acetylcholine. They named this novel molecule endothelium-derived relaxing factor (EDRF). Since that time, most authorities have concluded that EDRF is NO (Ignarro et al. 1987; Palmer et al. 1987), however some researchers postulate that EDRF is actually an S-nitrosothiol that acts through NO transfer (Meyers et a1. 1990).
KeywordsMorphine Adduct Histamine Acetylcholine PGE1
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