NO Effect on Penile Blood Flow and Lower Genitourinary Tract Function

  • Trinity J. Bivalacqua
  • Hunter C. Champion
  • Philip J. Kadowitz
  • Wayne J. G. Hellstrom
Part of the Nitric Oxide in Biology and Medicine book series (NOBM, volume 1)


Nitric oxide (NO) is an unstable radical that exists primarily as a gas. For decades, NO was thought to be an environmental contaminant. Highly toxic, it was considered an unlikely candidate as a biological mediator. However, a landmark article by Furchgott and Zawadzki in 1980 described the release of a substance by the endothelial lining of blood vessels that was responsible for the vasorelaxation of smooth muscle in response to acetylcholine. They named this novel molecule endothelium-derived relaxing factor (EDRF). Since that time, most authorities have concluded that EDRF is NO (Ignarro et al. 1987; Palmer et al. 1987), however some researchers postulate that EDRF is actually an S-nitrosothiol that acts through NO transfer (Meyers et a1. 1990).


Nitric Oxide Erectile Dysfunction Vasoactive Intestinal Polypeptide Penile Erection Erectile Response 
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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Trinity J. Bivalacqua
  • Hunter C. Champion
  • Philip J. Kadowitz
  • Wayne J. G. Hellstrom

There are no affiliations available

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