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NO Effect on Penile Blood Flow and Lower Genitourinary Tract Function

  • Trinity J. Bivalacqua
  • Hunter C. Champion
  • Philip J. Kadowitz
  • Wayne J. G. Hellstrom
Part of the Nitric Oxide in Biology and Medicine book series (NOBM, volume 1)

Abstract

Nitric oxide (NO) is an unstable radical that exists primarily as a gas. For decades, NO was thought to be an environmental contaminant. Highly toxic, it was considered an unlikely candidate as a biological mediator. However, a landmark article by Furchgott and Zawadzki in 1980 described the release of a substance by the endothelial lining of blood vessels that was responsible for the vasorelaxation of smooth muscle in response to acetylcholine. They named this novel molecule endothelium-derived relaxing factor (EDRF). Since that time, most authorities have concluded that EDRF is NO (Ignarro et al. 1987; Palmer et al. 1987), however some researchers postulate that EDRF is actually an S-nitrosothiol that acts through NO transfer (Meyers et a1. 1990).

Keywords

Nitric Oxide Erectile Dysfunction Vasoactive Intestinal Polypeptide Penile Erection Erectile Response 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Trinity J. Bivalacqua
  • Hunter C. Champion
  • Philip J. Kadowitz
  • Wayne J. G. Hellstrom

There are no affiliations available

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