Effects of Acute, Oral Administration of Phenobarbital (1.6 mg/kg) to Healthy Subjects
The effects of barbiturates on the background EEG signal depend on the administered dose, with increments of fast frequency (peculiarly in the ∼15.0–25.0 Hz range) or low frequency EEG activities following administration at small to moderate or at large doses respectively. The increment of fast frequency EEG activity is referred to as distinctive of barbiturates [1–3] and has been documented in healthy volunteers 30–120 min after single, oral doses Phenobarbital (PB) as low as of 50 to 100 mg [4, 5], in spite of low drug plasma concentrations (below 6.9 µg/ml) and with pharmacokinetics and brain dynamics that were consistent with available evidence of early CNS bioavailability . The ∼15.0–25.0 Hz frequency interval appears to be a spectral parameter with peculiar sensitivity to PB, with substantial correlation between EEG effect and drug plasma concentration [4–5]. The power increase in this frequency segment occurs earlier and at lower doses on central electrodes, therefore allowing inference about possible generators
KeywordsPhenobarbital Barbiturate Thiopental Lewine
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