Effects of Acute, Oral Administration of Phenobarbital (1.6 mg/kg) to Healthy Subjects
The effects of barbiturates on the background EEG signal depend on the administered dose, with increments of fast frequency (peculiarly in the ∼15.0–25.0 Hz range) or low frequency EEG activities following administration at small to moderate or at large doses respectively. The increment of fast frequency EEG activity is referred to as distinctive of barbiturates [1–3] and has been documented in healthy volunteers 30–120 min after single, oral doses Phenobarbital (PB) as low as of 50 to 100 mg [4, 5], in spite of low drug plasma concentrations (below 6.9 µg/ml) and with pharmacokinetics and brain dynamics that were consistent with available evidence of early CNS bioavailability . The ∼15.0–25.0 Hz frequency interval appears to be a spectral parameter with peculiar sensitivity to PB, with substantial correlation between EEG effect and drug plasma concentration [4–5]. The power increase in this frequency segment occurs earlier and at lower doses on central electrodes, therefore allowing inference about possible generators
KeywordsRoot Mean Square GABAB Receptor Midline Thalamus Root Mean Square Signal Transmembrane Resistance
Unable to display preview. Download preview PDF.
- 5.Sannita, W.G., Balbi, A., Giacchino, F. and Rosadini, G. Quantitative EEG effects and plasma concentration of Phenobarbital, 50 mg and 100 mg single-dose oral administration to healthy volunteers: evidence of early CNS bioavailability. Neuropsychobiol. 1990, 205–212Google Scholar
- 6.Viswanathan, C.T., Booker, H.E. and Welling, P.G. Pharmacokinetics of Phenobarbital following single or repeated doses. J. clin. Pharmacol. 1979, 3: 382–389Google Scholar