Biomag 96 pp 980-990 | Cite as

MEG: Clinical Applications

  • J. P. Mäkelä
  • T. Elbert
  • R. Kakigi
  • J. Lewine
  • L. Lopez
  • T. Nagamine
  • N. Nakasato
  • M. Reite
  • W. Sannita

Abstract

During the last two decades, magnetoencephalography (MEG) has become available for monitoring human cortical activity. Although impressive results have been obtained with instruments having smaller coverage, new whole-scalp neuromagnetometers [1;2] began a new era in the neuromagnetic patient studies. The simultaneous activity of different widely spaced cortical areas can now be observed. This is an advantage in studying propagation of activity, e.g. in epilepsy, and also in studying functional alterations after lesions, which may occur far from the site of the lesion. Furthermore, individual variation is remarkable even in healthy subjects’ MEG responses to simple stimuli. For instance, some control subjects may show gross hemispheric differences in auditory evoked fields (AEFs) to simple tones [3;4]. Increased recording speed allows collection of large normative data bases, necessary for clinical applications.

Keywords

Permeability Depression Ischemia Dopamine Dementia 

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References

  1. [1]
    Ahonen, A, Hämäläinen, M, Kajola, M, et al. (1993) 122-channel SQUID instrument for investigating the magnetic signals from human brain. Physica Scripta, T40: 198–205.ADSCrossRefGoogle Scholar
  2. [2]
    Vrba, J, Betts, K, Burbank, M, et al. (1993) Whole cortex 64 channel SQUID biomagnetometer system. IEEE Transactions of Applied Superconductors, 3: 1878–1882.CrossRefGoogle Scholar
  3. [3]
    Mäkelä, JP, Ahonen, A, Hämäläinen, M, et al. (1993) Functional differences between auditory cortices of the two hemispheres revealed by whole-head neuromagnetic recordings. Human Brain Mapping, 1:48–56.CrossRefGoogle Scholar
  4. [4]
    Nakasato, N, Fujita, S, Seki, K, et al. (1995) Functional localization of bilateral auditory cortices using an MRI-linked whole head magnetoencephalography (MEG) system. Electroencephalography and clinical Neurophysiology, 94: 183–190.CrossRefGoogle Scholar
  5. [5]
    Wood, C C, Cohen, D, Cuffin, B N, et al. (1985) Electric sources in the human somatosensory cortex: identification by combined magnetic and potentials field recordings. Science, 227: 1051–1053.ADSCrossRefGoogle Scholar
  6. [6]
    Kawamura, T, Nakasato, N, Seki, K, et al. (1996) Neuromagnetic evidence of pre-and post-central cortical sources of somatosensory evoked responses. Electroencephalography and clinical Neurophysiology, 100: 44–50.CrossRefGoogle Scholar
  7. [7]
    Kawamura, T, Nakasato, N, Ohtomo, S, et al. Neuromagnetic identification of the somatosensory cortex in cases with arteriovenous malformation adjacent to the central sulcus. In this volume.Google Scholar
  8. [8]
    Hari, R, Aittoniemi, K, Järvinen, M L, et al. (1980) Auditory evoked transient and sustained magnetic fields of the human brain. Localization of neural generators. Experimental Brain Research, 40: 237–240.CrossRefGoogle Scholar
  9. [9]
    Pantev, C, Hoke, M and Lehnertz, K (1990) Identification of source of brain neuronal activity with high spatiotemporal resolution through combination of neuromagnetic source localization (NMSL) and magnetic resonance imaging (MRI). Electroencephalography and clinical Neurophysiology, 75: 173–184.CrossRefGoogle Scholar
  10. [10]
    Mäkelä, JP, Hari, R, Valanne, L, et al. (1991) Auditory evoked magnetic fields after cerebral vascular lesion. Annals of Neurology, 30: 76–82.CrossRefGoogle Scholar
  11. [11]
    Nakasato, N, Fujita, S and Matani, A Clinical application of the whole-head MEG: Auditory evoked response in patients with intracranial structural lesions. In: Baumgartner, C, Deecke, L, Stroink, G, Williamson, SJ (Eds.), Biomagnetism: Fundamental research and clinical applications. Studies in applied electromagnetics and mechanics. Elsevier/IOS press, Amsterdam, 1995: 186–190.Google Scholar
  12. [12]
    Kanno, A, Nakasato, N, Ohtomo, S, et al. Normalized NIOOm latency in the auditory evoked fields after surgical removal of temporal lobe gliomas. In this volume.Google Scholar
  13. [13]
    Seki, K, Nakasato, N, Fujita, S, et al. (1996) Neuromagnetic evidence that the P100m component of the pattern reversal visual evoked response originates in the bottom oc calcarine fissure. Electroencephalography and clinical Neurophysiology, in press.Google Scholar
  14. [14]
    Rossini, PM, Narici, L, Martino, G, et al. (1994) Analysis of interhemispheric asymmetries of somatosensory evoked magnetic fields to right and left median nerve stimulation. Electroencephalography and clinical Neurophysiology, 91: 476–482.CrossRefGoogle Scholar
  15. [15]
    Rossini, P.M, Pizzella, V, Rossi, S, et al. SEFs to median nerve and finger stimulation: analysis of interhemispheric asymmetries in healthy subjects and following hemispheric lesions. In this volume.Google Scholar
  16. [16]
    Beisteiner, R, Gomiscek, G, Erdler, M, et al. (1995) Comparing localization of conventional functional magnetic resonance imaging and magnetoencephalography. European Journal of Neuroscience, 7: 1121–1124.CrossRefGoogle Scholar
  17. [17]
    Maldjian, J, Atlas, S, Howard, R, et al. (1996) Functional magnetic resonance imaging of regional brain activity in patients with intracerebral artriovenous malformations before surgical or endovascular therapy. Journal of Neurosurgery, 84: 477–483.CrossRefGoogle Scholar
  18. [18]
    Mäkelä, JP, Salmelin, R, Kotila, M, et al. (1994) Neuromagnetic correlates of memory disturbances caused by infarction in anterior thalamus. Society for Neuroscience Abstracts, 20(1): 810.Google Scholar
  19. [19]
    Lewine, JD, Orrison, WW, Astur, RS, et al. Explorations of pathophysical spontaneous activity by macnetic source imaging. In: Baumgartner, C, Deecke, L, Stroink, G, Williamson, SJ (Eds.), Biomagnetism:Fundamental research and Clinical applications. Studies in applied electromagnetics and mechanics. Elsevier/IOS Press, Amsterdam, 1995: 55–59.Google Scholar
  20. [20]
    Lewine, JD, Orrison, WW, Sloan, JH, et al. Neuromagnetic assesment of pathophysiological brain activity induced by minor head trauma. In this volume.Google Scholar
  21. [21]
    Vieth, J, Kober, H and Grummich, P (1996) Sources of spontaneous slow waves associated with brain lesions, localised by using the MEG. Brain Topography, 8: 215–221.CrossRefGoogle Scholar
  22. [22]
    Vieth, JB, Kober, H, Stippich, C, et al. Time course of abnormal MEG activity associated with transient ischemic attacks. In this volume.Google Scholar
  23. [23]
    Kakigi, R, Koyama, S, Hoshiyama, M, et al. (1995) Pain-related magnetic fields following painful CO2 laser stimulation in man. Neuroscience Letters, 192: 45–48.CrossRefGoogle Scholar
  24. [24]
    Hari, R, Kaukoranta, E, Reinikainen, K, et al. (1983) Neuromagnetic localization of cortical activity evoked by painful dental stimulation in man. Neuroscience Letters, 42: 77–82.CrossRefGoogle Scholar
  25. [25]
    Huttunen, J, Kobal, G, Kaukoranta, E, et al. (1986) Cortical responses to painful CO2 stimulation of the nasal mucosa. Electroencephalography and clinical Neurophysiology, 64: 347–349.CrossRefGoogle Scholar
  26. [26]
    Kitamura, Y, Kakigi, R, Hoshiyama, M, et al. (1995) Pain-related somatosensory evoked magnetic fields. Electroencephalography and clinical Neurophysiology, 95: 463–474.CrossRefGoogle Scholar
  27. [27]
    Jenkins, WM, Merzenich, MM and Recanzone, G (1990) Neocortical representational dynamics in adult primates: implications for neuropsychology. Neuropsychologia, 28: 573–584.CrossRefGoogle Scholar
  28. [28]
    Wang, X, Merzenich, MM, Sameshima, K, et al. (1995) Remodeling of hand representation in adult cortex determined by timing of tactile stimulation. Nature, 378: 71–75.ADSCrossRefGoogle Scholar
  29. [29]
    Elbert, T, Flor, H, Birbaumer, N, et al. (1994) Evidence for extensive reorganization of the somatosensory cortex in adult humans after nervous system injury. NeuroReport, 5: 2593–2597.CrossRefGoogle Scholar
  30. [30]
    Yang, TT, Gallen, C, Ramachandran, VS, et al. (1994) Noninvasive detection of cerebral plasticity in adult human somatosensory cortex. NeuroReport, 5: 701–704.CrossRefGoogle Scholar
  31. [31]
    Flor, H, Elbert, T, Knecht, S, et al. (1995) Phantom-limb pain as a perceptual correlate of cortical reorganization following arm amputation. Nature, 375: 482–484.ADSCrossRefGoogle Scholar
  32. [32]
    Knecht, S, Henningsen, H, Elbert, T, et al. (1995) Cortical reorganization in human amputees and mislocalization of painful stimuli to the phantom limb. Neuroscience Letters, 201: 262–264.CrossRefGoogle Scholar
  33. [33]
    Knecht, S, Henningsen, H, Elbert, T, et al. (1996) Reorganizational and perceptual changes after amputation. Brain, In press.Google Scholar
  34. [34]
    Flor, H, Braun, Ch, Birbaumer, N, et al. Chronic pain enhances the magnitude of the magnetic field evoked at the site of pain. In: Baumgartner, C, Deecke, G, Stroink, G, Williamson, SJ (Eds.), Biomagnetism: Fundamental research and Clinical applications. Studies in applied electromagnetics and mechanics. Elsevier/IOS Press, Amsterdam, 1995: 107–111.Google Scholar
  35. [35]
    Elbert, T, Pantev, C, Wienbruch, C, et al. (1995) Increased cortical representation of the fingers of the left hand in string players. Science, 270: 305–307.ADSCrossRefGoogle Scholar
  36. [36]
    Rockstroh, B, Vanni, S, Elbert, T, et al. Extensive somatosensory stimulation alters somatosensory evoked fields. In this volume.Google Scholar
  37. [37]
    Mogilner, A, Grossman, A, Ribary, U, et al. (1993) Somatosensory cortical plasticity in adult humans revealed by magnetoencephalography. Proceedings of the National Academy of Sciences of USA, 90: 3593–3597.ADSCrossRefGoogle Scholar
  38. [38]
    Elbert, T, Sterr, A, Rockstroh, B, et al. Cortical reorganization in amputees: alterations of somatosensory representation in the hemisphere contralateral to the intact side. In this volume.Google Scholar
  39. [39]
    Florence, SL, Wall, JT and Kaas, JH (1991) Cortical projections from the skin of the hand in squirrel monkeys. Journal of Comparative Neurology, 311: 563–578.CrossRefGoogle Scholar
  40. [40]
    Pantev, C, Bertrand, O, Eulitz, C, et al. (1995) Mirror-image tonotopy of different areas of human auditory cortex revealed by simultaneous magnetic and electric recordings. Electroencephalography and clinical Neurophysiology, 94: 26–60.CrossRefGoogle Scholar
  41. [41]
    Mühlnickel, W, Flor, H, Elbert, T, et al. Deviations from the tonotopic map are correlated with tinnitus strength. In this volume.Google Scholar
  42. [42]
    Mäkelä, JP and Hari, R Long-latency auditory evoked magnetic fields. In: Sato, S. (Eds.), Magnetoencephalography: Clinical Applications and Comparison of EEG. Raven Press, 1990: 177–191.Google Scholar
  43. [43]
    Phillips, DP, Semple, MN, Calford, MB, et al. (1994) Level-dependent representation of stimulus frequency in the cat primary auditory cortex. Experimental Brain Research, 102: 210–226.CrossRefGoogle Scholar
  44. [44]
    Vasama, J-P, Mäkelä, JP, Pyykkö, I, et al. (1995) Abrupt unilateral deafness modifies function of human auditory pathways. NeuroReport, 6: 961–964.CrossRefGoogle Scholar
  45. [45]
    Vasama, J-P and Mäkelä, JP (1995) Auditory pathway plasticity in adult humans after idiopathic sudden unilateral sensorineural hearing loss. Hearing Research, 87: 132–140.CrossRefGoogle Scholar
  46. [46]
    Irvine, DRF and Rajan, RR (1993) Plasticity in the frequency organization of auditory cortex of adult mammals with restricted cortical lesions. Biomedical Research, 14: 55–59.Google Scholar
  47. [47]
    Ahissar, E and Ahissar, M (1994) Plasticity in auditory cortical circuitry. Current Opinion in Neurobiology, 4: 580–587.CrossRefGoogle Scholar
  48. [48]
    Mäkelä, JP, Hari, R, Karhu, J, et al. (1993) Suppression of magnetic mu rhythm during parkinsonian tremor. Brain Research, 617: 189–193.CrossRefGoogle Scholar
  49. [49]
    Volkmann, J, Joliot, M, Mogilner, A, et al. (1996) Central motor loop oscillations in parkinsonian resting tremor revealed by magnetoencephalography. Neurology, 46: 1359–1370.CrossRefGoogle Scholar
  50. [50]
    Sannita, WG, Lewine, JD, Maclin, EL, et al. Quantitative EEG and MEG effects in healthy subjects of acute oral phenobarbital (100 mg). In this volume.Google Scholar
  51. [51]
    Wiebruch, C, Eulitz, C, Lehnertz, K, et al. Methohexital-induced changes in spectral power of neuromagnetic signals: reduced enhancement of beta-band power over the hemisphere ipsilateral to the epileptogenic focus. In this volume.Google Scholar
  52. [52]
    Kraut, MA, Arezzo, JC and Vaughan, H (1990) Inhibitory processes in the flash evoked potential of the monkey. Electroencephalography and clinical Neurophysiology, 76: 440–452.CrossRefGoogle Scholar
  53. [53]
    Arakawa, K, Peachey, NS, Celesia, GG, et al. (1993) Component-specific effects of physostigmine on the cat visual evoked potential. Experimental Brain Research, 95: 271–276.CrossRefGoogle Scholar
  54. [54]
    Mavroudakis, N, Brunko, E, Nogueira, MC, et al. (1991) Acute effects of diphenylhydantoin on peripheral and central somatosensory conduction. Electroencephalography and clinical Neurophysiology, 78: 263–266.CrossRefGoogle Scholar
  55. [55]
    Bodis-Wollner, I (1990) Visual deficits related to dopamine deficiency in experimental animals and Parkinson’s disease patients. Trends in Neurosciences, 13: 296–302.CrossRefGoogle Scholar
  56. [56]
    Sannita, WG, Balestra, V, Di Bon, G, et al. (1993) Human Flash-VEP and quantitative EEG are independently affected by acute scopolamine. Electroencephalography and clinical Neurophysiology, 86: 275–282.CrossRefGoogle Scholar
  57. [57]
    Singer, W (1993) Synchronization of cortical activity and its putative role in information processing and learning. Annual Review of Physiology, 55: 349–374.CrossRefGoogle Scholar
  58. [58]
    Sannita, WG, Lopez, L, Piras, C, et al. (1995) Scalp-recorded oscillatory potentials evoked by transient pattern-reversal stimulation in man. Electroencephalography and clinical Neurophysiology, 96: 206–218.CrossRefGoogle Scholar
  59. [59]
    Lopez, L, Narici, L, Conforto, S, et al. Oscillatory retinal and cortical responses to luminance stimulation: eccentricity function and effect of acute scopolamine. In this volume.Google Scholar
  60. [60]
    Shiomi, Y, Fujiki, N, Hirano, S, et al. (1996) Tinnitus remission by lidocaine demonstrated by auditory evoked magnetoencephalogram: preliminary report. Association for Resarch in Otolaryngology, book of abstracts, 19: 13.Google Scholar
  61. [61]
    Jäntti, V, Baer, G, Yli-Hankala, A, et al. (1995) MEG burst suppression in an anaesthetized dog. Acta Anesthesiologica Scandinavica, 39: 126–128.CrossRefGoogle Scholar
  62. [62]
    Lopez, L, Chan, CY, Okada, YC, et al. (1991) Multimodal characterization of population responses evoked by applied electric field in vitro: extracellular potential, magnetic evoked field, transmembrane potential and current source density analysis. Journal of Neuroscience, 11: 1998–2010.Google Scholar
  63. [63]
    Reite, M, Teale, P, Goldstein, L, et al. (1989) Late auditory evoked magnetic sources may differ in the left hemisphere of schizophrenic patients. Archives of General Psychiatry, 46: 565–572.CrossRefGoogle Scholar
  64. [64]
    Tiihonen, J, Hari, R, Naukkarinen, H, et al. (1992) Modified activity of the human auditory cortex during auditory hallucinations. American Journal of Psychiatry, 149: 255–257.Google Scholar
  65. [65]
    David, AS, Woodruff, PWR, Howard, R, et al. (1996) Auditory hallucinations inhibit exogeneous activation of auditory association cortex. NeuroReport, 7: 932–936.CrossRefGoogle Scholar
  66. [66]
    Reite, M, Sheeder, J, Teale, P, et al. (1996) Magnetic source imaging evidence of sex differences in cerebral lateralization in schizophrenia. Archives of General Psychiatry, in press.Google Scholar
  67. [67]
    Reite, M, Teale, P, Sheeder, J, et al. (1996) Neuropsychiatric applications of MEG. Electroencephalography and clinical Neurophysiology, Suppl. Visualization of Information processing in the human brain; Recent advances in MEG and Functional MRI: in press.Google Scholar
  68. [68]
    Kaufman, L, Curtis, S, Wang, J-Z, et al. (1991) Changes in cortical activity when subjects scan memory for tones. Electroencephalography and clinical Neurophysiology, 82: 266–284.CrossRefGoogle Scholar
  69. [69]
    Reite, M, Teale, P, Sheeder, J, et al. (1996) MEG evidence of abnormal early auditory function in schizophrenia. Biological Psychiatry, in press.Google Scholar
  70. [70]
    Salmelin, R, Mäkelä, JP, Heikman, P, et al. (1996) Human brain rhythms and electroconvulsive therapy. Society for Neuroscience Abstracts.Google Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • J. P. Mäkelä
    • 1
    • 2
  • T. Elbert
    • 3
  • R. Kakigi
    • 4
  • J. Lewine
    • 5
  • L. Lopez
    • 6
  • T. Nagamine
    • 7
  • N. Nakasato
    • 8
  • M. Reite
    • 9
  • W. Sannita
    • 10
    • 11
  1. 1.Low Temperature LaboratoryHelsinki University of TechnologyEspooFinland
  2. 2.Central Military HospitalHelsinkiFinland
  3. 3.University of KonstanzKonstanzGermany
  4. 4.Department of Integrative PhysiologyNational Institute for Physiological SciencesOkazakiJapan
  5. 5.The New Mexico Institute of NeuroimagingAlbuquerqueUSA
  6. 6.Institute for Advanced Biomedical TechnologiesChietiItaly
  7. 7.Department of Brain PathophysiologyKyoto University School of MedicineKyotoJapan
  8. 8.Department of NeurosurgeryTohoku UniversitySendaiJapan
  9. 9.Health Sciences CenterUniversity of ColoradoDenverUSA
  10. 10.Center of Neuropsychoactive DrugsUniversity of GenovaGenovaItaly
  11. 11.State University of New YorkNew YorkUSA

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