Biomag 96 pp 971-974 | Cite as

Cognitive Temporal Binding and its Relation to 40Hz Activity in Humans: Alteration During Dyslexia

Conference paper


Spontaneous oscillatory electrical activity in the human brain at a frequency near 40-Hz and its reset within thalamo-cortical systems by sensory stimulation has been proposed earlier [1–3] and has been suggested to be related to cognitive processing and to the temporal binding of sensory stimuli [3,4]. In particular, we demonstrated spontaneous 40-Hz coherent magnetic activity in the awake and in REM sleep states that is reduced during delta sleep [3]. This 40-Hz magnetic oscillation has been shown to be reset by sensory stimuli only in the awake state but not during REM or delta sleep. Because spontaneous 40-Hz oscillation was seen in wakefulness and in dreaming, we proposed it as a correlate of cognition, probably resultant from coherent 40-Hz resonance between thalamocortical specific and nonspecific loops [3].


Auditory Stimulus Interstimulus Interval Perceptual Separation Neurophysiological Correlate Dyslexic Subject 
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  1. [1]
    Llinás, R. Intrinsic electrical properties of mammalian neurons and CNS function, In: Fidia Research Foundation Neuroscience Award Lectures, Raven Press, New York, 1990, 4: 175–194.Google Scholar
  2. [2]
    Ribary, U., Ioannides, A.A., Singh, K.D., Hasson, R., Bolton, J.P.R., Lado, F., Mogilner, A., and Llinás, R. Magnetic field tomography (MFT) of coherent thalamo-cortical 40-Hz oscillation in humans, Proc. Natl. Acad. Sci. USA, 1991, 88: 11037–11041.ADSCrossRefGoogle Scholar
  3. [3]
    Llinás, R., and Ribary, U. Coherent 40-Hz oscillation characterizes dream state in humans, Proc. Natl. Acad. Sci. USA, 1993, 90: 2078–2081.ADSCrossRefGoogle Scholar
  4. [4]
    Joliot, M., Ribary, U., and Llinás, R. Neuromagnetic coherent oscillatory activity in the vicinity of 40-Hz coexists with cognitive temporal binding in the human brain, Proc. Natl. Acad. Sci. USA, 1994, 91: 11748–11751.ADSCrossRefGoogle Scholar
  5. [5]
    Llinás, R. Is dyslexia a dyschronia? Annal NY Acad. Sci., 1993, 682: 48–56.ADSCrossRefGoogle Scholar
  6. [6]
    Tallal, P., Miller, S. and Fitch, R.H. Neurobiological basis of speech: A case for the preeminence of temporal processing, Annal NY Acad. Sci., 1993, 682: 27–47.ADSCrossRefGoogle Scholar
  7. [7]
    Miller, G.A., and Taylor, W.G. The perception of repeated bursts of noise, J. Acoust. Soc. Am., 1948, 20: 171–182.ADSCrossRefGoogle Scholar
  8. [8]
    Hirsh, I.J. Auditory perception of temporal order, J. Acoust. Soc. Am., 1959, 31: 759–767.ADSCrossRefGoogle Scholar
  9. [9]
    Tallal, P. Auditory temporal perception, phonics, and reading disabilities in children, Brain and Language, 1980,9: 182–198.CrossRefGoogle Scholar
  10. [10]
    Tallal, P., Miller, S.L., Bedi, G., Byma, G., Wang, X., Nagarajan, S.S., Schreiner, C., Jenkins, W.M., and Merzenich, M.M. Language comprehension in language-learning impaired children improved with acoustically modified speech, Science, 1996, 271: 81–84.ADSCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  1. 1.Center for Neuromagnetism, Dept. of Physiology and NeuroscienceNew York University Medical CenterNew YorkUSA
  2. 2.SHFJ, DRIPP-CEAOrsayFrance
  3. 3.Center for Molecular and Behavioral NeuroscienceRutgers UniversityNewarkUSA

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