A Model of Phagosome Motion within Cells Incorporating Viscoelasticity Based on Cytomagnetometric Measurements
Cytomagnetometry was proposed more than ten years ago  but has not yet acquired the citizenship in biophysics. The main reason seems to be that the method is macroscopic and crude while there are advanced microscopic biophysical techniques available to handle the molecules themselves in the cells. Indeed, these new techniques have made it possible to measure even the force produced by one actin molecule. However, there are still quite limited possibilities for measuring the activities within the cells in vivo. We believe that cytomagnetometry using magnetic particles provides such possibilities; the movement of the intracellular structures can be detected non-invasively by measuring the magnetic field from the cells, and furthermore, magnetic particles within the cells can be manipulated by an external magnetic field easily.
KeywordsStochastic Differential Equation Magnetic Particle Elastic Body Relaxation Curve Pulse Magnetization
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- Wiegand, J., Moeller, W., Nemoto, I. and Stahlhofen, W., Magnetic microparticles can measure intracellular viscoelasticity in vivo, IN:Baumgartner, C., Deecke, L., Stroink, G. and Williamson, S.J. Biomagnetism, Amsterdam, Elsevier, 1995.Google Scholar