Skip to main content
SpringerLink
Log in

Male Fertility in Congenital Adrenal Hyperplasia

An Invited Contribution

  • Conference paper
Therapeutic Outcome of Endocrine Disorders

Part of the book series: Serono Symposia USA ((SERONOSYMP))

  • 97 Accesses

Abstract

It has been shown that the majority of noncentral precocious sexual developments in boys are due to overproduction of adrenal androgens in patients with late onset congenital adrenal hyperplasia (CAH) with 21-hydroxylase deficiency. In these cases the diagnosis is easily suspected because the testes size remains prepubertal. This characteristic has diagnostic value, especially in patients with bone ages of 13 or more years (1). This can be physiologically explained by the inhibitory effect that high levels of circulating adrenal androgens exert on the secretion of gonadotropins.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 79.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 99.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Wilkins L. The diagnosis and treatment of endocrine disorders in childhood and adolescence. Springfield, Ill Thomas, 1965;401–5.

    Google Scholar 

  2. Wilkins L, Cara J. Further studies on the treatment of congenital adrenal hyperplasia with cortisone. V. effects of cortisone-therapy on testicular development. J Clin Endocrinol Metab 1954; 14: 287–96.

    Article  PubMed  CAS  Google Scholar 

  3. Penny R, Olambiwonnu NO, Frasier SD. Precocious puberty following treatment in a six year old male with congenital adrenal hyperplasia: studies of serum luteinizing hormone (LH) and follicle stimulating hormone (FSH) and plasma testosterone. J Clin Endocrinol Metab 1973; 36: 920–24.

    Article  PubMed  CAS  Google Scholar 

  4. Molitor JT, Chertow BS, Fariss BL. Long-term follow up of a patient with congenital adrenal hyperplasia and failure of testicular development. Fertil Steril 1973; 24: 319–23.

    PubMed  CAS  Google Scholar 

  5. Urban MD, Lee PA, Migeon CJ. Adult height and fertility in men with congenital adrenal hyperplasia. N Engl J Med 1978; 199: 1392–96.

    Article  Google Scholar 

  6. Glenthoj A, Damkjaer M, Neilsen M, Stamp J. Congenital adrenal hyperplasia due to 11βhydroxylase deficiency: final diagnosis in adult age in three patients. Acta Endocrinol 1980; 93: 94–99.

    PubMed  CAS  Google Scholar 

  7. Wischusen J, Baker HWG, Hudson B. Reversible male infertility due to congenital adrenal hyperplasia. Clin Endocrinol (Oxf) 1981; 14: 571–77.

    Article  CAS  Google Scholar 

  8. Mirsky HA, Hines JH. Infertility in a man with 21-hydroxylase deficient congenital adrenal hyperplasia. J Urol 1989; 142(1): 111–13.

    PubMed  CAS  Google Scholar 

  9. Augarten A, Weissenserg R, Pariente C, Sack J. Reversible male infertility in late onset congenital adrenal hyperplasia. J Endocrinol Invest 1991; 14: 237–40.

    PubMed  CAS  Google Scholar 

  10. Iwamoto T, Yajima M, Tanaka H, Minagawa N, Osada R. A case report: reversible male infertility due to congenital adrenal hyperplasia. Nippon-Hinyokika-Gakkai-Zasshi 1993; 84: 2031–34.

    PubMed  CAS  Google Scholar 

  11. Bonacorsi AC, Adler I, Figueiredo JC. Male infertility due to congenital adrenal hyperplasia: testicular biopsy findings, hormonal evaluation and therapeutic results in three patients. Fertil Steril 1987; 47: 664–70.

    Google Scholar 

  12. Prader A, Zachmann M, Illig R. Normal spermatogenesis in adult males with congenital adrenal hyperplasia after discontinuation of therapy. In: Congenital adrenal hyperplasia. Lee PA, Plotnick LP, Kowarski, et al., eds. Baltimore: Baltimore University Park Press, 1977: 397–401.

    Google Scholar 

  13. Willi V, Atares M, Prader A, Zachmann M. Testicular adrenal-like tissue (TALT) in congenital adrenal hyperplasia detection by ultrasonography. Pediatr Radiol 1991; 21(4): 284–87.

    Article  PubMed  CAS  Google Scholar 

  14. Rivarola MA, Saez JM, Migeon CJ. Studies of androgens in patients with congenital adrenal hyperplasia. J Clin Endocrinol Metab 1967; 27: 624–30.

    Article  PubMed  CAS  Google Scholar 

  15. Chowdhury AK, Steinberger E. Effect of 5 alpha reduced androgens on sex accesory organs, initiation and maintenance of spermatogenesis in the rat. Biol Reprod 1975; 12: 609–17.

    Article  PubMed  CAS  Google Scholar 

  16. Chemes HE, Podestá E, Rivarola MA. Action of testosterone, dihydrotestosterone in 5 alpha androstane, 3 alpha, 17 beta diol on the spermatogenesis of immature rats. Biol Reprod 1976; 14: 322–38.

    Article  Google Scholar 

  17. Chemes HE, Dym M, Raj HGM. The role of gonadotropins and testosterone on initiation of spermatogenesis in the immature rats. Biol Reprod 1979; 21: 241–69.

    Article  PubMed  CAS  Google Scholar 

  18. Almiron I, Domené H, Chemes HE. The hormonal regulation of premeiotic steps of spermatogenesis in the newborn rat. J Androl 1984; 5: 235–42.

    PubMed  CAS  Google Scholar 

  19. Ahmad N, Haltmeyer GC, Eiknes KB. Maintenance of spermatogenesis in rats with intratesticular implants containing testosterone or dihydrotestosterone. Biol Reprod 1973; 8: 111–19.

    Google Scholar 

  20. Chemes HE. Cambios testiculares asociados al comienzo y desarrollo de la pubertad humana. In: Fisiopatologia de la Pubertad. Bergadá C, Rivarola M, eds. Buenos Aires: Ergon, 1986;49–67.

    Google Scholar 

  21. Clermont Y, Harvery SC. Duration of the cycle of the seminiferous epithelium of normal hypophysectomized and hypophysectomized hormone treated albino rats. Endocrinology 1965; 76: 80–89.

    Article  PubMed  CAS  Google Scholar 

  22. Boccabella AV. Reinitiation and retardation of spermatogenesis with testosterone propionate and other hormones after long term post hypophysectomy regression period. Endocrinology 1963; 72: 787–98.

    Article  CAS  Google Scholar 

  23. Steinberger E, Duckett GE. Hormonal control of spermatogenesis. J Reprod Fert 1967;(suppl 2): 75–87.

    Google Scholar 

  24. Dym M, Raj HGM, Lin YC, Chemes HE, Kotite NJ, Hayfeh SM, et al. Is FSH required for maintenance of spermatogenesis in adult rat? J Reprod Fert 1979;(suppl 26): 175–81.

    CAS  Google Scholar 

  25. Tapanaimen JS, Aittomãki K, Vaskivmo T, Huhtaniemi I. Men homozygous for an inactivating mutation of the follicle-stimulationg hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Nature Genet 1997; 15: 205–6.

    Article  Google Scholar 

  26. Rajendra Kumar T, Wang Y, Lu N, Matzuk MM. Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nature Genet 1997; 15: 201–4.

    Article  Google Scholar 

  27. Radfar N, Bartter FC, Easley R, et al. Evidence for androgens LH suppression in a man with bilateral testicular tumors and congenital adrenal hyperplasia. J Clin Endocrin Metab 1977; 45: 1194–204.

    Article  CAS  Google Scholar 

  28. Cutfield RG, Bateman JM, Odell WE. Infertility caused by bilateral testicular masses secondary to congenital adrenal hyperplasia. Fertil Steril 1983; 40: 809–14.

    PubMed  CAS  Google Scholar 

Download references

Authors
  1. César Bergadá
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ana Claudia Keselman
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Stella Maris Campo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. María Gabriela Ropelato
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Héctor Edgardo Chemes
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Department of Psychiatry School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, NC, 27599, USA

    Brian Stabler Ph.D.

  2. Department of Pediatrics College of Medicine, University of South Florida, All Children’s Hospital, St. Petersburg, FL, 33701, USA

    Barry B. Bercu M.D.

Rights and permissions

Reprints and permissions

Copyright information

© 2000 Springer Science+Business Media New York

About this paper

Cite this paper

Bergadá, C., Keselman, A.C., Campo, S.M., Ropelato, M.G., Chemes, H.E. (2000). Male Fertility in Congenital Adrenal Hyperplasia. In: Stabler, B., Bercu, B.B. (eds) Therapeutic Outcome of Endocrine Disorders. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-1230-0_21

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-1230-0_21

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-7052-2

  • Online ISBN: 978-1-4612-1230-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation