The Non-Growth Hormone-Deficient Child: Does Therapy with Growth Hormone Produce Benefit?
The availability of abundant supplies of recombinant human growth (GH) has made it possible to test the effects of GH treatment on short children with diagnoses other than GH deficiency. For example, treatment of girls with Turner Syndrome and children with chronic renal failure has been observed to accelerate rates of statural growth and to increase adult height (1,2). Despite improvement over the last 30-35 years in the tools used for determining the causes of short stature, no specific diagnosis is made in a large proportion of the short children who are brought to medical attention. These children are referred to as having “normal” short stature, idiopathic short stature, or are given one of a variety of other designations (Table 10.1). The number and nature of the mechanisms involved in the slow growth and short stature of these patients is not known.
KeywordsGrowth Hormone Short Stature Standard Deviation Score Turner Syndrome Adult Height
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