The Non-Growth Hormone-Deficient Child: Does Therapy with Growth Hormone Produce Benefit?

  • Louis E. Underwood
  • Brian Stabler
Conference paper
Part of the Serono Symposia USA book series (SERONOSYMP)


The availability of abundant supplies of recombinant human growth (GH) has made it possible to test the effects of GH treatment on short children with diagnoses other than GH deficiency. For example, treatment of girls with Turner Syndrome and children with chronic renal failure has been observed to accelerate rates of statural growth and to increase adult height (1,2). Despite improvement over the last 30-35 years in the tools used for determining the causes of short stature, no specific diagnosis is made in a large proportion of the short children who are brought to medical attention. These children are referred to as having “normal” short stature, idiopathic short stature, or are given one of a variety of other designations (Table 10.1). The number and nature of the mechanisms involved in the slow growth and short stature of these patients is not known.


Growth Hormone Short Stature Standard Deviation Score Turner Syndrome Adult Height 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Rosenfeld RG, Frane J, Attie KM, Brazel JA, Burstein S, Cara JF, et al Six year results of a randomized, prospective trial of human growth hormone and oxandrolone in Turner syndrome. J Pediatr 1992; 121: 49–55.PubMedCrossRefGoogle Scholar
  2. 2.
    Fine RN, Kohut E, Brown D, Kuntze J, Attie KM. Long-term treatment of growth retarded children with chronic renal insufficiency, with recombinant human growth hormone. Kidney Internat 1996; 49: 781–85.CrossRefGoogle Scholar
  3. 3.
    Hopwood NJ, Hintz RL, Gertner JM, Attie KM, Johanson AJ, Baptista J, et al Growth response of children with non-growth hormone deficiency and marked short stature during 3 years of growth hormone therapy. J Pediatr 1993; 123: 215–22.PubMedCrossRefGoogle Scholar
  4. 4.
    Hindmarsh PC, Brook CGD. Effect of growth hormone on short normal children. Br Med J 1987; 295: 573–77.CrossRefGoogle Scholar
  5. 5.
    Wit JM, Fokker MG, deMuinck Keizer-Schrama SMPH, et al Effects of two years of methionyl growth hormone therapy in low-dosage regimens to prepubertal children with short stature, subnormal growth rate and normal growth hormone response to secretagogues. J Pediatr 1989; 115: 720–25.PubMedCrossRefGoogle Scholar
  6. 6.
    Bierich JR, Nolte K, Drews K, Brugmann G. Constitutional delay of growth and adolescence. Results of short-term and long-term treatment with growth hormone. Acta Endocrinol 1992; 127: 392–96.PubMedGoogle Scholar
  7. 7.
    Albertsson-Wikland K. Characteristics of children with idiopathic short stature in the Kabi Pharmacia International Growth Study, and their response to growth hormone treatment. Acta Paediatr 1993; 391(suppl): 75–78.CrossRefGoogle Scholar
  8. 8.
    Laron Z, Klinger B, Anin S, Pertzelan A, Lilos P. Growth during and 2 years after stopping GH treatment in prepubertal children with idiopathic short stature. J Ped Endocrinol Metab 1997; 10: 191–96.Google Scholar
  9. 9.
    Schmitt K, Blumel P, Waldhor T, Lassi M, Tulzer G, Frisch H. Short-and long-term (final height) data in children with normal variant short stature treated with growth hormone. Eur J Pediatr 1997; 156: 680–83.PubMedCrossRefGoogle Scholar
  10. 10.
    Kawai M, Momio T, Yorfuji T, Yamanaka C, Sasaki H, Furusho K. Unfavorable effects of growth hormone therapy on the final height of boys with short stature not caused by growth hormone deficiency. J Pediatr 1997; 130: 205–9.PubMedCrossRefGoogle Scholar
  11. 11.
    Loche S, Cambiaso P, Setzu S, Carta D, Marini R, Borrelli P, et al Final height after growth hormone therapy in non-growth hormone deficient children with short stature. J Pediatr 1994; 125: 196–200.PubMedCrossRefGoogle Scholar
  12. 12.
    Wit JM, Boersma B, deMuinch Keizer-Schrama SMPF, Nienhuis HE, Oostdijk W, et al Long-term results of growth hormone therapy in children with short stature, subnormal growth rate and normal growth hormone response to secretagogues. Clin Endocrinol 1995; 42: 365–72.CrossRefGoogle Scholar
  13. 13.
    Hindmarsh P, Brook CGD. Final height of short normal children treated with growth hormone. Lancet 1996; 348: 13–16.PubMedCrossRefGoogle Scholar
  14. 14.
    Guyda HJ. Growth hormone treatment of non-growth hormone deficient subjects: the international task force report. Clin Pediatr Endocrinol 1996; 5(suppl 7): 11–18.CrossRefGoogle Scholar
  15. 15.
    Hintz RL, for U.S. Collaborative NCGS. Presented to the combined meeting of the European Society for Pediatric Endocrinology and the Lawson Wilkins Pediatric Endocrine Society. Stockholm, Sweden, June 1997.Google Scholar
  16. 16.
    Cuttler L, Silvers JB, Singh J, Marrero U, Finklestein B, Tannin G, et al Short stature and growth hormone therapy: a national study of physician recommendation patterns. JAMA 1996; 276: 531–37.PubMedCrossRefGoogle Scholar
  17. 17.
    Voss LD, Mulligan J. The short normal child in school: Self-esteem, behavior, and attainment before puberty (The Wessex Growth Study). In: Stabler B, Underwood LE, eds. Growth, stature, and adaptation. Chapel Hill, NC: University of North Carolina, 1994.Google Scholar
  18. 18.
    Sandberg DE, Brook AE, Campos SP. Short stature in middle childhood: a survey of psychological functioning in a clinically referred sample. In: Stabler B, Underwood LE, eds. Growth, stature, and adaptation. Chapel Hill, NC: University of North Carolina, 1994.Google Scholar
  19. 19.
    Vance MD, Ingersoll GM, Golden MP. Short stature in a nonclinical sample: not a big problem. In Stabler B, Underwood LE eds. Growth, stature, and adaptation. Chapel Hill, NC: University of North Carolina 1994.Google Scholar
  20. 20.
    Skuse D, Gilmore J. Quality of life of children with normal short stature. Clin Pediatr Endocrinol 1997; 6(suppl 9): 29–37.CrossRefGoogle Scholar
  21. 21.
    Downey AB, Mulligan J, McCaughey ES, Stratford RJ, Betts PR, Voss LD. Psychological response to growth hormone treatment in short normal children. Arch Dis Child 1996; 75: 32–35.CrossRefGoogle Scholar
  22. 22.
    Lieberman E, Pilpel D, Carel CA, Levi E, Zadik Z. Coping and satisfaction with growth hormone treatment among short-stature children. Horm Res 1993; 40: 128–33.CrossRefGoogle Scholar
  23. 23.
    Stabler B, Clopper RR, Siegel PT, Stoppani C, Compton PG, Underwood LE. Academic achievement and psychological adjustment in short children. J Dev Behav Pediatr 1994; 14: 1–6.CrossRefGoogle Scholar
  24. 24.
    Stabler B, Siegel PT, Clopper RR, Stoppani CE, Compton PG, Underwood LE. Behavior change after growth hormone treatment of children with short stature. J Pediatr 1998; 133: 366–73.PubMedCrossRefGoogle Scholar
  25. 25.
    Eminson DM, Powell RP, Hollis S. Cognitive behavioral intervention with short statured boys: apilot study. In: Stabler B, Underwood LE eds.. Growth, stature, and adaptation. Chapel Hill, NC: University of North Carolina, 1994.Google Scholar

Copyright information

© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Louis E. Underwood
  • Brian Stabler

There are no affiliations available

Personalised recommendations