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Integrative Biology and Genetic Variability: MODS’ Next Frontiers

  • Timothy G. Buchman

Abstract

Care of the critically ill patient has been revolutionized through advances in prehospital care, operative care, intensive care, and rehabilitative care. Systematic observation and dozens of rigorous clinical trials have yielded a complex picture of the patient in physiologic crisis who is at greatest risk for the multiple organ dysfunction syndrome (MODS). Widespread inflammation was suggested to be prerequisite to MODS, and a general hypothesis was articulated: that interruption of the biochemical cascade leading to this widespread inflammation would attenuate the progression and severity of MODS. More than two dozen clinical trials later, this simplistic hypothesis has been disproven. The purpose of this chapter is to explore the reasons why this apparently logical hypothesis concerning the pathogenesis of MODS might be incorrect and to consider alternative formulations of MODS pathogenesis.

Keywords

Heart Rate Variability Multiple Organ Dysfunction Syndrome Infinite Impulse Response Infinite Impulse Response Filter15 Integrative Biology 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Timothy G. Buchman

There are no affiliations available

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