Peritoneal Tissue Repair Cells

  • Kathleen E. Rodgers


The function of two types of cells (peritoneal leukocytes and tissue repair cells [TRC] or mesothelial cells) in the repair of peritoneal injury has been extensively studied. The contribution of these cells to the process of peritoneal repair and studies on the functional alterations of these cells following surgical trauma and exposure to various growth factors are reviewed as part of this chapter.


Mesothelial Cell Adhesion Formation Fibrinolytic Activity Human Peritoneal Mesothelial Cell Peritoneal Leukocyte 
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  1. 1.
    van Furth R, Cohn ZA. The origin and kinetics of mono-nuclear phagocytes. J Exp Med 1968; 128:415–435.PubMedCrossRefGoogle Scholar
  2. 2.
    Orita H, Nakamura RM, diZerega GS. Kinetic analysis of postoperative peritoneal healing: incorporation of proline and glucosamine by exudative and tissue repair cells. Surg Forum 1985; 36:467–468.Google Scholar
  3. 3.
    Nathan CF, Cohn ZA. Cellular components of inflammation: monocytes and macrophages. In: Kelley W, Harris E, Ruddey S, Hedge R, eds. Textbook of Rheumatology. Philadelphia: Saunders, 1980:144–169.Google Scholar
  4. 4.
    Adams DO, Hamilton TA. Phagocytic cells: cytotoxic activities of macrophages. In: Gallin JI, Goldstein IM, Synder-man R, eds. Inflammation: Basic Principles and Clinical Correlates. New York: Raven Press, 1988:471–492.Google Scholar
  5. 5.
    Unanue ER. Secretory function of mononuclear phagocytes. Am J Pathol 1986; 83:396–417.Google Scholar
  6. 6.
    Rodgers KE, diZerega GS. Function of peritoneal exudate cells after abdominal surgery. J Invest Surg 1993; 6:9–13.PubMedCrossRefGoogle Scholar
  7. 7.
    Clark RA, Klebanoff SJ. Neutrophil-mediated tumor cell cytotoxicity: role of the peroxidase system. J Exp Med 1975; 141:1442–1457.PubMedCrossRefGoogle Scholar
  8. 8.
    Klebanoff SJ. Antimicrobial mechanisms of neutrophilic polymorphonuclear-leukocytes. Semin Hematol 1975; 12:117–124.PubMedGoogle Scholar
  9. 9.
    Nathan CF, Root KA. Hydrogen peroxide release from mouse peritoneal macrophages: dependence on sequential activation and triggering. J Exp Med 1977; 146:1648–1662.PubMedCrossRefGoogle Scholar
  10. 10.
    Fukasawa M, Bryant SM, diZerega GS. Superoxide anion production by postsurgical macrophages. J Surg Res 1988; 45:382–388.PubMedCrossRefGoogle Scholar
  11. 11.
    Kuraoka S, Campeau JD, Nakamura RM, et al. Modulation of postsurgical macrophage function by early postsurgical poly-morphonuclear neutrophils. J Surg Res 1992; 53:245–250.PubMedCrossRefGoogle Scholar
  12. 12.
    Randall RW, Eakins KE, Higgs GA. Inhibition of arachi-donic acid cyclooxygenase and lipo-oxygenase activities by indomethacin and compound BW755. Agents Actions 1980; 10:553–555.PubMedCrossRefGoogle Scholar
  13. 13.
    Schnyder J, Dewald B, Baggiolini M. Effects of cyclooxygenase inhibitors and prostaglandin E2 on macrophage activation in vitro. Prostaglandins 1981; 22:411–419.PubMedCrossRefGoogle Scholar
  14. 14.
    Vanderhock JY, Bailey JM. Activation of a 15-lipoxyge-nase/leukotriene pathway in human polymorphonuclear leukocytes by the anti-inflammatory agent ibuprofen. J Biol Chem 1984; 259:6752–6755.Google Scholar
  15. 15.
    Shimanuki T, Nakamura RM, diZerega GS. A kinetic analysis of peritoneal fluid cytology and arachidonic acid metabolism after abrasion and reabrasion of rabbit peritoneum. J Surg Res 1986; 41:245–251.PubMedCrossRefGoogle Scholar
  16. 16.
    Tsai TJ, Yen CJ, Fang CC, et al. Effect of intraperitoneally administered agents on human peritoneal mesothelial cell growth. Nephron 1995; 71(1):23–28.PubMedCrossRefGoogle Scholar
  17. 17.
    Witowski J, Brebowicz A, Knapowski J, et al. In vitro culture of human peritoneal mesothelium for investigation of mesothelial dysfunction during peritoneal dialysis. J Phys-iol Pharmacol 1994; 45(2):271–284.Google Scholar
  18. 18.
    Chen JY, Yang AH, Lin YP, et al. Absence of modulating effects of cytokines on antioxidant enzymes in peritoneal mesothelial cells. Perit Dial Int 1997; 17(5):455–466.PubMedGoogle Scholar
  19. 19.
    Rooney OB, Odd PD, Gokal R, et al. Dialysis fluid cytotoxi-city and inhibition of host defense in cultured human mesothelial cells are neutralized rapidly with incubation in the peritoneum. Nephrol Dial Transplant 1996; 11(12):2472–2477.PubMedCrossRefGoogle Scholar
  20. 20.
    Berborowicz A, Rodela H, Karon J, et al. In vitro simulation of the effect of peritoneal dialysis solution on mesothelial cells. Am J Kidney Dis 1997; 29(3):404–449.CrossRefGoogle Scholar
  21. 21.
    Kumano K, Ma P, Hyodo T, et al. Effects of osmotic agents on hyaluronan synthesis in human peritoneal mesothelial cells and fibroblasts. Adv Perit Dial 1997; 13:58–63.PubMedGoogle Scholar
  22. 22.
    Yen CJ, Tsai TJ, Chen HS, et al. Effects of intraperitoneal antibiotics on human peritoneal mesothelial cell growth. Nephron 1996; 74(4):694–700.PubMedCrossRefGoogle Scholar
  23. 23.
    Bachus KE, Doty E, Haney AF, et al. Differential effects of interleukin-1 alpha, tumor necrosis factor-alpha, in-domethacin, hydrocortisone, and macrophage co-culture on the proliferation of human fibroblasts and peritoneal mesothelial cells. J Soc Gynecol Invest 1995; 2(4):636–642.CrossRefGoogle Scholar
  24. 24.
    Beavis MJ, Williams JD, Hoppe J, et al. Human peritoneal fibroblast proliferation in 3-dimensional culture: modulation by cytokines, growth factors and peritoneal dialysis effluent. Kidney Int 1997; 51(1):205–215.PubMedCrossRefGoogle Scholar
  25. 25.
    Topley N, Petersen MM, Mackenzie R, et al. Human peritoneal mesothelial cell prostaglandin synthesis: induction of cyclooxygenase mRNA by peritoneal macrophage-de-rived cytokines. Kidney Int 1994; 46(3):900–909.PubMedCrossRefGoogle Scholar
  26. 26.
    Zeillemaker AM, Mul FP, Hoynck van Papendrect AA, et al. Neutrophil adherence to and migration across mono-layers of human peritoneal mesothelial cells. The role of mesothelium in the influx of neutrophils during peritonitis. J Lab Clin Med 1996; 127(3):279–286.PubMedCrossRefGoogle Scholar
  27. 27.
    Arid A, Tazuke SI, Attar E, et al. Interleukin-8 concentration in peritoneal fluid of patients with endometriosis and modulation of interleukin-8 expression in human mesothelial cells. Mol Hum Reprod 1996; 2(1):40–45.CrossRefGoogle Scholar
  28. 28.
    Liberek T, Topley N, Luttmann W, et al. Adherence of neutrophils to human peritoneal mesothelial cells: role of intercellular adhesion molecule-1. J Am Soc Nephrol 1996; 7(2):208–217.PubMedGoogle Scholar
  29. 29.
    Zang Y, Hou F, Zhang X. Effects of epidermal growth factor (EGF) on proliferation of human peritoneal mesothelial cells. Chung-Hua Nei K’o Tsa Chih 1996; 35(2):92–94.PubMedGoogle Scholar
  30. 30.
    Sitter T, Spannagl M, Schiffl H, et al. Imbalance between intraperitoneal coagulation and fibrinolysis during perionitis of CAPD patients: the role of mesothelial cells. Nephrol Dial Transplant 1995; 10(5):677–683.PubMedGoogle Scholar
  31. 31.
    Offner FA, Feichtinger H, Stadlmann S, et al. Transforming growth factor-beta synthesis by human peritoneal mesothelial cells. Induction by interleukin-1. Am J Pathol 1996; 148(5):1679–1688.Google Scholar
  32. 32.
    Douvdevani A, Raport J, Konforty A, et al. Human peritoneal mesothelial cells synthesize IL-1 alpha and beta. Kidney Int 1994; 46(4):993–1001.PubMedCrossRefGoogle Scholar
  33. 33.
    Yung S, Coles GA, Davies M. IL-1 beta, a major stimulator of hyaluronan synthesis in vitro of human peritoneal mesothelial cells: relevance to peritonitis in CAPD. Kidney Int 1996; 50(4):1337–1343.PubMedCrossRefGoogle Scholar
  34. 34.
    Breborowicz A, Korybalska K, Grzybowski A, et al. Synthesis of hyaluronic acid by human peritoneal mesothelial cells: effect of cytokines and dialysate. Perit Dial Int 1996; 16(4):274–278.Google Scholar
  35. 35.
    Offner FA, Obrist P, Stadlmann S, et al. IL-6 secretion by human peritoneal mesothelial and ovarian cancer cells. Cytokine 1995; 7(6):542–547.PubMedCrossRefGoogle Scholar
  36. 36.
    Zeillemaker AM, Mul FP, van Papendrecht AA, et al. Limited influence of the mesothelium on the influx of mono-cytes into the peritoneal cavity. Inflammation 1996; 20(1):87–95.PubMedCrossRefGoogle Scholar
  37. 37.
    Douvdevani A, Einbinder T, Ylzari R, et al. TNF-receptors on human peritoneal mesothelial cells: regulation of receptor levels and shedding by IL-1 alpha and TNF alpha. Kidney Int 1996; 50(1):219–228.PubMedCrossRefGoogle Scholar
  38. 38.
    Arid A, Oral E, Attar E, et al. Monocyte chemotactic pro-tein-1 concentration in peritoneal fluid of women with endometriosis and its modulation of expression in mesothelial cells. Fertil Steril 1997; 67(6):1065–1072.CrossRefGoogle Scholar
  39. 39.
    Visser CE, Tekstra J, Brouwer-Steenbergen JJ, et al. Chemokines produced by mesothelial cells: huGRO-alpha, IP-10, MCP-1 and RANTES. Clin Exp Immunol 1998; 112(2):270–275.PubMedCrossRefGoogle Scholar
  40. 40.
    Whawell SA, Scott-Coombes DM, Vipond MN, et al. Tumor necrosis factor-mediated release of plasminogen activator inhibitor 1 by human peritoneal mesothelial cells. Br J Surg 1994; 81(2):214–216.PubMedCrossRefGoogle Scholar
  41. 41.
    Perfumo F, Altieri P, Degl’Innocenti ML, et al. Effects of peritoneal effluents on mesothelial cells in culture: cell proliferation and extracellular matrix regulation. Nephrol Dial Transplant 1996;ll(9):1903–1909.Google Scholar
  42. 42.
    Muller J, Yoshida T. Interaction of murine peritoneal leukocytes and mesothelial cells: in vitro model system to survey cellular events on serosal membranes during inflammation. Clin Immunol Immunopathol 1995; 75(3):231–238.PubMedCrossRefGoogle Scholar
  43. 43.
    Toh H, Torisu M, Shimura H, et al. In vitro analysis of peritoneal adhesions in peritonitis. J Surg Res 1996; 61(1):250–255.PubMedCrossRefGoogle Scholar
  44. 44.
    Gibson FC III, Onderdonk AB, Kasper DL, et al. Cellular mechanism of intraabdominal abscess formation by Bac-teroidesfmgilis. J Immunol 1998; 160(10):5000–5006.PubMedGoogle Scholar
  45. 45.
    Zeillemaker AM, Hoynck van Papendricht AA, Hart MH, et al. Peritoneal interleukin-8 in acute appendicitis. J Surg Res 1996; 62(2):263–277.CrossRefGoogle Scholar
  46. 46.
    Valle MT, Degl Tnnocenti ML, Bertelli R, et al. Antigen-presenting function of human peritoneum mesothelial cells. Clin Exp Immunol 1995; 101(1):172–176.PubMedCrossRefGoogle Scholar
  47. 47.
    Whawell SA, Thompson JN. Cytokine-induced release of plasminogen activator inhibitor-1 by human mesothelial cells. Eur J Surg 1995; 161(5):315–318.PubMedGoogle Scholar
  48. 48.
    Tietze L, Elbrecht A, Schauerte C, et al. Modulation of pro-and antif ibrinolytic properties of human peritoneal mesothelial cells by transforming growth factor beta 1 (TGF-beta 1), tumor necrosis factor alpha (TNF-alpha) and interleukin 1 beta (IL-1 beta). Thromb Haemostasis 79:362–370.Google Scholar
  49. 49.
    Postlethwaite AE, Lachman LB, Mainadri CL, et al. Inter-leukin-I stimulation of collagenase production by cultured fibroblasts. J Exp Med 1983; 157:801–806.PubMedCrossRefGoogle Scholar
  50. 50.
    Matsushima K, Bano M, Kidwell WR, et al. Interleukin-1 increases collagen type IV production by murine mammary epithelial cells. J Immunol 1985; 134:904–909.PubMedGoogle Scholar
  51. 51.
    Bronson RE, Bertiolami CN, Siebert EP. Modulation of fi-broblast growth and glycosaminoglycan synthesis by interleukin-1. Collagen Relat Res 1987; 7:323–332.CrossRefGoogle Scholar
  52. 52.
    Bevilacqua MP, Pober JS, Majeau GR, et al. Interleukin-1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J Exp Med 1984; 160:618–623.PubMedCrossRefGoogle Scholar
  53. 53.
    Bevilacqua MP, Schleef RR, Gimbrone MA, et al. Regulation of fibrinolytic system of cultured human vascular en-dothelium by interleukin 1. J Clin Invest 1986; 73:587–591.CrossRefGoogle Scholar
  54. 54.
    Emeis JJ, Kooestra J. Interleukin-1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells. J Exp Med 1986; 163:1260–1266.PubMedCrossRefGoogle Scholar
  55. 55.
    Nachman RL, Hajjar KA, Silverstein RL, et al. Interleukin-1 induces endothelial cell synthesis of plasminogen activator inhibitor. J Exp Med 1986; 163:1545–1547.CrossRefGoogle Scholar
  56. 56.
    Nawroth PP, Stem DM. Modulation of endothelial cell he-mostatic properties by tumor necrosis factor. J Exp Med 1986; 163:740–745.PubMedCrossRefGoogle Scholar
  57. 57.
    McBride WH, Mason K, Withers HR, et al. Effect of interleukin-1, inflammation, and surgery on the incidence of adhesion formation after abdominal irradiation in mice. Cancer Res 1988; 49:169–173.Google Scholar
  58. 58.
    Herschlag A, Herness IGO, Wimberly HC, et al. The effect of interleukin-1 on adhesion formation in the rat. Am J Obstet Gynecol 1991; 165:771–774.Google Scholar
  59. 59.
    Abe H, Rodgers KE, Ellefson D, et al. Kinetics of interleukin-1 and tumor necrosis factor by rabbit macrophages recovered from the peritoneal cavity after surgery. J Invest Surg 1991; 4:141–151.PubMedCrossRefGoogle Scholar
  60. 60.
    Abe H, Rodgers KE, Ellefson D, et al. Kinetics of interleukin-1 secretion by murine macrophages recovered from the peritoneal cavity after surgery. J Surg Res 1989; 47:178–182.PubMedCrossRefGoogle Scholar
  61. 61.
    Ko SD, Page RC, Narayanan AS. Fibroblast heterogeneity and prostaglandin regulation of subpopulation. Proc Natl Acad Sci USA 1977; 74:3429–3440.PubMedCrossRefGoogle Scholar
  62. 62.
    Phan SH, McGarry BM, Loeffler KM, et al. Regulation of macrophage derived fibroblast growth factor release by arachidonate metabolites. J Leukocyte Biol 1987; 42:106–113.PubMedGoogle Scholar
  63. 63.
    Korn JH, Halushka PV, LeRoy EC. Mononuclear cell modulation of connective tissue function: suppression of fibroblast growth by stimulation of endogenous prostaglandin production.J Clin Invest 1980; 65:543–554.PubMedCrossRefGoogle Scholar
  64. 64.
    Alexander P, Evans R. Endotoxin and double stranded RNA render macrophages cytotoxic. Nature (Lond) 1971; 232:76–79.Google Scholar
  65. 65.
    Hibbs JB, Lambert LH, Remington JS. In vitro nonim-munologic destruction of cells with abnormal characteristics by adjuvant activated macrophages. Proc Soc Exp Biol Med 1972; 139:1049–1055.PubMedGoogle Scholar
  66. 66.
    Adams DO, Marino P. Activation of mononuclear phagocytes for destruction of tumor cells as a model for the study of macrophage development. In Gordon AS, Silver R, LoBue J, eds. Contemporary Topics in Hematology Oncology. New York: Plenum Press, 1984:69–136.Google Scholar
  67. 67.
    Adams DO, Johnson WJ, Marino PJ. Mechanisms of target recognition and destruction in macrophage mediated tumor cytotoxicity. Fed Proc 1982; 41:2212–2221.PubMedGoogle Scholar
  68. 68.
    Adams DO, Nathan CF. Molecular mechanisms in tumor-cell killing by activated macrophages. Immunol Today 1983; 4:166–170.CrossRefGoogle Scholar
  69. 69.
    Rodgers KE, Ellefson D, Girgis W, et al. Effects of tolmetin sodium dehydrate on normal and postsurgical cell function. Int J Immunopharmacol 1988; 10:111–120.PubMedCrossRefGoogle Scholar
  70. 70.
    Jones PA, Werb Z. Degradation of connective tissue matrices by macrophages. III. Influence of matrix composition on proteolysis of glycoprotein, elastin and collagen by macrophages in culture. J Exp Med 1980; 152:1527–1536.PubMedCrossRefGoogle Scholar
  71. 71.
    Werb Z, Banda MJ, Jones PA. Degradation of connective tissue matrices by macrophages. I. Proteolysis of elastin, glycoproteins and collagen by proteinases isolated from macrophages. J Exp Med 1980; 152:1340–1357.PubMedCrossRefGoogle Scholar
  72. 72.
    Laub R, Huybrechts-Godin G, Peeters-Joris C, et al. Degradation of collagen and proteoglycan by macrophages and fibroblasts. Biochim Biophys Acta 1982; 721:425–433.PubMedCrossRefGoogle Scholar
  73. 73.
    Unkeless J, Gordon S, Reich E. Secretion of plasminogen activator by stimulated macrophages. J Exp Med 1974; 139:834–850.PubMedCrossRefGoogle Scholar
  74. 74.
    Orita H, Campeau JD, Gale JA, et al. Differential secretion of plasminogen activator activity by postsurgical activated macrophages. J Surg Res 1986; 41:569–573.PubMedCrossRefGoogle Scholar
  75. 75.
    Fukasawa M, Campeau JD, Girgis W, et al. Production of protease inhibitors by postsurgical macrophages. J Surg Res 1989: 46:256–261.PubMedCrossRefGoogle Scholar
  76. 76.
    Kuraoka S, Campeau JD, Rodgers KE, et al. Effects of interleukin 1 on postsurgical macrophage secretion of protease and protease inhibitor activates. J Surg Res 1992; 52:71–78.PubMedCrossRefGoogle Scholar
  77. 77.
    Diegelmann RF, Cohen IK, Kaplan AM. The role of macrophages in wound repair: a review. Plast Reconstr Surg 1981; 68:107–113.PubMedCrossRefGoogle Scholar
  78. 78.
    Raftery AT. Regeneration of parietal and visceral peritoneum. Br J Surg 1973; 60:293–299.PubMedCrossRefGoogle Scholar
  79. 79.
    Raftery AT. Regeneration of parietal and visceral peritoneum in the immature animal. Br J Surg 1973; 60:969–975.PubMedCrossRefGoogle Scholar
  80. 80.
    Fukasawa M, Bryant SM, Nakamura RM, et al. Modulation of fibroblast proliferation by postsurgical macrophages. J Surg Res 1987; 43:513–520.PubMedCrossRefGoogle Scholar
  81. 81.
    Fukasawa M, Campeau JD, Yanagihara DL, et al. Mitogenic and protein synthetic activity of tissue repair cells: control by the postsurgical macrophage. J Invest Surg 1989; 2:169–180.PubMedCrossRefGoogle Scholar
  82. 82.
    Fukasawa M, Yanagihara DL, Rodgers KE, et al. The mitogenic activity of peritoneal tissue repair cells: control by growth factors. J Surg Res 1989; 47:45–51.PubMedCrossRefGoogle Scholar
  83. 83.
    Fukasawa M, Bryant SM, diZerega GS. Incorporation of thymidine by fibroblasts: evidence for complex regulation by postsurgical macrophages. J Surg Res 1988; 45:460–466.PubMedCrossRefGoogle Scholar
  84. 84.
    Rodgers KE, diZerega GS. Modulation of peritoneal re-ep-ithelialization by postsurgical macrophages. J Surg Res 1992; 53:542–548.PubMedCrossRefGoogle Scholar
  85. 85.
    Ryan GG, Grobety J, Majno G. Mesothelial injury and recovery. Am J Pathol 1973; 71:93–112.PubMedGoogle Scholar
  86. 86.
    Bryant SM, Fukasawa M, Orita H, et al. Mediation of post-surgical wound healing by macrophages. In: Growth Factors and Other Aspects of Wound Healing. Biological and Clinical Implications. New York: Liss, 1988:263–290.Google Scholar
  87. 87.
    Martin BM, Gimbrone MA Jr., Unanue ER, et al. Stimulation of nonlymphoid mesenchymal cell proliferation by a macrophage-derived growth factor. J Immunol 1981; 126:1510–1515.PubMedGoogle Scholar
  88. 88.
    Tsukamoto Y, Helsen WE, Wahl SM. Macrophage production of fibronectin. A chemoattractant for fibroblast. J Immunol 1981; 127:673–678.PubMedGoogle Scholar
  89. 89.
    Postlethwaite AE, Kang AH. Induction of fibroblast proliferation by human mononuclear derived proteins. Arthritis Rheum 1983; 26:22–27.PubMedCrossRefGoogle Scholar
  90. 90.
    Gosline JM, Rosenbloom J. Elastin. In: Piez KA, Reddi AH, eds. Extracellular Matrix Biochemistry. New York: El-sevier, 1984:191–227.Google Scholar
  91. 91.
    Samuelson B, Branstrom E, Greek K, et al. Prosta-glandins. Annu Rev Biochem 1971; 44:669–692.CrossRefGoogle Scholar
  92. 92.
    Opitz HG, Niethammer D, Lemk H, et al. Inhibition of 3H-thymidine incorporation of lymphocytes by a soluble factor from macrophages. Cell Immunol 1975; 16:379–388.PubMedCrossRefGoogle Scholar
  93. 93.
    Gresser J, Brouty-Boye K, Thomas MG, et al. Interferon and cell division I. Inhibition of the multiplication of mouse leukemia C12 106/B in vitro by interferon preparations. Proc Natl Acad Sci USA 1970; 66:1052–1058.PubMedCrossRefGoogle Scholar
  94. 94.
    Kung JT, Brooks SB, Jakway JB, et al. Suppression of in vitro cytotoxic response by macrophage due to induced arginase. J Exp Med 1977; 146:665–680.PubMedCrossRefGoogle Scholar
  95. 95.
    Harris A, Dunn G. Centripetal transport of attached pep-tides on both surfaces of moving fibroblasts. Exp Cell Res 1972; 73:519–523.PubMedCrossRefGoogle Scholar
  96. 96.
    Prydze HA, Allison AC, Schlorlemner HU. Further link between complement activation and coagulation. Nature (Lond) 1977; 270:173–178.CrossRefGoogle Scholar
  97. 97.
    Abercrombie M, Heaysman JEM, Pegrum SM. The locomotion of f ibroblasts in culture. IV. Electron microscopy of the leading lamella. Exp Cell Res 1971; 67:359–367.PubMedCrossRefGoogle Scholar
  98. 98.
    Lemke H, Huget R, Flad HD. Biochemical characterization of a factor released by macrophages. Cell Immunol 1975; 18:70–75.PubMedCrossRefGoogle Scholar
  99. 99.
    Leibovich SJ, Ross R. A macrophage-dependent factor that stimulates the proliferation of fibroblast in vitro. Am J Pathol 1976; 84:501–508.PubMedGoogle Scholar
  100. 100.
    Leibovich SJ. Production of macrophage-dependent fibroblast-stimulating activity (M-FSA) by murine macrophages. Exp Cell Res 1978; 113:47–53.PubMedCrossRefGoogle Scholar
  101. 101.
    Bitterman PB, Rennard SI, Hunninghake GW, et al. Human alveolar macrophage growth factor regulation and partial characterization. J Clin Invest 1982; 70:806–822.PubMedCrossRefGoogle Scholar
  102. 102.
    Takemura R, Werb Z. Secretory products of macrophages and their physiological functions. Am J Physiol 1984;246:C1–C9.PubMedGoogle Scholar
  103. 103.
    Bleiberg I, Harvey AK, Smale G, et al. Identification of a PDGF-like chemoattractant produced by NIH/3T3 cells after transformation with SV40. J Cell Biol 1985; 123:161–166.Google Scholar
  104. 104.
    Jimenez de Asua L, Clingan D, Rudland PS. Initiation of cell proliferation in cultured mouse fibroblasts by prostaglandin Fa. Proc Natl Acad Sci USA 1975; 72:2724–2728.CrossRefGoogle Scholar
  105. 105.
    Jimenez de Asua LL, Otto AM, Lingren J, et al. The stimulation of the initiation of DNA synthesis and cell division in Swiss mouse 3T3 cells by prostaglandin Fa requires specific functional groups in the molecule. J Biol Chem 1983; 258:8774–8777.Google Scholar
  106. 106.
    Mizel SB, Dayer JM, Krane SM, et al. Stimulation of rheumatoid synovial cell collagenase and prostaglandin production by partially purified lymphocyte activating factor. Proc Natl Acad Sci USA 1981; 78:2474–2477.PubMedCrossRefGoogle Scholar
  107. 107.
    Calderon J, Williams RT, Unanue ER. An inhibitor of cell proliferation related by cultures of macrophages. Proc Natl Acad Sci USA 1974; 71:4273–4277.PubMedCrossRefGoogle Scholar
  108. 108.
    Carpenter G. Vanadate epidermal growth factor and the stimulation of DNA synthesis. Biochem Biophys Res Commun. 1981; 102:1115–1121.PubMedCrossRefGoogle Scholar
  109. 109.
    Schmidt JA, Mizel SB, Cohen D, et al. Interleukin-1, a potential regulator of fibroblast proliferation. J Immunol 1982; 128:2177–2192.PubMedGoogle Scholar
  110. 110.
    Orita H, Campeau JD, Nakamura RM, et al. Modulation of fibroblast proliferation by post-surgical macrophages: a time and dose-response study during postsurgical peritoneal re-epithelialization. Am J Obstet Gynecol 1986; 155:905–911.PubMedGoogle Scholar
  111. 111.
    Roberts AB, Anzano MA, Wakefield LM, et al. Type ß transforming growth factor: a bidirectional regulation of cell growth. Proc Natl Acad Sci USA 1985; 82:119–123.PubMedCrossRefGoogle Scholar
  112. 112.
    Cohen S, Carpenter G. Human epidermal growth factor: isolation and chemical and biological properties. Proc Natl Acad Sci USA 1975; 72:1317–1323.PubMedCrossRefGoogle Scholar
  113. 113.
    Ross R, Bowen-Pope DF. Platelet derived growth factor. J Clin Endocrinol Metab 1984; 13:191–199.CrossRefGoogle Scholar
  114. 114.
    Baird A, Esch F, Mormede P, et al. Molecular characteristics of fibroblast growth factors distribution and biological activities in various tissues. Recent Prog Horm Res 1986; 42:143–205.PubMedGoogle Scholar
  115. 115.
    Baird A, Mormede P, Bohlen P. Immunoreactive fibroblast growth factor in cells of peritoneal exudate suggest its identity with macrophage derived growth factor. Biochem Biophys Res Commun 1985; 126:358–364.PubMedCrossRefGoogle Scholar
  116. 116.
    Ignotz RA, Massaque J. Transforming growth factor ß stimulates the expression of fibronectin and collagen and their incorporation into the extracellular matrix. J Biol Chem 1986; 261:4337–4345.PubMedGoogle Scholar
  117. 117.
    Simpson DM, Ross R. The neutrophilic leukocyte in wound repair. A study with anti-neutrophil serum. J Clin Invest 1972; 51:2009–2023.PubMedCrossRefGoogle Scholar
  118. 118.
    Leibovich SJ, Ross R. The role of macrophages in wound repair. A study with hydrocortisone and anti-macrophage serum. Am J Pathol 1975; 78:71–100.PubMedGoogle Scholar
  119. 119.
    Seppae H, Grotendorst G, Seppae S, et al. Platelet derived growth factor is chemotactic for fibroblasts. J Cell Biol 1982; 92:584–588.CrossRefGoogle Scholar
  120. 120.
    Shimakado K, Raines EW, Madtes DK, et al. A significant part of macrophage derived growth factor consists of at least two forms of PDGF cell. Cell 1985; 43:277–286.CrossRefGoogle Scholar
  121. 121.
    Cohen S. Isolation of a mouse submaxillary gland protein accelerating incisor eruption and eyelid opening in the newborn animal. J Biol Chem 1962; 237:1555–1568.PubMedGoogle Scholar
  122. 122.
    Clemmons DR, Underwood LE, Van Wyk JJ. Hormonal control of immunoreactive somatomedin production by cultured human fibroblasts. J Clin Invest 1981; 64:10–19.CrossRefGoogle Scholar
  123. 123.
    Assoian RK, Kornoriya A, Meyers CA, et al. Transforming growth factor-ß in human platelets. J Biol Chem 1983; 258:7155–7160.PubMedGoogle Scholar
  124. 124.
    Assoian RK, Fleurdelys BE, Stevenson HC, et al. Expression secretion of type ß transforming growth factor by activated human macrophage. Proc Natl Acad Sci USA 1987; 84:6020–6024.PubMedCrossRefGoogle Scholar
  125. 125.
    Cromack DT, Sporn MB, Roberts AB, et al. Transforming growth factor ß levels in rat wound chambers. J Surg Res 1987; 42:622–628.PubMedCrossRefGoogle Scholar
  126. 126.
    Dinarello CA, Cannon JG, Mier JW, et al. Multiple biological activities of human recombinant interleukin 1. J Clin Invest 1986; 77:1734–1739.PubMedCrossRefGoogle Scholar
  127. 127.
    Postlethwaite AE, Lachman LB, Rang AH. Induction of fi-broblast proliferation by interleukin-I derived from human monocytic leukemia cells. Arthritis Rheum 1984; 27:1001–1011.CrossRefGoogle Scholar
  128. 128.
    Fukasawa M, Campeau JD, Yanighihara DL, et al. Regulation of proliferation of peritoneal tissue repair cells by peritoneal macrophages. J Surg Res 1990; 49:81–87.PubMedCrossRefGoogle Scholar
  129. 129.
    Pledger WJ, Stiles CD, Antoniades HN, et al. An ordered sequence of events is required before BALB/c-3T3 cells have become committed to DNA synthesis. Proc Natl Acad Sci USA 1987; 74:2839–2848.Google Scholar
  130. 130.
    Abercrombie M, Heaysman JEM, Pegrum SM. Locomotion of fibroblasts in culture. V. Surface marking with concanavilin A. Exp Cell Res 1972; 3:536–539.CrossRefGoogle Scholar
  131. 131.
    Postlethwaite AE, Keski-Oja J, Moses HL, et al. Stimulation of the chemotactic migration of human fibroblasts by transforming growth factor. J Exp Med 1987; 165:251–256.PubMedCrossRefGoogle Scholar
  132. 132.
    Barbul A, Knud-Hansen J, Wasserkrug HL, et al. Inter-leukin-2 enhances wound healing in rats. J Surg Res 1986; 40:315–319.PubMedCrossRefGoogle Scholar
  133. 133.
    Kleinman HK, McGoodwin EB, Klebe RJ. Localization of the cell attachment region in types I and II collagen. Biochem Biophys Res Commun 1976; 72:426–432.PubMedCrossRefGoogle Scholar
  134. 134.
    Kleinman HK, Klebe RJ, Martin GR. Role of collagenous matrices in adhesion and growth of cells. J Cell Biol 1981; 88:473–485.PubMedCrossRefGoogle Scholar
  135. 135.
    Assoian RK. Biphasic effect of type ß transforming growth factor on epidermal growth factor receptors in NRK fibroblasts: functional consequences for epidermal growth factor stimulated mitosis. J Biol Chem 1986; 260:9613–9617.Google Scholar
  136. 136.
    Sporn MB, Roberts AB, Shull JH, et al. Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo. Science 1983; 219:1329–1331.PubMedCrossRefGoogle Scholar
  137. 137.
    Mensing H, Czametozki BM. Leukotriene B induces in vitro fibroblast chemotaxis. J Invest Dermatol 1984; 82:9–12.PubMedCrossRefGoogle Scholar
  138. 138.
    Thalacker FW, Nilsen-Hamilton M. Specific induction of secreted proteins by transforming growth factor and 12-O-tetra-decanoyl phorbol-13-acetate. J Biol Chem 1987; 262:2288–2290.Google Scholar
  139. 139.
    Varga J, Jimenez SA. Stimulation of normal human fibroblast collagen production and processing by transforming growth factor-ß and 12-O-tetradecanoyl phorbol-I 3-acetate. J Biol Chem 1987; 262:2283–2287.Google Scholar
  140. 140.
    Wahl SM, McCartney-Francis N, Mergenhagen SE. Inflammatory and immunoregulatory roles of TGF-ß. Immunol Today 1989; 10:258–261.PubMedCrossRefGoogle Scholar
  141. 141.
    Vipond MN, Whawell SA, Thompson JN, et al. Peritoneal fibrinolytic activity and intra-abdominal adhesions. Lancet 1990; 335:1120–1122.PubMedCrossRefGoogle Scholar
  142. 142.
    van der Poll T, Levi M, Buller HR, et al. Fibrinolytic response to tumor necrosis factor in healthy subjects. J Exp Med 1991; 175:729–732.CrossRefGoogle Scholar
  143. 143.
    Gervin AS, Puckett CL, Silver D. Serosal hypofibrinolysis. A cause of postoperative adhesions. Am J Surg 1973; 125:80–88.PubMedCrossRefGoogle Scholar
  144. 144.
    Raftery AT. Effect of peritoneal trauma on peritoneal fibrinolytic activity and intraperitoneal adhesion formation. Eur Surg Res 1981; 13:397–401.PubMedCrossRefGoogle Scholar
  145. 145.
    Buckman RFJr, Maj MC, Buckman PD, et al. A physiologic basis for the adhesion-free healing of deperitoneal-ized surfaces. J Surg Res 1976; 21:67–76.PubMedCrossRefGoogle Scholar
  146. 146.
    van Hinsbergh VWM, Kooistra T, Scheffer MA, et al. Characterization and fibrinolytic properties of human omental tissue mesothelial cells. Comparison with en-dothelial cells. Blood 1990; 75:1490–1497.Google Scholar
  147. 147.
    Hau T, Payne D, Simmons RL. Fibrinolytic activity of the peritoneum during experimental peritonitis. Surg Gy-necol Obstet 1979; 148:415–418.Google Scholar
  148. 148.
    diZerega GS, Rodgers KE. Tissue repair cells In: The Peritoneum. New York: Springer-Verlag, 1992:58.Google Scholar

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© Springer Science+Business Media New York 2000

Authors and Affiliations

  • Kathleen E. Rodgers

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