Growth Hormone: The Visible Difference in Burn Care

  • Michael J. Muller
  • Thomas C. Rutan
  • David N. Herndon
Conference paper
Part of the Serono Symposia USA book series (SERONOSYMP)


The response to a large burn is characterized by increased basal metabolic rate, elevated core temperature, hyperdynamic circulation, protein catabolism, futile substrate cycling, marked lipolysis, loss of lean body mass, increased susceptibility to infection, and poor wound healing. This is known as the stress response, and the nervous system plays a major role in its pathophysiology (1-14). The limbic system is activated by fear, emotion, and thalamic relay of peripheral nocioceptive stimuli (15). Inflammatory mediators and various cytokines, such as bacterial endotoxin, interleukin-1, and tumor necrosis factor a, stimulate the hypothalamus directly (16-20). They increase the thermoregulatbry set point and alter endocrine function (21-23).


Growth Hormone Human Growth Hormone Growth Hormone Treatment Recombinant Human Growth Hormone Protein Anabolism 
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Copyright information

© Springer Science+Business Media New York 1995

Authors and Affiliations

  • Michael J. Muller
  • Thomas C. Rutan
  • David N. Herndon

There are no affiliations available

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