Skip to main content

Polymeric Drug Delivery Systems

  • Chapter
Idea to Product

Part of the book series: Serono Symposia USA ((SERONOSYMP))

  • 88 Accesses

Abstract

In this chapter, we discuss two areas of our research. The first of these involves discoveries we made involving the use of polymers for the release of large molecules. The second involves the synthesis of a new family of degradable polymers-polyanhydrides. In both cases we examine the ideas involved, the initial research, and the eventual consequences of the research.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Gimbrone MA Jr, Contran RS, Leapman SB, Folkman J. Tumor growth and neovascularization: An experimental model using rabbit cornea. J Natl Cancer Inst 1974;52:413–27.

    PubMed  Google Scholar 

  2. Davis BK. Diffusion in polymer gel implants. Proc Natl Acad Sci USA 1974;71:3120–3.

    Article  PubMed  CAS  Google Scholar 

  3. Langer R, Folkman J. Polymers for the sustained release of proteins and other macromolecules. Nature 1976;263:797–800.

    Article  PubMed  CAS  Google Scholar 

  4. Langer R, Brem H, Tapper D. Biocompatibility of polymeric delivery systems for macromolecules. J Biomed Mat Res 1981;15:267–77.

    Article  CAS  Google Scholar 

  5. Rhine W, Hsieh DST, Langer R. Polymers for sustained macromolecule release: Procedures to fabricate reproducible delivery systems and control release kinetics. J Pharm Sci 1980;69:265–70.

    Article  PubMed  CAS  Google Scholar 

  6. Langer RS, Folkman J. Sustained release of macromolecules from polymers. In: Kostelnik RJ, editor. Polymeric delivery systems. Midland Macromolecular Monograph. New York: Gordon & Breach, 1978;5:175–96.

    Google Scholar 

  7. Polverini P, Cotran R, Gimbrone M, Unanue E. Activated macromophages induce vascular proliferation. Nature 1977;269:804–6.

    Article  PubMed  CAS  Google Scholar 

  8. Schor AM, Schor SL, Kumar S. Importance of a collagen substratum for stimulation of capillary endothelial cell proliferation by tumor angiogenesis factor. Int J Cancer 1979;24:225–34.

    Article  PubMed  CAS  Google Scholar 

  9. Bawa R, Siegel R, Marasca B, Karel M, Langer R. An explanation for the sustained release of macromolecules from polymers. J Controlled Release 1985;1:259–67.

    Article  CAS  Google Scholar 

  10. Cohen S, Yoshioka T, Lucarelli M, Hwang LH, Langer R. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharm Res 1991;8:713–20.

    Article  PubMed  CAS  Google Scholar 

  11. Langer R, Fefferman M, Gryska P, Bergman K. A simple method for studying chemotaxis using sustained release of attractants from inert polymers. Can J Microbiol 1980;26:274–8.

    Article  PubMed  CAS  Google Scholar 

  12. Brown L, Siemer L, Munoz C, Edelman E, Langer R. Controlled release of insulin from polymer matrices: control of diabetes in rats. Diabetes 1986;35:6927.

    Google Scholar 

  13. Preis I, Langer R. A single step immunization by sustained antigen release. J Immunol Methods 1979;28:193–7.

    Article  PubMed  CAS  Google Scholar 

  14. Simons M, Edelman ER, DeKeyser JL, Langer R, Rosenberg RD. Antisense c-myb oligonucleotides inhibit arterial smooth muscle proliferation in vivo. Nature 1992;359:67–70.

    Article  PubMed  CAS  Google Scholar 

  15. Levy RJ, Wolfrum J, Schoen F, Hawley M, Lund SA, Langer R. Inhibition of calcification of bioprosthetic heart valves by local controlled release diphosphonate. Science 1985;228:190–2.

    Article  PubMed  CAS  Google Scholar 

  16. During MJ, Freese A, Sabel BA, Saltzman WM, Deutch A, Roth RH, Langer R. Controlled release of dopamine from a polymeric brain implant: in vivo characterization. Ann Neur 1989;25:351–6.

    Article  CAS  Google Scholar 

  17. Heller J. Controlled release of biologically active compounds from bio-erodible polymers. Biomaterials 1980;1:51–8.

    Article  PubMed  CAS  Google Scholar 

  18. Rosen HG, Chang J, Wnek G, Linhardt R, Langer R. Bioerodible polyanhydrides for controlled drug delivery. Biomaterials 1983;4:131–3.

    Article  PubMed  CAS  Google Scholar 

  19. Leong KW, Brott BC, Langer R. Bioerodible polyanhydrides as drug-carrier matrices: I: Characterization, degradation and release characteristics. J Biomed Mat Res 1985;19:941–55.

    CAS  Google Scholar 

  20. Leong KW, D’Amore P, Marletta M, Langer R. Bioerodible polyanhydrides as drug-carrier matrices: II: Biocompatibility and chemical reactivity. J Biomed Mat Res 1986;20:51–64.

    CAS  Google Scholar 

  21. Leong KW, Simonte V, Langer R. Synthesis of polyanhydrides: Melt-polycondensation, dehydrochlorination, and dehydrative coupling. Macromolecules 1987;20:705–12.

    Article  CAS  Google Scholar 

  22. Domb A, Langer R. Polyanhydrides: I. Preparation of high molecular weight polyanhydrides. J Polymer Sci 1987;25:3373–86.

    CAS  Google Scholar 

  23. Grossman SA, Reinhard C, Colvin OM, Chasin M, Brundrett R, Tamargo RJ, Brem H. The intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers. J Neurosurg 1992;76:640–7.

    Article  PubMed  CAS  Google Scholar 

  24. Tamargo RJ, Epstein JI, Reinhard CS, Chasin M, Brem H. Brain biocompatibility of a biodegradable controlled-release polymer in rats. J Biomed Mater Res 1988;23:253–66.

    Article  Google Scholar 

  25. Brem H, Kader A, Epstein JI, Tamargo RJ, Domb A, Langer R, et al. Biocompatibility of a biodegradable, controlled-release polymer in the rabbit brain. Sel Cancer Ther 1989;5:55–65.

    Article  PubMed  CAS  Google Scholar 

  26. Brem H, Ahn H, Tamargo RJ, Domb A, Langer R, Leong KW. A biodegradable polymer for intracranial drug delivery: A radiological study in primates. Toronto: American Association of Neurological Surgeons, 1988;349.

    Google Scholar 

  27. Laurencin C, Domb A, Morris C, Brown V, Chasin M, McConnell R, et al. Poly(anhydride) administration in high doses in vivo: Studies of biocompatibility and toxicology. J Biomed Mat Res 1990;1463–81.

    Google Scholar 

  28. Tamargo RJ, Myseros JS, Epstein JI, Yang MB, Chasin M, Brem H. Interstitial chemotherapy of the 9L gliosarcoma: Controlled release polymers for drug delivery in the brain. Cancer Res 1993;53:329–33.

    PubMed  CAS  Google Scholar 

  29. Brem H, Mahaley S, Vick NA, Black KL, Schold C, Burger PC, et al. Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas. J Neurosurg 1991;74:441–6.

    Article  PubMed  CAS  Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1996 Springer Science+Business Media New York

About this chapter

Cite this chapter

Langer, R.S. (1996). Polymeric Drug Delivery Systems. In: Alexander, N.J., Wentz, A.C. (eds) Idea to Product. Serono Symposia USA. Springer, New York, NY. https://doi.org/10.1007/978-1-4612-0743-6_11

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-0743-6_11

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4612-6889-5

  • Online ISBN: 978-1-4612-0743-6

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics