Polymeric Drug Delivery Systems

  • Robert S. Langer
Part of the Serono Symposia USA book series (SERONOSYMP)


In this chapter, we discuss two areas of our research. The first of these involves discoveries we made involving the use of polymers for the release of large molecules. The second involves the synthesis of a new family of degradable polymers-polyanhydrides. In both cases we examine the ideas involved, the initial research, and the eventual consequences of the research.


Polylactic Acid Release Kinetic Rabbit Cornea Phone Book Polymer Erosion 
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  1. 1.
    Gimbrone MA Jr, Contran RS, Leapman SB, Folkman J. Tumor growth and neovascularization: An experimental model using rabbit cornea. J Natl Cancer Inst 1974;52:413–27.PubMedGoogle Scholar
  2. 2.
    Davis BK. Diffusion in polymer gel implants. Proc Natl Acad Sci USA 1974;71:3120–3.PubMedCrossRefGoogle Scholar
  3. 3.
    Langer R, Folkman J. Polymers for the sustained release of proteins and other macromolecules. Nature 1976;263:797–800.PubMedCrossRefGoogle Scholar
  4. 4.
    Langer R, Brem H, Tapper D. Biocompatibility of polymeric delivery systems for macromolecules. J Biomed Mat Res 1981;15:267–77.CrossRefGoogle Scholar
  5. 5.
    Rhine W, Hsieh DST, Langer R. Polymers for sustained macromolecule release: Procedures to fabricate reproducible delivery systems and control release kinetics. J Pharm Sci 1980;69:265–70.PubMedCrossRefGoogle Scholar
  6. 6.
    Langer RS, Folkman J. Sustained release of macromolecules from polymers. In: Kostelnik RJ, editor. Polymeric delivery systems. Midland Macromolecular Monograph. New York: Gordon & Breach, 1978;5:175–96.Google Scholar
  7. 7.
    Polverini P, Cotran R, Gimbrone M, Unanue E. Activated macromophages induce vascular proliferation. Nature 1977;269:804–6.PubMedCrossRefGoogle Scholar
  8. 8.
    Schor AM, Schor SL, Kumar S. Importance of a collagen substratum for stimulation of capillary endothelial cell proliferation by tumor angiogenesis factor. Int J Cancer 1979;24:225–34.PubMedCrossRefGoogle Scholar
  9. 9.
    Bawa R, Siegel R, Marasca B, Karel M, Langer R. An explanation for the sustained release of macromolecules from polymers. J Controlled Release 1985;1:259–67.CrossRefGoogle Scholar
  10. 10.
    Cohen S, Yoshioka T, Lucarelli M, Hwang LH, Langer R. Controlled delivery systems for proteins based on poly(lactic/glycolic acid) microspheres. Pharm Res 1991;8:713–20.PubMedCrossRefGoogle Scholar
  11. 11.
    Langer R, Fefferman M, Gryska P, Bergman K. A simple method for studying chemotaxis using sustained release of attractants from inert polymers. Can J Microbiol 1980;26:274–8.PubMedCrossRefGoogle Scholar
  12. 12.
    Brown L, Siemer L, Munoz C, Edelman E, Langer R. Controlled release of insulin from polymer matrices: control of diabetes in rats. Diabetes 1986;35:6927.Google Scholar
  13. 13.
    Preis I, Langer R. A single step immunization by sustained antigen release. J Immunol Methods 1979;28:193–7.PubMedCrossRefGoogle Scholar
  14. 14.
    Simons M, Edelman ER, DeKeyser JL, Langer R, Rosenberg RD. Antisense c-myb oligonucleotides inhibit arterial smooth muscle proliferation in vivo. Nature 1992;359:67–70.PubMedCrossRefGoogle Scholar
  15. 15.
    Levy RJ, Wolfrum J, Schoen F, Hawley M, Lund SA, Langer R. Inhibition of calcification of bioprosthetic heart valves by local controlled release diphosphonate. Science 1985;228:190–2.PubMedCrossRefGoogle Scholar
  16. 16.
    During MJ, Freese A, Sabel BA, Saltzman WM, Deutch A, Roth RH, Langer R. Controlled release of dopamine from a polymeric brain implant: in vivo characterization. Ann Neur 1989;25:351–6.CrossRefGoogle Scholar
  17. 17.
    Heller J. Controlled release of biologically active compounds from bio-erodible polymers. Biomaterials 1980;1:51–8.PubMedCrossRefGoogle Scholar
  18. 18.
    Rosen HG, Chang J, Wnek G, Linhardt R, Langer R. Bioerodible polyanhydrides for controlled drug delivery. Biomaterials 1983;4:131–3.PubMedCrossRefGoogle Scholar
  19. 19.
    Leong KW, Brott BC, Langer R. Bioerodible polyanhydrides as drug-carrier matrices: I: Characterization, degradation and release characteristics. J Biomed Mat Res 1985;19:941–55.Google Scholar
  20. 20.
    Leong KW, D’Amore P, Marletta M, Langer R. Bioerodible polyanhydrides as drug-carrier matrices: II: Biocompatibility and chemical reactivity. J Biomed Mat Res 1986;20:51–64.Google Scholar
  21. 21.
    Leong KW, Simonte V, Langer R. Synthesis of polyanhydrides: Melt-polycondensation, dehydrochlorination, and dehydrative coupling. Macromolecules 1987;20:705–12.CrossRefGoogle Scholar
  22. 22.
    Domb A, Langer R. Polyanhydrides: I. Preparation of high molecular weight polyanhydrides. J Polymer Sci 1987;25:3373–86.Google Scholar
  23. 23.
    Grossman SA, Reinhard C, Colvin OM, Chasin M, Brundrett R, Tamargo RJ, Brem H. The intracerebral distribution of BCNU delivered by surgically implanted biodegradable polymers. J Neurosurg 1992;76:640–7.PubMedCrossRefGoogle Scholar
  24. 24.
    Tamargo RJ, Epstein JI, Reinhard CS, Chasin M, Brem H. Brain biocompatibility of a biodegradable controlled-release polymer in rats. J Biomed Mater Res 1988;23:253–66.CrossRefGoogle Scholar
  25. 25.
    Brem H, Kader A, Epstein JI, Tamargo RJ, Domb A, Langer R, et al. Biocompatibility of a biodegradable, controlled-release polymer in the rabbit brain. Sel Cancer Ther 1989;5:55–65.PubMedCrossRefGoogle Scholar
  26. 26.
    Brem H, Ahn H, Tamargo RJ, Domb A, Langer R, Leong KW. A biodegradable polymer for intracranial drug delivery: A radiological study in primates. Toronto: American Association of Neurological Surgeons, 1988;349.Google Scholar
  27. 27.
    Laurencin C, Domb A, Morris C, Brown V, Chasin M, McConnell R, et al. Poly(anhydride) administration in high doses in vivo: Studies of biocompatibility and toxicology. J Biomed Mat Res 1990;1463–81.Google Scholar
  28. 28.
    Tamargo RJ, Myseros JS, Epstein JI, Yang MB, Chasin M, Brem H. Interstitial chemotherapy of the 9L gliosarcoma: Controlled release polymers for drug delivery in the brain. Cancer Res 1993;53:329–33.PubMedGoogle Scholar
  29. 29.
    Brem H, Mahaley S, Vick NA, Black KL, Schold C, Burger PC, et al. Interstitial chemotherapy with drug polymer implants for the treatment of recurrent gliomas. J Neurosurg 1991;74:441–6.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media New York 1996

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  • Robert S. Langer

There are no affiliations available

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