Goodpasture Syndrome: Molecular Architecture and Function of Basement Membrane Antigen

  • Billy G. Hudson
  • Jörgen Wieslander
  • Billie J. WisdomJr.
  • Milton E. Noelken


In studies of victims from the influenza pandemic of 1918–1919, Ernest Goodpasture described the coexistence of fatal pulmonary hemorrhage and proliferative glomerulonephritis in a young man (25). The term Good- pasture syndrome was coined by Stanton and Tange in 1958 to describe cases characterized by the coexistence of these manifestations (73). The syndrome is now defined as an autoimmune disorder consisting of the triad of glomerulonephritis, lung hemorrhage, and antiglomerular basement membrane antibody formation, and it includes a broad spectrum of clinical features, ranging from massive pulmonary hemorrhage with little overt evidence of renal disease to fulminant crescentic glomerulonephritis and little overt evidence of pulmonary hemorrhage (24). Although the etiology of this syndrome remains unknown, profound advances have been made during the last 25 years in delineating the pathogenesis of the glomerulonephritis.


Influenza Polypeptide Quinone Galactose Triad 


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  1. 1.
    Abrahamson DR: Recent studies on the structure and pathology of basement membrane. J Pathol 149:257, 1986PubMedCrossRefGoogle Scholar
  2. 2.
    Abrahamson DR: Structure and development of the glomerular capillary wall and basement membrane. Am J Physiol 22:F783, 1987Google Scholar
  3. 3.
    Aumailley M, Timpl R: Attachment of cells to basement membrane collagen type IV. J Cell Biol 103:1569, 1986PubMedCrossRefGoogle Scholar
  4. 4.
    Bächinger HP, Fessier LI, Fessier JH: Mouse procollagen IV: Characterization and supramolecular association. J Biol Chem 257:9796, 1982PubMedGoogle Scholar
  5. 5.
    Bowman C, Lockwood CM: Clinical application of a radio-immunoassay for auto-antibodies to glomerular basement membrane. J Clin Lab Immunol 17:197, 1985PubMedGoogle Scholar
  6. 6.
    Brazel D, Pollner R, Oberbäumer I, Kühn K: Human basement membrane collagen (type IV): The amino acid sequence of the α2(IV) chain and its comparison with the α1(IV) chain reveals deletions in the α1(IV) chain. Eur J Biochem 172:35, 1988PubMedCrossRefGoogle Scholar
  7. 7.
    Brunner H, Schröder C, van Bennekom C, Lambermon E, Tuerlings J, Menzel D, Olbing H, Monnens L, Wieringa B, Ropers H-H: Localization of the gene for X-linked Alport’s syndrome. Kidney Int 34:507, 1988PubMedCrossRefGoogle Scholar
  8. 8.
    Buffaloe GW, Evans JE, McIntosh RM, Glassock RJ, Trade B, Tavel TB, Terman DS: Antibodies to human glomerular basement membrane: Modified methodology for detection in human serum. Clin Exp Immunol 39:136, 1980PubMedGoogle Scholar
  9. 9.
    Butkowski RJ, Langeveld JPM, Wieslander J, Hamilton J, Hudson BG: Localization of the Goodpasture epitope to a novel chain of basement membrane collagen. J Biol Chem 262:7874, 1987PubMedGoogle Scholar
  10. 10.
    Butkowski RJ, Wieslander J, Kleppel M, Michael AF, Fish AJ: Basement membrane collagen in the kidney: Regional localization of novel chains related to collagen IV. Kidney Int 35:1195, 1989PubMedCrossRefGoogle Scholar
  11. 11.
    Butkowski RJ, Wieslander J, Wisdom BJ, Barr JF, Noelken ME, Hudson BG: Properties of the globular domain of type IV collagen and its relationship to the Goodpasture antigen. J Biol Chem 260:3739, 1985PubMedGoogle Scholar
  12. 12.
    Bygren P, Freiburghaus C, Lindholm T, Simonsen O, Thysell H, Wieslander J: Goodpasture’s syndrome treatment with staphybcoccal protein A immunoadsorption. Lancet 11:1295, 1985CrossRefGoogle Scholar
  13. 13.
    Bygren P, Wieslander J, Heinegärd D: Glomerulonephritis induced in sheep by immunization with human glomerular basement membrane. Kidney Int 31:25, 1987PubMedCrossRefGoogle Scholar
  14. 14.
    Cederholm B, Wieslander J, Bygren P, Heingärd D: Circulating complexes containing IgA and fibronectin in patients with primary IgA nephropathy. Proc Natl Acad Sci USA 85:4865, 1988PubMedCrossRefGoogle Scholar
  15. 15.
    Couser WG: Rapidly progressive glomerulonephritis: Classification, pathogenetic mechanisms, and therapy. Am J Kidney Dis XI:449, 1988Google Scholar
  16. 16.
    Dean DC, Barr JF, Freytag JW, Hudson BG: Isolation of type IV procollagen-like polypeptides from glomerular basement membrane. J Biol Chem 258:590, 1983PubMedGoogle Scholar
  17. 17.
    Dennis J, Waller C, Timpl R, Schirrmacher V: Surface sialic acid reduces attachment of metastatic tumor cells to collagen IV and fibronectin. Nature 300:274, 1982PubMedCrossRefGoogle Scholar
  18. 18.
    Fessier LI, Fessier JH: Identification of the carboxyl peptides of mouse procollagen IV and its implications for the assembly and structure of basement membrane procollagen. J Biol Chem 257:9804, 1982Google Scholar
  19. 19.
    Fillit H, Damle SP, Gregory JD, Volin C, Poon-King T, Zabriskie J: Sera from patients with poststreptosococcal glomerulonephritis contain antibodies to glomerular heparan sulfate proteoglycan. J Exp Med 161:277, 1985PubMedCrossRefGoogle Scholar
  20. 20.
    Fish AJ, Kleppel M, Jeraj K, Michael AF: Enzyme immunoassay of anti-glomerular basement membrane antibodies. J Lab Clin Med 105:700, 1985PubMedGoogle Scholar
  21. 21.
    Fish AJ, Lockwood MC, Wong M, Price RG: Detection of Good-pasture antigen in fractions prepared from collagenase digests of human glomerular basement membrane. Clin Exp Immunol 55:58, 1984PubMedGoogle Scholar
  22. 22.
    Fouser LS, Michael AF, Kleppel MM, Vernier RL, Fish AJ: Nephritogenicity in sheep of the NC1 domain of type IV collagen from human glomerular basement membrane (hGBM) (abstr). Kidney Int 31:319, 1987Google Scholar
  23. 23.
    Glassock RJ: Clinical aspects of acute, rapidly progressive and chronic glomerulonephritis. In Diseases of the Kidney, Ed 3, edited by Early LE, Gottschalk CW, p 691–763. Boston, Little, Brown and Company, 1979Google Scholar
  24. 24.
    Glassock RJ, Cohen AH, Adler SG, Ward HJ: Secondary Glomerular Diseases. In The Kidney, Ed 3, edited by Brenner BM, Rector FC, pp 1014–1083. Philadelphia, WB Saunders, 1986Google Scholar
  25. 25.
    Goodpasture EW: The significance of certain pulmonary lesions in relation to the etiology of influenza. Am J Med Sci 158:863, 1919CrossRefGoogle Scholar
  26. 26.
    Grünfeld J-P: The clinical spectrum of hereditary nephritis. Kidney Int 27:83, 1985PubMedCrossRefGoogle Scholar
  27. 27.
    Hinglais N, Grünfeld J-P, Bois E: Characteristic ultrastructural lesion of the glomerular basement membrane in progressive hereditary nephritis (Alport’s syndrome). Lab Invest 27:473, 1972PubMedGoogle Scholar
  28. 28.
    Holdsworth SR, Golbus SM, Wilson CB: Characterization of collagenase solubilized human glomerular basement membrane antigens reacting with human antibodies (abstr). Kidney Int 16:797, 1979Google Scholar
  29. 29.
    Hunt JS, Macdonald PR, McGiven AR: Characterization of human glomerular basement membrane antigenic fractions isolated by affinity chromatography utilising anti-glomerular basement membrane autoantibodies. Biochem Biophys Res Commun 104:1025, 1982PubMedCrossRefGoogle Scholar
  30. 30.
    Jenis EH, Valeski JE, Calcagno PL: Variability of anti-GBM binding in hereditary nephritis. Clin Nephrol 15:111, 1981PubMedGoogle Scholar
  31. 31.
    Jeraj K, Kim Y, Vernier RL, Fish AJ, Michael AF: Absence of Goodpasture’s antigen in male patients with familial nephritis. Am J Kidney Dis 11:626, 1983Google Scholar
  32. 32.
    Johnson JP, Moore J, Austin HA III, Barlow JE, Antonovych TT, Wilson CB: Therapy of antiglomerular basement membrane antibody disease: Analysis of prognostic significance of clinical pathologic and treatment factors. Medicine 64:219, 1985PubMedGoogle Scholar
  33. 33.
    Johnson JP, Whitman W, Briggs WA, Wilson CB: Plasmapheresis and immunosuppressive agents in antibasement membrane antibody-induced Goodpasture’s syndrome. Am J Med 64:354, 1978PubMedCrossRefGoogle Scholar
  34. 34.
    Kashtan C, Fish AJ, Kleppel M, Yoshioka K, Michael AF: Nephritogenic antigen determinants in epidermal and renal basement membrane of kindreds with Alport-type familial nephritis. J Clin Invest 78:1035, 1986PubMedCrossRefGoogle Scholar
  35. 35.
    Kefalides NA, Ohno N, Wilson CB: Antigenic components of bovine lens capsule that cross-react serum from Goodpasture’s syndrome (abstr). Fed Proc 43:779, 1984Google Scholar
  36. 36.
    Kefalides NA, Pegg MT, Ohno N, Poon-King T, Zabriskie J, Fillit H: Antibodies to basement membrane collagen and to laminin are present in sera from patients with poststreptococcal glomerulonephritis. J Exp Med 163:588, 1986PubMedCrossRefGoogle Scholar
  37. 37.
    Kleppel MM, Kashtan CE, Butkowski RJ, Fish AJ, Michael AF: Alport familial nephritis: Absence of 28 kilodalton noncollagenous monomers of type IV collagen in glomerular basement membrane. J Clin Invest 80:263, 1987PubMedCrossRefGoogle Scholar
  38. 38.
    Kleppel MM, Michael AF, Fish AJ: Antibody specificity of human glomerular basement membrane type IV collagen NC1 subunits: Species variation in subunit composition. J Biol Chem 261:16547, 1986PubMedGoogle Scholar
  39. 39.
    Langeveld JPM, Wieslander J, Timoneda J, McKinney P, Butkowski RJ, Wisdom BJ, Hudson BG: Structural heterogeneity of the noncollagenous domain of basement membrane collagen. J Biol Chem 263:10481, 1988PubMedGoogle Scholar
  40. 40.
    Langeveld JPM, Yem AWT, Timoneda J, Saus J, Wisdom BJ, Jr, Hudson BG: Molecular structure of collagen IV of glomerular basement membrane. In Renal Basement Membranes in Health and Disease, edited by Price RG, Hudson BG, p 25–39. London, Academic, 1987Google Scholar
  41. 41.
    Lerner RA, Dixon FJ: Transfer of ovine experimental allergic glomerulonephritis (EAG) with serum. J Exp Med 124:431, 1966PubMedCrossRefGoogle Scholar
  42. 42.
    Lerner RA, Glassock RJ, Dixon FJ: The role of antiglomerular basement membrane antibody in the pathogenesis of human glomerulonephritis. J Exp Med 126:989, 1967PubMedCrossRefGoogle Scholar
  43. 43.
    Lockwood CM, Amos N, Peters DK: Goodpasture’s syndrome: Radioimmunoassay for measurement of circulating anti-GBM antibody (abstr). Kidney Int 16:93, 1979CrossRefGoogle Scholar
  44. 44.
    Lockwood CM, Boulton-Jones JM, Lowenthal RM, Simpson IJ, Peters DK, Wilson CB: Recovery from Goodpasture’s syndrome after immunosuppressive treatment and plasmapheresis. Br Med J 2:252, 1975PubMedCrossRefGoogle Scholar
  45. 45.
    Lockwood CM, Bowman C, Bakes D, Pressey A, Dash A: Autoimmunity and Glomerulonephritis. Adv Nephrol 16:291, 1987Google Scholar
  46. 46.
    Lockwood CM, Pussell B, Wilson CB, Peters DK: Plasma exchange in nephritis. Adv Nephrol 8:383, 1979Google Scholar
  47. 47.
    Mahieu P, Dardenne M, Bach JF: Detection of humoral and cell-mediated immunity to kidney basement membranes in human renal diseases. Am J Med 53:185, 1972PubMedCrossRefGoogle Scholar
  48. 48.
    Mahieu P, Lambert PH, Miescher PA: Detection of antiglomerular basement membrane antibodies by a radioimmunological technique. Clinical application in human nephropathies. J Clin Invest 54:128, 1974Google Scholar
  49. 49.
    Marquardt H, Wilson CB, Dixon FJ: Human glomerular basement membrane. Selective solubilization with chaotropes and chemical and immunologic characterization of its components. Biochemistry 12:3260, 1973Google Scholar
  50. 50.
    McCoy RC, Johnson HK, Stone WJ, Wilson CB: Absence of nephritogenic GBM antigen(s) in some patients with hereditary nephritis. Kidney Int 21:642, 1982PubMedCrossRefGoogle Scholar
  51. 51.
    McIntosh RM, Griswold W: Antigen identification in Goodpasture’s syndrome. Arch Pathol 92:329, 1971PubMedGoogle Scholar
  52. 52.
    McPhaul JJ, Dixon FJ: The presence of anti-gloraerular basement membrane antibodies in peripheral blood. J Immunol 103:1168, 1969PubMedGoogle Scholar
  53. 53.
    Milliner DS, Pierides AM, Holley KE: Renal transplantation in Alport’s syndrome: Anti-glomerular basement membrane glomerulonephritis in the allograft. Mayo Clin Proc 57:35, 1982PubMedGoogle Scholar
  54. 54.
    Olson DL, Anand SK, Landing BH, Heuser E, Grushkin CM, Lieberman E: Diagnosis of hereditary nephritis by failure of glomeruli to bind anti-glomerular basement membrane antibodies. J Pediatr 96:697, 1980PubMedCrossRefGoogle Scholar
  55. 55.
    Palotie A, Peltonen L, Risteli L, Risteli R: Effect of the structural components of basement membranes on the attachment of teratocarcinoma-derived endodermal cells. Exp Cell Res 144:31, 1983PubMedCrossRefGoogle Scholar
  56. 56.
    Palotie A, Tryggvason K, Peltonen L, Seppä H: Components of subendothelial aorta basement membrane: Immunohistochemical localization and role in cell attachment. Lab Invest 49:362, 1983PubMedGoogle Scholar
  57. 57.
    Papaioannou DF, Klassen J: An improved solid-phase immunoassay for anti-GBM antibodies. J Immunol Meth 53:195, 1982CrossRefGoogle Scholar
  58. 58.
    Peters DK, Rees AJ, Lockwood CM, Pusey CD: Treatment and prognosis in antibasement membrane antibody-mediated nephritis. Transplant Proc 14:513, 1982PubMedGoogle Scholar
  59. 59.
    Pusey CD, Dash A, Kershaw MJ, Morgan A, Reilly A, Rees AJ, Lockwood CM: A single autoantigen in Goodpasture’s syndrome identified by a monoclonal antibody to human glomerular basement membrane. Lab Invest 56:23, 1987PubMedGoogle Scholar
  60. 60.
    Rome L, Cuppage FF, Vertes V: Familial hematuric nephritis. Pediatrics 38:808, 1966PubMedGoogle Scholar
  61. 61.
    Rosenblatt SG, Knight W, Bannayan GA, Wilson CB, Stein JH: Treatment of Goodpasture’s syndrome with plasmapheresis. A case report and review of the literature. Am J Med 66:689, 1979Google Scholar
  62. 62.
    Rubin K, Hoo KM, Öbrink B, Timpl R: Substrate adhesion of rat hepatocytes: Mechanism of attachment to collagen substrates. Cell 24:463, 1981PubMedCrossRefGoogle Scholar
  63. 63.
    Rumpelt H-J: Hereditary nephropathy (Alport syndrome): Correlation of clinical data with glomerular basement membrane alterations. Clin Nephrol 13:203, 1980PubMedGoogle Scholar
  64. 64.
    Sariola H, Timpl R, von der Mark K, Mayne R, Fitch JM, Linsenmayer TF, Ekblom P: Dual origin of glomerular basement membrane. Dev Biol 101:86, 1984PubMedCrossRefGoogle Scholar
  65. 65.
    Saus J, Wieslander J, Langeveld JPM, Quinones S, Hudson BG: Identification of the Goodpasture antigen as the α3(IV) chain of collagen IV. J Biol Chem 263:13374, 1988PubMedGoogle Scholar
  66. 66.
    Savage COS, Pusey CD, Bowman C, Rees AJ, Lockwood CM: Antiglomerular basement membrane antibody mediated disease in the British Isles, 1980–4. Br Med J 292:301, 1986CrossRefGoogle Scholar
  67. 67.
    Savage COS, Pusey CD, Kershaw MJ, Cashman SJ, Harrison P, Hartley B, Turner DR, Cameron JS, Evans DJ, Lockwood CM: The Goodpasture antigen in Alport’s syndrome: Studies with a monoclonal antibody. Kidney Int 30:107, 1986PubMedCrossRefGoogle Scholar
  68. 68.
    Scheer RL, Grossman MA: Immune aspects of the glomerulonephritis associated with pulmonary hemorrhage. Ann Int Med 60:1009, 1964Google Scholar
  69. 69.
    Sisson S, Dysart NK, Fish AJ, Vernier RL: Localization of the Goodpasture antigen by immunoelectron microscopy. Clin Immunol Immunopathol 23:414, 1982PubMedCrossRefGoogle Scholar
  70. 70.
    Soininen R, Haka-Risku T, Prockop DJ, Tryggvason K: Complete primary structure of the α1-chain of human basement membrane (type IV) collagen. FEBS Lett 225:188, 1987PubMedCrossRefGoogle Scholar
  71. 71.
    Spear GS: Alport’s syndrome: A consideration of pathogenesis. Clin Nephrol 1:336, 1973PubMedGoogle Scholar
  72. 72.
    Spear GS, Slusser RJ: Alport’s syndrome: Emphasizing electron microscopic studies on the glomerulus. Am J Pathol 69:213, 1972PubMedGoogle Scholar
  73. 73.
    Stanton MC, Tange JD: Goodpasture’s syndrome (pulmonary haemorrhage associated with glomerulonephritis). Austr Ann Med 7:132, 1958Google Scholar
  74. 74.
    Steblay RW: Glomerulonephritis induced sheep by injections of heterologous glomerular basement membrane and Freund’s complete adjuvant. J Exp Med 116:253, 1962PubMedCrossRefGoogle Scholar
  75. 75.
    Steblay RW: Transfer of nephritis from sheep with autoimmune nephritis to recipient sheep by artery-to-artery cross circulation (abstr). Fed Proc 23:449, 1964Google Scholar
  76. 76.
    Timpl R: Recent advances in the biochemistry of glomerular basement membrane. Kidney Int 30:293, 1986PubMedCrossRefGoogle Scholar
  77. 77.
    Timpl R, Dziadek M: Structure, development and molecular pathology of basement membranes. Int Rev Exp Pathol 29:1, 1986PubMedGoogle Scholar
  78. 78.
    Timpl R, Wiedemann H, Van Delden V, Furthmayr H, Kühn K: A network model for the organization of type IV collagen molecules in basement membranes. Eur J Biochem 120:203, 1981PubMedCrossRefGoogle Scholar
  79. 79.
    Towbin H, Rosenfelder G, Wieslander J, Avila JL, Rojas M, Szarfman A, Esser K, Nowack H, Timpl R: Circulating antibodies to mouse laminin in Chagas disease, American cutaneous leishmaniasis, and normal individuals recognize terminal galactosyl(α1–3)-galactose epitopes. J Exp Med 166:419, 1987PubMedCrossRefGoogle Scholar
  80. 80.
    von der Mark H, Oberbäumer I, Timpl R, Kemler R, Wick G: Immunochemical and autoantigenic properties of the globular domain of basement membrane collagen (type IV). Eur J Biochem 146:555, 1985PubMedCrossRefGoogle Scholar
  81. 81.
    Walker RG, Scheinkestel C, Becker GJ, Owen JE, Dowling JP, Kincaid-Smith P: Clinical and morphological aspects of the management of crescentic anti-glomerular basement membrane antibody (anti-GBM) nephritis/Goodpasture’s syndrome. Q J Med 54:75, 1985PubMedGoogle Scholar
  82. 82.
    Weber M, Sorger K-H, zum Büschenfelde M, Köhler H: A Good-pasture-like syndrome in rabbits induced by the dissociated human NC1 molecule (abstr). Kidney Int, in pressGoogle Scholar
  83. 83.
    Wheeler J, Sussman M: Enzyme-linked immunosorbent assay for circulating anti-glomerular antibodies. Clin Exp Immunol 45:271, 1981PubMedGoogle Scholar
  84. 84.
    Wick G, VonVon der Mark H, Dietrich H, Timpl R: Globular domain of basement membrane collagen induces autoimmune pulmonary lesions in mice resembling human Goodpasture disease. Lab Invest 55:308, 1986PubMedGoogle Scholar
  85. 85.
    Wieslander J, Barr JF, Butkowski RJ, Edwards SJ, Bygren P, Heinegård D, Hudson BG: Autoimmune disease of basement membranes: Localization of Goodpasture’s antigen to type IV collagen (abstr). Fed Proc 43:1005, 1984Google Scholar
  86. 86.
    Wieslander J, Barr JF, Butkowski RJ, Edwards SJ, Bygren P, Heinegård D, Hudson BG: Goodpasture antigen of the glomerular basement membrane: Localization to noncollagenous regions of type IV collagen. Proc Natl Acad Sci USA 81:3838, 1984PubMedCrossRefGoogle Scholar
  87. 87.
    Wieslander J, Bygren P, Heinegård D: Antiglomerular basement membrane antibody: Antibody specificity in different forms of glomerulonephritis. Kidney Int 23:855, 1983PubMedCrossRefGoogle Scholar
  88. 88.
    Wieslander J, Bygren P, Heinegård D: Isolation of the specific glomerular basement membrane antigen involved in Goodpasture syndrome. Proc Natl Acad Sci USA 81:1544, 1984PubMedCrossRefGoogle Scholar
  89. 89.
    Wieslander J, Bygren PG, Heinegård D: Anti-basement membrane antibody: Immunoenzymatic assay and specificity of antibodies. Scand J Clin Lab Invest 41:763, 1981CrossRefGoogle Scholar
  90. 90.
    Wieslander J, Heinegård D: The involvement of type IV collagen in Goodpasture syndrome. Ann NY Acad Sci 460:363, 1985PubMedCrossRefGoogle Scholar
  91. 91.
    Wieslander J, Kataja M, Hudson BG: Characterization of the human Goodpasture antigen. Clin Exp Immunol 69:332, 1987PubMedGoogle Scholar
  92. 92.
    Wieslander J, Langeveld J, Butkowski R, Jodlowski M, Noelken M, Hudson BG: Physical and immunochemical studies of the globular domain of type IV collagen: Cryptic properties of the Goodpasture antigen. J Biol Chem 260:8564, 1985PubMedGoogle Scholar
  93. 93.
    Wilson CB: Radioimmunoassay for anti-glomerular basement membrane antibodies. In Manual for Clinical Immunology, edited by Rose NR, Friedman H, p 376. Washington, American Society for Microbiology, 1980Google Scholar
  94. 94.
    Wilson CB, Dixon FJ: Anti-glomerular basement membrane antibody-induced glomerulonephritis. Kidney Int 3:74, 1973PubMedCrossRefGoogle Scholar
  95. 95.
    Wilson CB, Holdsworth SR, Neale TJ: Anti-basement membrane antibodies in immunologic renal disease. Aust New Zealand J Med 11:94, 1981CrossRefGoogle Scholar
  96. 96.
    Wilson CB, Marquardt H, Dixon FJ: Radioimmunoassay (RIA) for circulating antiglomerular basement (GBM) antibodies (abstr). Kidney Int 6:114a, 1974Google Scholar
  97. 97.
    Yoshikawa N, Cameron AH, White RHR: The glomerular basal lamina in hereditary nephritis. J Pathol 135:199, 1981PubMedCrossRefGoogle Scholar
  98. 98.
    Yoshioka K, Kleppel M, Fish AJ: Analysis of nephritogenic antigens in human glomerular basement membrane by two-dimensional gel electrophoresis. J Immunol 134:3831, 1985PubMedGoogle Scholar
  99. 99.
    Yurchenco PD, Ruben GC: Basement membrane structure in situ: Evidence for lateral associations in the type IV collagen network. J Cell Biol 105:2559, 1987PubMedCrossRefGoogle Scholar
  100. 100.
    Yurchenco PD, Tsilibary EC, Charonis AS, Furthmayr H: Models for the self-assembly of basement membrane. J Histochem Cytochem 34:93, 1986PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Billy G. Hudson
    • 1
    • 2
  • Jörgen Wieslander
    • 1
    • 2
  • Billie J. WisdomJr.
    • 1
    • 2
  • Milton E. Noelken
    • 1
    • 2
  1. 1.Department of Biochemistry and Molecular BiologyUniversity of Kansas Medical CenterKansas CityUSA
  2. 2.Department of NephrologyUniversity of LundLundSweden

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