Drug Discovery pp 365-376 | Cite as

Cimetidine

  • Robert A. Maxwell
  • Shohreh B. Eckhardt

Abstract

Peptic ulcers are circumscribed lesions of the alimentary mucosa that penetrate through to its muscular layer. They occur most commonly in the proximal duodenum and also in the lesser curvature of the stomach. These ulcers are always associated with acid and pepsin secretion, and seem to result from a disturbance in the balance between the ulcerogenic potential of such secretions and the protective effects of mucus production, membrane barriers to the acid and pepsin, and the regeneration of mucosal cells (Stedman, 1982; Shearman and Finlayson, 1982; Berkow, 1982; Lampe, 1986). Venables et al. (1978) noted that 10% of the population is said to suffer peptic ulceration at some time in their lives.

Keywords

Placebo Neutropenia Catecholamine Propranolol Constipation 

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Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Robert A. Maxwell
    • 1
  • Shohreh B. Eckhardt
    • 2
  1. 1.The Wellcome Research Laboratories ResearchTriangle ParkUSA
  2. 2.University of Vermont College of MedicineBurlingtonUSA

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