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Purification of β,γ Subunits of Guanine Nucleotide Binding Proteins

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Receptor Purification

Part of the book series: Receptor Purification ((RP,volume 1))

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Abstract

Guanine nucleotide binding proteins (G proteins) are now known to constitute a family of regulatory or transducer molecules that link external membrane-bound receptors to corresponding intracellular effector signals in a wide variety of cell types. These established/putative effector systems are summarized in Table 1 for G proteins that have been purified to homogeneity and whose functions have been directly tested to date. It is important to realize that the fact that a particular purified G protein can be shown to stimulate a given effector in a reconstitution system does not prove this to be the function normally served by that G protein in situ.

Table 1 Functions of Purified G Proteins

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Cooney, D., Keenan, A.K. (1990). Purification of β,γ Subunits of Guanine Nucleotide Binding Proteins. In: Litwack, G. (eds) Receptor Purification. Receptor Purification, vol 1. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0461-9_4

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  • DOI: https://doi.org/10.1007/978-1-4612-0461-9_4

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6771-3

  • Online ISBN: 978-1-4612-0461-9

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