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Purification and Cloning of Central Serotonin Receptors

  • Henri Gozlan
  • Salah El Mestikawy
  • Michel Hamon
Part of the Receptor Purification book series (RP, volume 1)

Abstract

Serotonin (5-hydroxytryptamine, 5-HT) is a neurotransmitter involved in the control of various physiological functions and brain disorders, and its effects are mediated through several classes of specific 5-HT receptors (Osborne and Hamon, 1988). Indeed the demonstration of the heterogeneity of 5-HT receptors was reported as far back as 1957 (Gaddum and Picarelli, 1957), and became more evident during the past five years. To date, the development of radioligand binding techniques has established that 5-HT receptors are divided into three main classes, designated 5-HT1, 5-HT2 and 5-HT3, with different pharmacological properties, regional distributions, and functions in the central nervous system (CNS) (Bradley et al., 1986; Tricklebank, 1985).

Keywords

Soluble Fraction Bovine Brain Binding Subunit Photoaffinity Label Solubilized Site 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. Allgren, R. L., Kyncl, M. M. A., and Ciaranello, R. D. (1985) Brain Res. 348, 77–85.PubMedCrossRefGoogle Scholar
  2. Asarch, K. B. and Shih, J. C. (1987) J. Neurochem. 48,1494–1501.PubMedCrossRefGoogle Scholar
  3. Bouhelal, R., Smounya, L., and Bockaert, J. (1988) Eur. J. Pharmacol. 151,189–196.PubMedCrossRefGoogle Scholar
  4. Bradley, P. B., Engel, G., Feniuk, W., Fozard, J. R., Humphrey, P. P. A., Middlemiss, D. N., Mylecharane, E. J., Richardson, B. P., and Saxena, P. R. (1986) Neuro-pharmacology 25, 563–576.Google Scholar
  5. Brann, M. R. (1985) Biochem. Biophys. Res. Commun. 133, 1181–1186.PubMedCrossRefGoogle Scholar
  6. Bruns, R. F., Lawson-Wendling, K., and Pugsley, T. A. (1983) Anal. Biochem. 132, 74–81.PubMedCrossRefGoogle Scholar
  7. Chan, B. and Madras, B. K. (1982) Eur. J. Pharmacol. 83,1–10.PubMedCrossRefGoogle Scholar
  8. Cheng, S. H. and Shih, J. C. (1979) Life Sci. 25, 2197–2203.PubMedCrossRefGoogle Scholar
  9. Conn, P. J. and Sanders-Bush, E. (1985) J. Pharmacol. Exp. Ther. 234,195–203.PubMedGoogle Scholar
  10. Conn, P. J., Sanders-Bush, E., Hoffman, B. J., and Hartig, P. R. (1986) Proc. Natl. Acad. Sci. USA 83, 4086–4088.PubMedCrossRefGoogle Scholar
  11. Cotecchia, S., Schwinn, D. A., Randall, R. R., Lefkowitz, R., Caron, M. G., and Kobilka, B. K. (1988) Proc. Natl. Acad. Sci. USA 85, 7159–7163.PubMedCrossRefGoogle Scholar
  12. Devivo, M. and Maayani, S. (1986) J. Pharmacol. Exp. Ther. 238, 248–253.Google Scholar
  13. Dourish, C. T., Ahlenius, S., and Hutson, P. H. (1987) “Brain 5-HT IA Receptors, Ellis Horwood, Chichester, p. 306.Google Scholar
  14. El Mestikawy, S., Cognard, C., Gozlan, H., and Hamon, M. (1988) J. Neurochem. 51, 1031–1040.PubMedCrossRefGoogle Scholar
  15. El Mestikawy, S., Taussig, D., Gozlan, H., Emerit, M. B., Ponchant, M., and Hamon, M. (1989) J. Neurochem. 53,1555–1566.PubMedCrossRefGoogle Scholar
  16. Emerit, M. B., Gozlan, H., Marquet, A., and Hamon, M. (1986) Eur. J. Pharmacol. 127, 67–81.PubMedCrossRefGoogle Scholar
  17. Emerit, M. B., El Mestikawy, S., Gozlan, H., Cossery, J. M., Besselievre, R., Marquet, A., and Hamon, M. (1987) J. Neurochem. 49,373–380.PubMedCrossRefGoogle Scholar
  18. Fargin, A., Raymond, J. R., Lohse, M. J., Kobilka, B. K., Caron, M. G., and Lefkowitz, R. J. (1988) Nature 335, 358–360.PubMedCrossRefGoogle Scholar
  19. Ferry, D. R., Goll, A., Glossmann, H., Glaser, T., and Traber, T. (1988) Neurosci. Res. Commun. 2,9–17.Google Scholar
  20. Gaddum, J. H. and Picarelli, Z. P. (1957) Brit. J. Pharmacol. Chemother. 12, 323–328.CrossRefGoogle Scholar
  21. Gallaher, T. K. and Wang, H. H. (1988) Proc. Natl. Acad. Sci. USA 85,2378–2382.PubMedCrossRefGoogle Scholar
  22. Glossman, H. and Neville, D. M. (1971) J. Biol. Chem. 246, 6339–6346.Google Scholar
  23. Gozlan, H., El Mestikawy, S., Pichat, L., Glowinski, J., and Hamon, M. (1983) Nature 305, 140–142.PubMedCrossRefGoogle Scholar
  24. Gozlan, H., Emerit, M. B., Hall, M. D., Nielsen, M., and Hamon, M. (1986) Biochem. Pharmacol. 35,1891–1897.PubMedCrossRefGoogle Scholar
  25. Gozlan, H., Emerit, M. B., El Mestikawy, S., Cossery, J. M., Marquet, A., Besselievre, R., and Hamon, M. (1987) J. Recept. Res. 7,195–221.PubMedGoogle Scholar
  26. Hall, M. D., Gozlan, H., Emerit, M. B., El Mestikawy, S., Pichat, L., and Hamon, M. (1986) Neurochem. Res. 11, 891–912.PubMedCrossRefGoogle Scholar
  27. Hamblin, M. W., Ariani, K., Adriaenssens, P. I., and Ciaranello, R. D. (1987) J. Pharmacol. Exp. Ther. 243, 989–1001.PubMedGoogle Scholar
  28. Hamon, M., Fattaccini, C. M., Adrien, J., Gallissot, M.-C., Martin, P., and Gozlan, H. (1988) J. Pharmacol. Exp. Ther. 246, 745–752.PubMedGoogle Scholar
  29. Hamon, M. (1987) in “Pharmacology” (Rand, M. J. and Raper, C., eds.), Elsevier, Amsterdam, pp. 281–284.Google Scholar
  30. Hamon, M., Emerit, M. B., El Mestikawy, S., Vergé, D., Daval, G., Marquet, A., and Gozlan, H. (1987) in “Brain 5-HT IA Receptors“ (Dourish, C. T., Alhenius, S., and Hutson, P. H., eds.),Horwood, Chichester, pp. 34–51.Google Scholar
  31. Heuring, R. E. and Peroutka, S. J. (1987) J. Neurosci. 7, 894–903.PubMedGoogle Scholar
  32. Hoyer, D., Engel, G., and Kalkman, H. O. (1985) Eur. J. Pharmacol. 118 13–23.PubMedCrossRefGoogle Scholar
  33. Hoyer, D. and Neijt, H. C. (1987) Eur. J. Pharmacol. 143, 291–292.PubMedCrossRefGoogle Scholar
  34. Hoyer, D. and Schoeffter, P. (1988) Eur. J. Pharmacol. 147,145–147.PubMedCrossRefGoogle Scholar
  35. Ilien, B., Gorissen, H., and Laduron, P. M. (1982) Mol. Pharmacol. 22, 243–249.PubMedGoogle Scholar
  36. Ilien, B., Schotte, A., and Laduron, P. M. (1982a) FEBS Lett. 138 311–315.CrossRefGoogle Scholar
  37. Julius, D., MacDermott, A. B., Axel, R., and Jessell, T. M. (1988) Science 241 558–564.PubMedCrossRefGoogle Scholar
  38. Kendall, D. A. and Nahorski, S. R. (1985) J. Pharmacol. Exp. Ther. 233, 473–479.PubMedGoogle Scholar
  39. Kilpatrick, G. J., Jones, B. J., and Tyers, M. B. (1987) Nature 330, 746–748.PubMedCrossRefGoogle Scholar
  40. Kobilka, B. K., Frielle, T., Collins, S., Yang-Feng, T. L., Kobilka, T. S., Francke, U., Lefkowitz, R. J., and Caron, M. G. (1987) Nature 329, 75–79.PubMedCrossRefGoogle Scholar
  41. Kobilka, B. K., Matsui, H., Kobilka, T. S., Yang-Feng, T. L., Francke, U., Caron, M. G., Lefkowitz, R. J., and Regan, J. W. (1987a) Science 238, 650–656.CrossRefGoogle Scholar
  42. Kobilka, B. K., Kobilka, T. S., Daniel, K., Regan, J. W., Caron, M. G., and Lefkowitz, R. J. (1988) Science 240 1310–1316.PubMedCrossRefGoogle Scholar
  43. Leysen, J. E., Niemegeers, C. J. E., Van Nueten, J. M., and Laduron, P. M. (1982) 3H-Ketanserin (R 41468) Mol. Pharmacol. 21 301–314.PubMedGoogle Scholar
  44. Lowe, M. E. and Kempner, E. S. (1982) J. Biol. Chem. 257,12478–12480.PubMedGoogle Scholar
  45. Lübbert, H., Hoffman, B. J., Snutch, T. P., Van Dyke, T., Levine, A. J., Hartig, P. R., Lester, H. A., and Davidson, N. (1987) Proc. Natl. Acad. Sci. USA 84,4332–4336.PubMedCrossRefGoogle Scholar
  46. Lübbert, H., Snutch, T. P., Lester, H. A., and Davidson, N. (1987) J. Neuroscience 7, 1159–1165.Google Scholar
  47. Nielsen, M. and Braestrup, C. (1988) J. Biol. Chem. 263,11900–11906.PubMedGoogle Scholar
  48. Nishino, N. and Tanaka, C. (1985) Life Sci. 37,1167–1174.PubMedCrossRefGoogle Scholar
  49. Osborne, N. N. and Hamon, M. (1988) “Neuronal Serotonin.” J. Wiley and Sons, Chichester, Amsterdam, p. 555.Google Scholar
  50. Pazos, A. and Palacios, J. M. (1985) Brain Res. 346, 205–230.PubMedCrossRefGoogle Scholar
  51. Pazos, A., Hoyer, D., and Palacios, J. M. (1985) Eur. J. Pharmacol. 106 539–546.CrossRefGoogle Scholar
  52. Pazos, A., Cortes, R., and Palacios, J. M. (1985a) Brain Res. 346, 231–249.CrossRefGoogle Scholar
  53. Pedigo, N. W., Yamamura, H. I., and Nelson, D. L. (1981) J. Neurochem. 36,220–226.PubMedCrossRefGoogle Scholar
  54. Pritchett, D. B., Bach, A. W. J., Wozny, M., Taleb, O., Dal Toso, R., Shih, J. C., and Seeburg, P. H. (1988) EMBO J., 7,4135–4140.PubMedGoogle Scholar
  55. Ransom, R. W., Asarch, K. B., and Shih, J. C. (1985) J. Neurochem. 46,68–75.CrossRefGoogle Scholar
  56. Ransom, R. W., Asarch, K. B., and Shih, J. C. (1986) J. Neurochem. 47,1066–1072.PubMedCrossRefGoogle Scholar
  57. Regan, J. W., Kobilka, T. S., Yang-Feng, T. L., Caron, M. G., Lefkowitz, R. J., and Kobilka, B. K. (1988) Proc. Natl. Acad. Sci. USA 85 6301–6305.PubMedCrossRefGoogle Scholar
  58. Richardson, B. P. and Engel, G. (1986) TINS 424–428.Google Scholar
  59. Rousselle, J. C., Gillet, G., and Fillon, G. (1985) J. Pharmacol. (Paris) 16 421–438.Google Scholar
  60. Saitoh, T. and Shih, J. C. (1987) J. Neurochem. 491361–1366.PubMedCrossRefGoogle Scholar
  61. Takeuchi, Y., Yang, W., and Shih, J. C. (1988) J. Neurochem. 511343–1349.PubMedCrossRefGoogle Scholar
  62. Tricklebank, M. D. (1985) Trends Pharmacol. Sci. 6 403–407.CrossRefGoogle Scholar
  63. Vandenberg, S. R., Allgren, R. L., Todd, R. D., and Ciaranello, R. D. (1983) Proc. Natl. Acad. Sci. USA 80 3508–3512.PubMedCrossRefGoogle Scholar
  64. Vergé, D., Daval, G., Marcinkiewicz, M., Patey, A., El Mestikawy, S., Gozlan, H., and Hamon, M. (1986) J. Neurosci. 6 3474–3482.PubMedGoogle Scholar
  65. Wouters, W., Van Dun, J., Leysen, J. E., and Laduron, P. M. (1985) Eur. J. Pharmacol. 115 1–9.PubMedCrossRefGoogle Scholar
  66. Wouters, W., Van Dun, J., Leysen, J. E., and Laduron, P. M. (1987) FEBS Lett. 213 359–364.PubMedCrossRefGoogle Scholar
  67. Yagaloff, K. E. and Hartig, P. R. (1986) Mol. Pharrnacol. 29,120–125.Google Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Henri Gozlan
  • Salah El Mestikawy
  • Michel Hamon

There are no affiliations available

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