Advertisement

Platelet-Derived Growth Factor B Type Receptor

  • Carl-Henrik Heldin
  • Lars Rönnstrand
Part of the Receptor Purification book series (RP, volume 1)

Abstract

Platelet-derived growth factor (PDGF) is a major mitogen in serum for connective tissue cells (for reviews, see Heldin et al., 1985; Ross et al., 1986). The in vivo function of PDGF is not known. However, the fact that PDGF is released from platelets in conjunction with the blood coagulation and stimulates not only proliferation, but also chemotaxis and synthesis of matrix proteins of connective tissue cells, is compatible with a function for PDGF in wound healing (Heldin et a1.,1985; Ross et al., 1986). The fact that PDGF is expressed in the placenta also suggests a role for PDGF during the development (Goustin et al., 1985). In addition, PDGF has been found to be produced by type-1 astrocytes and to act on O-2A progenitor cells that differentiate to oligodendrocytes and type-2 astrocytes, suggesting a role for PDGF in the developing rat brain (Richardson et al., 1988; Noble et al., 1988). PDGF may also have adverse effects in several conditions involving cell proliferation, such as atherosclerosis, various fibrotic conditions, as well as malignant diseases (Heldin et al., 1985; Ross et al., 1986). The latter possibility is illustrated by the fact that PDGF is homologous to p28sis, the transforming protein of simian sarcoma virus (Waterfield et al., 1983; Doolittle et al., 1983).

Keywords

Receptor Kinase Tyrosine Kinase Domain Connective Tissue Cell PDGF Receptor Dialysis Buffer 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Betsholtz, C., Johnsson, A., Heldin, C.-H., Westermark, B., Lind, P., Urdea, M. S., Eddy, R., Shows, T. B., Philpott, K., Mellor, A., Knott, T. J., and Scott, J. (1986) Nature 320, 695–699.PubMedCrossRefGoogle Scholar
  2. Bishayee, S., Ross, A. H., Womer, R., and Scher, C. D. (1986) Proc. Natl. Acad. Sci. USA 83, 6756–6760.PubMedCrossRefGoogle Scholar
  3. Claesson-Welsh, L., Rönnstrand, L., and Heldin, C.-H. (1987) Proc. Natl. Acad. Sci. USA 84, 8796–8800.PubMedCrossRefGoogle Scholar
  4. Claesson-Welsh, L., Eriksson, A., Morén, A., Severinsson, L., Ek, B., Östman, A., Betsholtz, C., and Heldin, C.-H. (1988) Mol. Cell. Biol. 8, 3476–3486.PubMedGoogle Scholar
  5. Claesson-Welsh, L., Hammacher, A., Westermark, B., Heldin, C.-H., and Nistér, M. (1989) J. Biol. Chem. 264,1742–1747.PubMedGoogle Scholar
  6. Cooper, J. A., Bowen-Pope, D. F., Raines, E., Ross, R., and Hunter, T. (1982) Cell 31, 263–273.PubMedCrossRefGoogle Scholar
  7. Coussens, L., van Beveren, C., Smith, D., Chen, E., Mitchell, R. L., Isacke, C. M., Verma, I., and Ullrich, A. (1986) Nature 320, 277–280.PubMedCrossRefGoogle Scholar
  8. Daniel, T. O., Tremble, P. M., Frackelton, A. R., Jr., and Williams, L. T. (1985) Proc. Natl. Acad. Sci. USA 82,2684–2687.PubMedCrossRefGoogle Scholar
  9. Doolittle, T. F., Hunkapiller, M. W., Hood, L. E., Devare, S. G., Robbins, K. C., Aaronson, S. A., and Antoniades, H. N. (1983) Science 221, 275–277.PubMedCrossRefGoogle Scholar
  10. Ek, B., Westermark, B., Wasteson, A., and Heldin, C.-H. (1982) Nature 295, 419, 420. Ek, B. and Heldin, C.-H. (1984) J. Biol. Chem. 259,11145–11152.Google Scholar
  11. Ek, B. and Heldin, C.-H. (1986) Eur. J. Biochem. 155, 409–413.PubMedCrossRefGoogle Scholar
  12. Escobedo, J. A., Keating, M. T., Ives, H. E., and Williams, L. T. (1988) J. Biol. Chem. 263, 1482–1487.PubMedGoogle Scholar
  13. Frackelton, A. R., Jr., Tremble, P. M., and Williams, L. T. (1984) J. Biol. Chem. 259,7909–7915.PubMedGoogle Scholar
  14. Goustin, A. S., Betsholtz, C., Pfeiffer-Ohlsson, S., Persson, H., Rydnert, J., Bywater, M., Holmgren, G., Heldin, C.-H., Westermark, B., and Ohlsson, R. (1985) Cell 41, 301–312.PubMedCrossRefGoogle Scholar
  15. Gronwald, R. G. K., Grant, F. J., Haldeman, B. A., Hart, C. E., O’Hara, P. J., Hagen, F. S., Ross, R., Bowen-Pope, D. F., and Murray, M. J. (1988) Proc. Natl. Acad. Sci. USA 85, 3435–3439.PubMedCrossRefGoogle Scholar
  16. Hammacher, A., Hellman, U., Johnsson, A., Gunnarsson, K., Östman, A., Westermark, B., Wasteson, A., and Heldin, C.-H. (1988) J. Biol. Chem. 263, 16493–16498.PubMedGoogle Scholar
  17. Hart, C. E., Seifert, R. A., Ross, R., and Bowen-Pope, D. F. (1987) J. Biol. Chem. 262, 10780–10785.PubMedGoogle Scholar
  18. Hart, C. E., Forstrom, J. W., Kelly, J. D., Seifert, R. A., Smith, R. A., Ross, R., Murray, M., and Bowen-Pope, D. F. (1988) Science 240,1529–1531.PubMedCrossRefGoogle Scholar
  19. Heldin, C. -H., Wasteson, A., and Westermark, B. (1985) Mol. Cell. Endocrinol. 39,169–187.PubMedCrossRefGoogle Scholar
  20. Heldin, C. -H., Johnsson, A., Wennergren, S., Wernstedt, C., Betsholtz, C., and Westermark, B. (1986) Nature 319, 511–514.PubMedCrossRefGoogle Scholar
  21. Heldin, C.-H., Bäckström, G., Östman, A., Hammacher, A., Rönnstrand, L., Rubin, K., Nistér, M., and Westermark, B. (1988) EMBO J. 7,1387–1394.PubMedGoogle Scholar
  22. Heldin, C.-H., Ernlund, A., Rorsman, C., and Rönnstrand, L. (1989) J. Biol. Chem. 264, 8905–8912.PubMedGoogle Scholar
  23. Johnsson, A., Heldin, C.-H., Westermark, B., and Wasteson, A. (1982) Biochem. Biophys. Res. Comm. 104, 66–74.PubMedCrossRefGoogle Scholar
  24. Josephs, S. F., Guo, C., Ratner, L., and Wong-Staal, F. (1984) Science 223,487–491.PubMedCrossRefGoogle Scholar
  25. Keating, M. T. and Williams, L. T. (1987) J. Biol. Chem. 262, 7932–7937.PubMedGoogle Scholar
  26. Nishimura, J., Huang, J. S., and Deuel, T. F. (1982) Proc. Natl. Acad. Sci. USA 79,4303–4307.PubMedCrossRefGoogle Scholar
  27. Nistér, M., Hammacher, A., Mellström, K., Siegbahn, A., Rönnstrand, L., Westermark, B., and Heldin, C.-H. (1988a) Cell 52, 791–799.CrossRefGoogle Scholar
  28. Noble, M., Murray, K., Stroobant, P., Waterfield, M., and Riddle, P. (1988) Nature 333, 560–562.PubMedCrossRefGoogle Scholar
  29. Östman, A., Bäckström, G., Fong, N., Betsholtz, C., Wernstedt, C., Hellman, U., Westermark, B., Valenzuela, P., and Heldin, C.-H. (1989) Growth Factors 1, 271–281.PubMedCrossRefGoogle Scholar
  30. Petruzzelli, L., Herrera, R., and Rosen, O. M. (1984) Proc. Natl. Acad. Sci. USA 82, 3327–3331.CrossRefGoogle Scholar
  31. Richardson, W. D., Pringle, N., Mosley, M. J., Westermark, B., and Dubois-Dalcq, M. (1988) Cell 53, 309–319.PubMedCrossRefGoogle Scholar
  32. Rönnstrand, L., Beckmann, M. P., Faulders, B., Östman, A., Ek, B., and Heldin, C.-H. (1987) J. Biol. Chem. 262, 2929–2932.PubMedGoogle Scholar
  33. Rönnstrand, L., Terracio, L., Claesson-Welsh, L., Heldin, C.-H., and Rubin, K. (1988) J. Biol. Chem. 263,10429–10435.PubMedGoogle Scholar
  34. Ross, R., Raines, E. W., and Bowen-Pope, D. F. (1986) Cell 46,155–169.PubMedCrossRefGoogle Scholar
  35. Rubin, K., Terrado, L., Rönnstrand, L., Heldin, C.-H., and Klareskog, L. (1988a) Scand. J. Immunol. 27, 285–294.CrossRefGoogle Scholar
  36. Rubin, K., Tingström, A., Hansson, G. K., Larsson, E., Rönnstrand, L., Klareskog, L., Claesson-Welsh, L., Heldin, C.-H., Fellström, B., and Terrado, L. (1988b) Lancet 1, 1353–1356.CrossRefGoogle Scholar
  37. Severinsson, L., Claesson-Welsh, L., and Heldin, C.-H. (1989) Eur. J. Biochem. 182, 679–686.PubMedCrossRefGoogle Scholar
  38. Stroobant, P. and Waterfield, M. D. (1984) EMBO J. 3, 2963–2967.PubMedGoogle Scholar
  39. Terracio, L., Rönnstrand, L., Tingström, A., Rubin, K., Claesson-Welsh, L., Funa, K., and Heldin, C.-H. (1988) J. Cell Biol. 107, 1947–1957.PubMedCrossRefGoogle Scholar
  40. Waterfield, M. D., Scrace, T., Whittle, N., Stroobant, P., Johnsson, A., Wasteson, A., Westermark, B., Heldin, C.-H., Huang, J. S., and Deuel, T. F. (1983) Nature 304, 35–39.PubMedCrossRefGoogle Scholar
  41. Yarden, Y., Escobedo, J. A., Kuang, W.-J., Yang-Feng, T. L., Daniel, T. O., Tremble, P. M., Chen, E. Y., Ando, M. E., Harkins, R. N., Francke, U., Fried, V. A., Ullrich, A., and Williams, L. T. (1986) Nature 323, 226–232.PubMedCrossRefGoogle Scholar
  42. Yarden, Y., Kuang, W.- J., Yang-Feng, T., Coussens, L., Munemitsu, S., Dull, T. J., Chen, E., Schlessinger, J., Francke, U., and Ullrich, A. (1987) EMBO J. 6, 3341–3351.PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media New York 1990

Authors and Affiliations

  • Carl-Henrik Heldin
  • Lars Rönnstrand

There are no affiliations available

Personalised recommendations