Skip to main content
SpringerLink
Log in

Fatty Acid Ethyl Esters, Alcohol, and Liver Changes

  • Chapter
Liver Pathology and Alcohol

Part of the book series: Drug and Alcohol Abuse Reviews ((DAAR,volume 2))

Abstract

More than 25 years ago the World Health Organization concluded that an important association existed between excessive drinking of alcohol and development of tumors of the pharynx, esophagus, stomach, and liver. 1There are at least 10 million alcoholics in the US, costing the economy over $100 billion annually, 2but no generally accepted mechanism has been proposed that accounts for the propensity of certain individuals to drink to excess or to develop alcohol-related damage to organs.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 89.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 119.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. World Health Organization (1964) Association between drinking and carcinogenesis. World Health Bulletin 9, 16,17.

    Google Scholar 

  2. L. J. West (1984) Alcoholism. Ann. Intern. Med. 100, 405–416.

    CAS  Google Scholar 

  3. C. S. Lieber and L. M. DeCarli (1968) Ethanol oxidation by hepatic microsomes: Adaptive increase after ethanol feeding. Science 162, 917,918.

    Google Scholar 

  4. A. Lochner, R. Cowley, and A. Brink (1969) Effect of ethanol on metabolism and junction of perfused rat heart. Am. Heart J. 78, 770–780.

    Article  PubMed  CAS  Google Scholar 

  5. H. H. Raskin and L. Sokoloff (1972) Enzyme catalysing ethanol metabolism in neutral and somatic tissue of the rat. J. Neurochem. 19, 273–282.

    Article  PubMed  CAS  Google Scholar 

  6. L. M. Lefkowitch and J. Fenoglio (1983) Liver disease in alcoholic cardiomyopathy: Evidence against cirrhosis. Hum. Pathol.14, 457–463.

    CAS  Google Scholar 

  7. C. J. Ericksson and H. W. Sippel (1977) The distribution and metabolism of acetaldehyde in rats during ethanol oxidation-I. The distribution of acetaldehyde in liver, brain, blood and breath. Biochem. PharmacoL 26, 241–247.

    Google Scholar 

  8. E. A. Laposata and L. G. Lange (1986) Presence of non-oxidative ethanol metabolism in human organs commonly damaged by ethanol abuse. Science 231, 497–499.

    Article  PubMed  CAS  Google Scholar 

  9. E. A. Laposata, D. E. Scherrer, C. Mazow, and L. G. Lange (1987) Metabolism of ethanol by human brain to fatty acid ethyl esters. J. BioL Chem. 262, 4653–4657.

    PubMed  CAS  Google Scholar 

  10. E. A. Laposata, D. E. Scherrer, and L. G. Lange (1989) Fatty acid ethyl esters in adipose tissue. Arch. Pathol. Lab. Med. 113, 762–766.

    PubMed  CAS  Google Scholar 

  11. D. J. S. Riley, E. M. Kyger, C. A. Spilburg, and L. G. Lange (1990) Pancreatic cholesterol esterases. Purification and characterization of human pancreatic fatty acid ethyl ester synthase. Biochemistry 29, 3848–3852.

    Article  PubMed  CAS  Google Scholar 

  12. L. G. Lange, S. R. Bergman, and B. E. Sobel (1981) Identification of fatty acid ethyl esters as products of rabbit myocardial ethanol metabolism. J. BioL Chem. 256,12,968–12,973.

    Google Scholar 

  13. L. G. Lange (1982) Nonoxidative ethanol metabolism. Formation of fatty acid ethyl esters by cholesterol esterase. Proc. Natl. Acad ScL USA 79, 3954–3957.

    Article  CAS  Google Scholar 

  14. L. G. Lange and B. E. Sobel (1983) Mitochondrial dysfunction induced by fatty acid ethyl esters, myocardial metabolites of ethanol. J. Clin. Invest. 72, 724–731.

    Article  PubMed  CAS  Google Scholar 

  15. D. C. Mair, M. E. Donnell, and E. A. Laposata (1990) Fatty acid ethyl esters, a family of ethanol metabolites, mediate changes in protein secretion in HEP G2 cells. Clin. Res. 38, 264A (abstract).

    Google Scholar 

  16. S. Mogelson and L. G. Lange (1984) Nonoxidative ethanol metabolism in rabbit myocardium purification to homogeneity of fatty acid ethyl ester synthase. Biochemistry 23, 4075–4081.

    Article  PubMed  CAS  Google Scholar 

  17. P. M. Kinnunen and L. G. Lange (1984) Identification and quantification of fatty acid ethyl esters in biological specimens. Anal. Biochem. 140, 567–576.

    CAS  Google Scholar 

  18. P S. Bora, C. A. Spilburg, and L. G. Lange (1989) Identification of a satellite fatty acid ethyl ester synthase from human myocardium as a glutathione Stransferase. J. Clin. Invest. 84,1942–1946.

    Article  PubMed  CAS  Google Scholar 

  19. S. Mogelson, S. J. Pieper, and L. G. Lange (1984) Thermodynamic bases for fatty acid ethyl ester synthase catalyzed esterification of free fatty acid with ethanol and accumulation of fatty acid ethyl esters. Biochemistry 23, 4082–4087.

    Article  PubMed  CAS  Google Scholar 

  20. J. B. Hoek, A. P. Thomas, R. Rubin, and E. Rubin (1987) Ethanol-induced mobilization of calcium by activation of phosphoinositide-specific phospholipase C in intact hepatocytes. J. Biol. Chem. 262,682–691.

    PubMed  CAS  Google Scholar 

  21. P. S. Bora, C. A. Spilburg, and L. G. Lange (1989) Purificaton to homogeneity and characterization of major fatty acid ethyl ester synthase from human myocardium. FEBS Leu. 258,236–239.

    Article  CAS  Google Scholar 

  22. P S. Bora, C. A. Spilburg, and L. G. Lange (1989) Metabolism of ethanol and carcinogens by glutathione transferases. Proc. Natl. Acad. Sci. USA 86,4470–4473.

    Article  PubMed  CAS  Google Scholar 

  23. R S. Bora, C. A. Spilburg, and L. G. Lange (1989) Co-metabolism of ethanol and carcinogens by GSH transferases. Clin. Res. 37,247A (abstract).

    Google Scholar 

  24. P S. Bora, C. A. Spilburg, and L. G. Lange (1989) Ethanol and carcinogen metabolism by glutathione S-transferases. Clin. Res. 37, 897A (abstract).

    Google Scholar 

  25. R S. Bora and L. G. Lange (1991) Homogeneous Synthase I from human myocardium is a glutathione S-transferase. Ann. NY Acad. Sci. (in press).

    Google Scholar 

  26. Y. Suguoka, T. Kano, A. Okuda, M. Sakai, T. Kitagawa, and M. Muramatsu (1985) Cloning and the nucleotide sequence of rat glutathione S-transferase P cDNA. Nucleic Acids Res. 13,6049–6057.

    Article  PubMed  CAS  Google Scholar 

  27. A. M. Caccuri, C. Dillio, D. Campagnone, D. Barra, and G. Frederici (1989) Acidic glutathione transferase from human heart characterization and N-terminal sequence determination. Biochem. Med. Metab. Biol. 40,123–132.

    Article  Google Scholar 

  28. W. R. Habig, M. J. Rabst, and W. B. Jakoby (1974) Glutathione S-transferase: The first enzymatic step in metcapturic acid formation. J. Biol. Chem. 249, 7130–7139.

    PubMed  CAS  Google Scholar 

  29. G. Wistow and J. Piatigoslay (1987) Recruitment of enzymes as lens structural proteins. Science 236,1554–1556.

    Article  PubMed  CAS  Google Scholar 

  30. S. Tomarev and R. D. Zinovieva (1988) Squid major lens polypeptides are homologous to glutathione S-transferases subunits. Nature (Lond.) 336,86–88.

    Article  CAS  Google Scholar 

  31. R. M. David and D. E. Nerland (1983) Induction of mouse liver glutathione S-transferase by ethanol. Biochem. Pharmacol. 32,2809–2811.

    CAS  Google Scholar 

  32. C. B. Pickett, C. A. Tetakowsky-Hopkins, C. F. G. Ding, and V. D. M. Ding (1987) Sequence analysis and regulation of rat liver glutathione S-transferase mRNAs. Xenobiotica 17,317–323.

    Article  PubMed  CAS  Google Scholar 

  33. C. R. Cloninger, M. Bohman, and S. Sigvardsson (1981) Inheritance of alcohol abuse. Arch. Gen. Psychiatry 38,861–868.

    CAS  Google Scholar 

  34. D. W. Goodwin (1987) Genetic influence in alcoholism. Adv. Intern. Med. 32,283–297.

    CAS  Google Scholar 

  35. M. Wright, K. J. Bieser, P. M. Kinnunen, and L. G. Lange (1987) Nonoxidative ethanol metabolism in human leukocytes: Detection of fatty acid ethyl ester synthase activity. Biochem. Biophys. Res. Commun. 142,979–985.

    CAS  Google Scholar 

  36. S. B. Gilligan, L. G. Lange, T. Reich, and C. R. Cloninger (1987) Nonoxidative ethanol metabolism in alcoholic pedigrees. Am. J. Hum. Genet. 41, A255 (abstr).

    Google Scholar 

  37. C. S. Lieber, H. K. Seitz, and H. J. Gaoro (1987) Alcohol-related diseases and carcinogenesis. Cancer Res. 39, 2863–2867.

    Google Scholar 

  38. J. E. Engstrom (1977) Colorectal cancer and beer drinking. Br. J. Cancer Res. 35,679–684.

    Google Scholar 

Download references

Authors
  1. Puran S. Bora
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Louis G. Lange
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. University of Arizona, Tucson, Arizona, USA

    Ronald R. Watson

Rights and permissions

Reprints and permissions

Copyright information

© 1991 Springer Science+Business Media New York

About this chapter

Cite this chapter

Bora, P.S., Lange, L.G. (1991). Fatty Acid Ethyl Esters, Alcohol, and Liver Changes. In: Watson, R.R. (eds) Liver Pathology and Alcohol. Drug and Alcohol Abuse Reviews, vol 2. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0421-3_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4612-0421-3_9

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6755-3

  • Online ISBN: 978-1-4612-0421-3

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation