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The HIV tat Gene Induces Epidermal Hyperplasia in vivo and Transforms Keratinocytes in vitro

  • Chapter
Neoplastic Transformation in Human Cell Culture

Part of the book series: Experimental Biology and Medicine ((EBAM,volume 25))

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Abstract

Many Dermatologic disorders are associated with the acquired immune deficiency syndrome (AIDS). Kaposi’s sarcoma, psoriasis, seborrheic dermatitis, squamous cell carcinoma, basal cell carcinoma, and melanoma are all increased in frequency in the AIDS population (1,2). Multiple pathologic processes are likely to be at work in inducing the complex manifestations of AIDS, including the direct effects of infection with the human immunodeficiency virus (HIV), the indirect effects of profound immune dysfunction, and the involvement of multiple other infectious agents (3,4).

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Author information

Authors and Affiliations

  1. Laboratory of Virology, Jerome H. Holland Laboratory, American Red Cross, Rockville, MD, USA

    Jonathan A. Rhim, Jonathan Vogel, Chang-Min Kim & Gilbert Jay

  2. Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD, USA

    Johng S. Rhim

Authors
  1. Jonathan A. Rhim
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  2. Jonathan Vogel
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  3. Chang-Min Kim
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  4. Gilbert Jay
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  5. Johng S. Rhim
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Editor information

Editors and Affiliations

  1. Laboratory of Cellular and Molecular Biology, National Cancer Institute, Bethesda, MD, USA

    Johng S. Rhim

  2. Department of Radiation Medicine, Georgetown University Medical Center, Washington DC, USA

    Anatoly Dritschilo

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© 1991 Springer Science+Business Media New York

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Rhim, J.A., Vogel, J., Kim, CM., Jay, G., Rhim, J.S. (1991). The HIV tat Gene Induces Epidermal Hyperplasia in vivo and Transforms Keratinocytes in vitro . In: Rhim, J.S., Dritschilo, A. (eds) Neoplastic Transformation in Human Cell Culture. Experimental Biology and Medicine, vol 25. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0411-4_15

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  • DOI: https://doi.org/10.1007/978-1-4612-0411-4_15

  • Publisher Name: Humana Press, Totowa, NJ

  • Print ISBN: 978-1-4612-6750-8

  • Online ISBN: 978-1-4612-0411-4

  • eBook Packages: Springer Book Archive

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