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Molecular Basis of Neurologic Disorders Induced by a Mutant, ts1, of Moloney Murine Leukemia Virus

  • Chapter
Molecular Neurovirology

Abstract

The consequences of retrovirus infection range widely. In some instances, infection induces cellular proliferation that can result in neoplasia, whereas in other cases, infection results in cell killing leading to degenerative diseases. The Moloney murine leukemia (MoMuLV) system is a good example of this diverse effect of retroviruses on the infected host. Although MoMuLV primarily causes T-cell lymphoma (1–3), several temperature-sensitive (ts) mutants of MoMuLV have been shown to cause degenerative disorders of the nervous system (4–6). One of these ts mutants, designated ts1 , has been studied most intensively. ts1 was the first neurovirulent retrovirus to be isolated in vitro from a nonneurovirulent MuLV (7). Prior to the isolation of ts1 , naturally occurring neurovirulent MuLVs had been isolated from wild mice (8). A discussion of a naturally occurring neurovirulent MuLV is given in the chapter by Jolicoeur, Gravel, and Kay in this book. Neurovirulent or neurotropic MuLVs have also been generated from nonneurovirulent strains of MuLV by passaging MuLVs in cells or animals or by manipulating the viruses in vitro (4, 9–13).

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Authors
  1. Paul K. Y. Wong
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  2. P. H. Yuen
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Editors and Affiliations

  1. University of Chicago Medical Center, Chicago, Illinois, USA

    Raymond P. Roos

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Wong, P.K.Y., Yuen, P.H. (1992). Molecular Basis of Neurologic Disorders Induced by a Mutant, ts1, of Moloney Murine Leukemia Virus. In: Roos, R.P. (eds) Molecular Neurovirology. Humana Press, Totowa, NJ. https://doi.org/10.1007/978-1-4612-0407-7_3

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  • DOI: https://doi.org/10.1007/978-1-4612-0407-7_3

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