EBNA-2 Transactivation of CD23

  • F. Wang
  • H. Kikutani
  • S. Tsang
  • T. Kishimoto
  • E. Kieff
Part of the Experimental Biology and Medicine book series (EBAM, volume 24)


Epstein-Barr virus nuclear protein-2 (EBNA-2) is an essential gene for Epstein-Barr virus (EBV) induced B lymphocyte growth transformation (1,2). EBNA-2 induces both viral and cellular gene expression including the EBV latent membrane protein (LMP1), CD21, CD23, and c-fgr (3,4,5,6,7). CD23 is a B lymphocyte activation marker which is closely associated with EBV induced B lymphocyte growth transformation (8,9). Recent studies of CD23 expression in BJAB cells after EBNA-2 and LMP1 transfection revealed that these proteins acted synergistically to induce high level CD23 expression (6). LMP1 induced specifically the type b CD23 mRNA, whereas EBNA-2 induced both type a and type b CD23 mRNA transcribed from different promoters. These studies suggested that EBNA-2 transactivated an enhancer of general CD23 transcription.


CD23 mRNA Chloramphenicol Acetyl Transferase CD23 Promoter BJAB Cell Fold Average Increase 
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Copyright information

© Springer Science+Business Media New York 1991

Authors and Affiliations

  • F. Wang
    • 1
  • H. Kikutani
    • 2
  • S. Tsang
    • 1
  • T. Kishimoto
    • 2
  • E. Kieff
    • 1
  1. 1.Departments of Medicine and Microbiology and Molecular GeneticsHarvard Medical SchoolBostonUSA
  2. 2.Division of Immunology, Institute for Molecular and Cellular BiologyOsaka UniversityOsakaJapan

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